DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and ciao1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_012814508.1	Gene:	ciao1 / 549641	XenbaseID:	XB-GENE-1010751	Length:	334	Species:	Xenopus tropicalis

Alignment Length:	260	Identity:	69/260 - (26%)
Similarity:	113/260 - (43%)	Gaps:	66/260 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 LFSCGEDRQVKCWDLE-YNKVIRHY--HGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKAN 290
            |.|||.||.::.|..: .|.|.:..  .||...|..::..|..:.||::..|:|..|| |:.|..
Frog    31 LASCGGDRTIRIWGKDGDNWVCKSVLGEGHQRTVRKVSWSPCGNYLASASFDATTCIW-MKKKEE 94

  Fly   291 ---VHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKS---VCTLTNHKKSVRSIVLH 349
               :.||.||.|.|.||....:...:.|.|.|.:|.:|::...:.   |..|.:|.:.|:.:|.|
Frog    95 FECITTLEGHENEVKSVAWAPSGSLLATCSRDKSVWVWEVDEEEEYECVSVLNSHTQDVKHVVWH 159

  Fly   350 PSLYMFASAS-PDNIKQWRCPEGKFV--QNISGHTSIVNCMAANSEGVLVSGGDNGTMFFWDWRT 411
            |:..:.|||| .|::|.:|..|..:|  ..:.||||.|                        |
Frog   160 PNQELLASASYDDSVKLYREEEDDWVCCATLEGHTSTV------------------------W-- 198

  Fly   412 GYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAEADKTIKVYKE---DDEASEESHPINWR 473
                                   ::.|||:|.:|.|...|||::::::   .::...:|.| ||:
Frog   199 -----------------------SLAFDQTGEQLATCSDDKTVRIWRQLGTGEQVGSKSDP-NWK 239

Fly 474 473
Frog 240 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	65/240 (27%)
		WD40	164..458	CDD:238121	65/240 (27%)
		WD40 repeat	177..212	CDD:293791
		WD40 repeat	218..254	CDD:293791	9/27 (33%)
		WD40 repeat	259..295	CDD:293791	11/38 (29%)
		WD40 repeat	302..337	CDD:293791	8/37 (22%)
		WD40 repeat	343..378	CDD:293791	13/37 (35%)
		WD40 repeat	386..426	CDD:293791	1/39 (3%)
		WD40 repeat	433..457	CDD:293791	9/23 (39%)
ciao1	XP_012814508.1	WD40	17..329	CDD:238121	69/260 (27%)
		WD40 repeat	19..59	CDD:293791	9/27 (33%)
		WD40	22..>332	CDD:225201	69/260 (27%)
		WD40 repeat	65..103	CDD:293791	11/38 (29%)
		WD40 repeat	108..147	CDD:293791	9/38 (24%)
		WD40 repeat	154..191	CDD:293791	12/36 (33%)
		WD40 repeat	197..245	CDD:293791	15/93 (16%)
		WD40 repeat	252..292	CDD:293791
		WD40 repeat	303..328	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910