DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and MLST8

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_005255532.2	Gene:	MLST8 / 64223	HGNCID:	24825	Length:	351	Species:	Homo sapiens

Alignment Length:	331	Identity:	74/331 - (22%)
Similarity:	125/331 - (37%)	Gaps:	43/331 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 HAPWK---LSRVISGHLGWVRCIAVEPGNEW-----FATGAGDRVIKIWDLASGKLKLSLTGHVS 215
            ||||.   .||..:||     .:...||...     .||...|..::.|...||....::....|
Human     3 HAPWSPGASSRARAGH-----TMNTSPGTVGSDPVILATAGYDHTVRFWQAHSGICTRTVQHQDS 62

  Fly   216 TVRGVAVSTKHPYLFSCGED-----RQVKCWDLEYN--KVIRHYHGHLSAVYSLALHPTIDVLAT 273
            .|..:.|:.....:.:..:.     :.::.:||..|  ..|..|.|....:.|:..|.....:.|
Human    63 QVNALEVTPDRSMIAAAVQPVSLGYQHIRMYDLNSNNPNPIISYDGVNKNIASVGFHEDGRWMYT 127

  Fly   274 SGRDSTARIWDMRTK----ANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVC 334
            .|.|.||||||:|::    ..:..:....|.|.....||   ::|.|.....:.:|||....:..
Human   128 GGEDCTARIWDLRSRNLQCQRIFQVNAPINCVCLHPNQA---ELIVGDQSGAIHIWDLKTDHNEQ 189

  Fly   335 TLTNHKKSVRSIVLHP-SLYMFASASPDNIKQWRCPEG---KFVQ-----NISGHTS-IVNCMAA 389
            .:...:.|:.|..:.| :.||.|..|..|...|....|   :..|     .|..||. .:.|..:
Human   190 LIPEPEVSITSAHIDPDASYMAAVNSTGNCYVWNLTGGIGDEVTQLIPKTKIPAHTRYALQCRFS 254

  Fly   390 NSEGVLVSGGDNGTMFFWDWRTGYNFQRF-QAPVQPGS--MDSEAGIFAMCFDQSGSRLITAEAD 451
            ....:|.:...:.|...  |||. ||... :..::.|:  ..|...::...|......::||.:|
Human   255 PDSTLLATCSADQTCKI--WRTS-NFSLMTELSIKSGNPGESSRGWMWGCAFSGDSQYIVTASSD 316

  Fly   452 KTIKVY 457
            ...:::
Human   317 NLARLW 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	72/329 (22%)
		WD40	164..458	CDD:238121	70/323 (22%)
		WD40 repeat	177..212	CDD:293791	8/39 (21%)
		WD40 repeat	218..254	CDD:293791	6/42 (14%)
		WD40 repeat	259..295	CDD:293791	12/39 (31%)
		WD40 repeat	302..337	CDD:293791	7/34 (21%)
		WD40 repeat	343..378	CDD:293791	10/43 (23%)
		WD40 repeat	386..426	CDD:293791	8/40 (20%)
		WD40 repeat	433..457	CDD:293791	4/23 (17%)
MLST8	XP_005255532.2	WD40	<17..330	CDD:225201	68/317 (21%)
		WD40	33..322	CDD:238121	64/294 (22%)
		WD40 repeat	66..108	CDD:293791	6/41 (15%)
		WD40 repeat	114..152	CDD:293791	12/37 (32%)
		WD40 repeat	156..192	CDD:293791	9/38 (24%)
		WD40 repeat	199..242	CDD:293791	10/42 (24%)
		WD40 repeat	249..283	CDD:293791	8/36 (22%)
		WD40 repeat	298..324	CDD:293791	4/25 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010