DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and FVE

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_565456.2	Gene:	FVE / 816471	AraportID:	AT2G19520	Length:	507	Species:	Arabidopsis thaliana

Alignment Length:	349	Identity:	86/349 - (24%)
Similarity:	129/349 - (36%)	Gaps:	89/349 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 AIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGN-EWFATGAGDRVIKIWDL 201
            |.|.|:....::|.| |..|     |...:|  |.|.|..|...|.| :..||......:.|||:
plant   138 AAAEHISQFNEEARS-PFVK-----KYKTII--HPGEVNRIRELPQNSKIVATHTDSPDVLIWDV 194

  Fly   202 ------------ASGKLKLSLTGHVSTVR-GVAVSTKHPYLFSCGEDRQVKCWDLE--------- 244
                        |:.:..|.||||..... .:|:....|::.|.|:|:.|..|.::
plant   195 ETQPNRHAVLGAANSRPDLILTGHQDNAEFALAMCPTEPFVLSGGKDKSVVLWSIQDHITTIGTD 259

  Fly   245 ---YNKVIRH------------------YHGHLSAVYSLALHPT-IDVLATSGRDSTARIWDMRT 287
               ...:|:.                  ||||...|..:|..|| .....:.|.||...:||.||
plant   260 SKSSGSIIKQTGEGTDKNESPTVGPRGVYHGHEDTVEDVAFSPTSAQEFCSVGDDSCLILWDART 324

  Fly   288 KANVHTLTGHTNTVASVVAQATNPQ----IITGSHDSTVRLWD---LAA---GKSVCTLTNHKKS 342
            ..|..|.....:. |.:.....||.    |:|||.|:||||:|   |.|   |..:.....||.:
plant   325 GTNPVTKVEKAHD-ADLHCVDWNPHDDNLILTGSADNTVRLFDRRKLTANGVGSPIYKFEGHKAA 388

  Fly   343 VRSIVLHP-SLYMFASASPDNIKQ-W-------------RCPEGKFVQNISGHTSIVN------- 385
            |..:...| ...:|.|::.|.:.. |             :.|.|.|.|:......:|:
plant   389 VLCVQWSPDKSSVFGSSAEDGLLNIWDYDRVSKKSDRAAKSPAGLFFQHAGHRDKVVDFHWNASD 453

  Fly   386 --CMAANSEGVLVSGGDNGTMFFW 407
              .:.:.|:....:|| .||:..|
plant   454 PWTIVSVSDDCETTGG-GGTLQIW 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	79/326 (24%)
		WD40	164..458	CDD:238121	78/323 (24%)
		WD40 repeat	177..212	CDD:293791	11/47 (23%)
		WD40 repeat	218..254	CDD:293791	9/66 (14%)
		WD40 repeat	259..295	CDD:293791	13/36 (36%)
		WD40 repeat	302..337	CDD:293791	16/44 (36%)
		WD40 repeat	343..378	CDD:293791	10/49 (20%)
		WD40 repeat	386..426	CDD:293791	6/22 (27%)
		WD40 repeat	433..457	CDD:293791
FVE	NP_565456.2	CAF1C_H4-bd	66..134	CDD:403473
		WD40	163..477	CDD:421866	77/316 (24%)
		WD40 repeat	168..217	CDD:293791	11/48 (23%)
		WD40 repeat	222..289	CDD:293791	8/66 (12%)
		WD40 repeat	296..333	CDD:293791	12/36 (33%)
		WD40 repeat	340..383	CDD:293791	15/42 (36%)
		WD40 repeat	389..438	CDD:293791	10/48 (21%)
		WD40 repeat	444..476	CDD:293791	6/32 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910