DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and snrnp40

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001025544.1	Gene:	snrnp40 / 594941	XenbaseID:	XB-GENE-957415	Length:	337	Species:	Xenopus tropicalis

Alignment Length:	339	Identity:	87/339 - (25%)
Similarity:	151/339 - (44%)	Gaps:	44/339 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 LQLIPKKAPSIPKPK-------------WHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDR 194
            ::|:|.:|   .||:             ..||..|   :|||.|.|.|....|.....::...||
Frog    10 MELVPVQA---KKPRNELVVSGPPRSSSLQAPIML---LSGHEGEVYCCKFHPNGVTLSSAGFDR 68

  Fly   195 VIKIWDL-ASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSA 258
            :|.:|:: .......:|.||...|..:..:|....|||...|:.|..||.|..:.::...||.|.
Frog    69 LILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSLLFSASTDKTVAIWDCETGERVKRLKGHTSF 133

  Fly   259 VYSLALHPT---IDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDS 320
            |.|  .:|.   ..::.|...|.|.::||.|.||.|.|.. :|..|.||....|:.|||:|..|:
Frog   134 VNS--CYPARRGPQLICTGSDDGTVKLWDFRKKAAVQTFQ-NTYQVLSVTFNDTSDQIISGGIDN 195

  Fly   321 TVRLWDLAAGKSVCTLTNHKKSVRSIVL-HPSLYMFASASPDNIKQWR----CPEGKFVQNISGH 380
            .:::|||...|.:.|:..|..||..:.| ....|:.::|..:.::.|.    .|:.:.|:...|:
Frog   196 DIKVWDLRQNKLMYTMRGHGDSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGN 260

  Fly   381 T-----SIVNCMAANSEGVLVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQ 440
            .     :::.| :.:::|..::.| :...|.:.|.|......::.|...||::..|      |..
Frog   261 VHNFEKNLLRC-SWSADGSKIAAG-SADRFVYVWDTTSRRILYKLPGHAGSVNEVA------FHP 317

  Fly   441 SGSRLITAEADKTI 454
            ....:::|.:||.:
Frog   318 EEPIILSAASDKRL 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	81/308 (26%)
		WD40	164..458	CDD:238121	80/305 (26%)
		WD40 repeat	177..212	CDD:293791	7/35 (20%)
		WD40 repeat	218..254	CDD:293791	9/35 (26%)
		WD40 repeat	259..295	CDD:293791	13/38 (34%)
		WD40 repeat	302..337	CDD:293791	13/34 (38%)
		WD40 repeat	343..378	CDD:293791	7/39 (18%)
		WD40 repeat	386..426	CDD:293791	7/39 (18%)
		WD40 repeat	433..457	CDD:293791	4/22 (18%)
snrnp40	NP_001025544.1	WD40	42..331	CDD:238121	79/299 (26%)
		WD40 repeat	50..87	CDD:293791	7/36 (19%)
		WD40 repeat	92..128	CDD:293791	10/35 (29%)
		WD40 repeat	135..170	CDD:293791	11/36 (31%)
		WD40 repeat	176..212	CDD:293791	14/35 (40%)
		WD40 repeat	218..258	CDD:293791	7/39 (18%)
		WD40 repeat	268..292	CDD:293791	4/25 (16%)
		WD40 repeat	310..332	CDD:293791	5/28 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910