DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and fbxw7

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_009289569.3	Gene:	fbxw7 / 564991	ZFINID:	ZDB-GENE-090313-79	Length:	835	Species:	Danio rerio

Alignment Length:	333	Identity:	92/333 - (27%)
Similarity:	147/333 - (44%)	Gaps:	43/333 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 KAPSIPKPKW-HAPWKLSRVISGH---LGWVRCIAVEP------------------GNEWFATGA 191
            |...:.||.: |:||| |..|..|   ..|.|.....|                  ||. ..:|:
Zfish   464 KRRKVIKPGFTHSPWK-SAYIRQHRIDTNWRRGDLKSPKVVLKGHDDHVITCLQFCGNR-IVSGS 526

  Fly   192 GDRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGE-DRQVKCWDLEYNKVIRHYHGH 255
            .|..:|:|...:||...:|.||..   ||..|.....:...|. ||.:|.|:.|..:.|...:||
Zfish   527 DDNTLKVWSAVTGKCLRTLVGHTG---GVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGH 588

  Fly   256 LSAVYSLALHPTIDVLATSG-RDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHD 319
            .|.|..:.||   :....|| ||:|.|:||:.|...:|.|.||...|..|  |....::::|::|
Zfish   589 TSTVRCMHLH---EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCV--QYDGRRVVSGAYD 648

  Fly   320 STVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIV 384
            ..|::||......:.||..|...|.|:.. ..:::.:.:...:|:.|....|..:..::||.|:.
Zfish   649 FMVKVWDPETETCLHTLQGHTNRVYSLQF-DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 712

  Fly   385 NCMAANSEGVLVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAE 449
            :.|.. .:.:||||..:.|:..||.:||...|..|.|.:..|.       ..|...:.:.:||:.
Zfish   713 SGMEL-KDNILVSGNADSTVKIWDIKTGQCLQTLQGPHKHQSA-------VTCLQFNKNFVITSS 769

  Fly   450 ADKTIKVY 457
            .|.|:|::
Zfish   770 DDGTVKLW 777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	88/320 (28%)
		WD40	164..458	CDD:238121	85/317 (27%)
		WD40 repeat	177..212	CDD:293791	10/52 (19%)
		WD40 repeat	218..254	CDD:293791	10/36 (28%)
		WD40 repeat	259..295	CDD:293791	13/36 (36%)
		WD40 repeat	302..337	CDD:293791	8/34 (24%)
		WD40 repeat	343..378	CDD:293791	5/34 (15%)
		WD40 repeat	386..426	CDD:293791	13/39 (33%)
		WD40 repeat	433..457	CDD:293791	6/23 (26%)
fbxw7	XP_009289569.3	F-box-like	408..452	CDD:315592
		WD40	503..778	CDD:238121	79/293 (27%)
		WD40 repeat	512..547	CDD:293791	9/35 (26%)
		WD40 repeat	553..587	CDD:293791	8/33 (24%)
		WD40 repeat	592..626	CDD:293791	13/36 (36%)
		WD40 repeat	633..666	CDD:293791	8/34 (24%)
		WD40 repeat	672..706	CDD:293791	5/34 (15%)
		WD40 repeat	714..746	CDD:293791	11/32 (34%)
		WD40 repeat	755..777	CDD:293791	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910