DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Katnb1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_083081.2	Gene:	Katnb1 / 74187	MGIID:	1921437	Length:	658	Species:	Mus musculus

Alignment Length:	250	Identity:	70/250 - (28%)
Similarity:	118/250 - (47%)	Gaps:	3/250 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 WKLSRVISGHLGWVRCIAV-EPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTK 225
            |||..::: |...|..:.: :......|||..|..:.:|.:......:|||||.|.|..|.::|.
Mouse    11 WKLQEIVA-HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTP 74

  Fly   226 HPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKAN 290
            ...:.:..:...::.||||..|::|...||.:.:.||..||..:.:|:..:|:..::||:|.|..
Mouse    75 EELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC 139

  Fly   291 VHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMF 355
            |....||:..|..:........:.:.:.|.||:||||.|||.:.....|...|..:..||:.|:.
Mouse   140 VFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLL 204

  Fly   356 ASASPD-NIKQWRCPEGKFVQNISGHTSIVNCMAANSEGVLVSGGDNGTMFFWDW 409
            ||.|.| .|:.|...:.:.|..|.|....|..:..|.:|..:..|...::..:.|
Mouse   205 ASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGW 259

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	69/249 (28%)
		WD40	164..458	CDD:238121	67/247 (27%)
		WD40 repeat	177..212	CDD:293791	7/35 (20%)
		WD40 repeat	218..254	CDD:293791	8/35 (23%)
		WD40 repeat	259..295	CDD:293791	11/35 (31%)
		WD40 repeat	302..337	CDD:293791	10/34 (29%)
		WD40 repeat	343..378	CDD:293791	11/35 (31%)
		WD40 repeat	386..426	CDD:293791	3/23 (13%)
		WD40 repeat	433..457	CDD:293791
Katnb1	NP_083081.2	Interaction with centrosomes. /evidence=ECO:0000250	1..300		69/249 (28%)
		Interaction with dynein	1..284		69/249 (28%)
		WD40	7..257	CDD:238121	69/246 (28%)
		WD40 repeat	67..103	CDD:293791	8/35 (23%)
		WD40 repeat	108..144	CDD:293791	11/35 (31%)
		WD40 repeat	151..186	CDD:293791	10/34 (29%)
		WD40 repeat	192..228	CDD:293791	11/35 (31%)
		WD40 repeat	234..261	CDD:293791	4/25 (16%)
		Interaction with PAFAH1B1. /evidence=ECO:0000269\|PubMed:16203747	285..437
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..419
		MARCKS	<367..465	CDD:366900
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	434..458
		Interaction with KATNA1 and NDEL1. /evidence=ECO:0000269\|PubMed:16203747	436..658
		Katanin_con80	500..651	CDD:372820
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910