DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and rack1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001004946.1	Gene:	rack1 / 448353	XenbaseID:	XB-GENE-5927078	Length:	317	Species:	Xenopus tropicalis

Alignment Length:	329	Identity:	84/329 - (25%)
Similarity:	126/329 - (38%)	Gaps:	88/329 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LSRVISGHLGWVRCIAVEPG-NEWFATGAGDRVIKIWDLAS-----GKLKLSLTGHVSTVRGVAV 222
            |...:.||.|||..||..|. .:...:.:.|:.:.:|.|..     |..:.:|.||...|..|.:
Frog     7 LRGTLKGHNGWVTQIATTPQFPDMILSSSRDKTVIMWKLTRDETNYGVPQRALRGHSHFVSDVVI 71

  Fly   223 STKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGR-DSTARIWDMR 286
            |:          |.|                                 .|.||. |.|.|:||:.
Frog    72 SS----------DGQ---------------------------------FALSGSWDGTLRLWDLT 93

  Fly   287 TKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLT----NHKKSVRSIV 347
            |........|||..|.||...|.|.||::||.|.|::||:..   .||..|    :|.:.|..:.
Frog    94 TGTTTRRFVGHTKDVLSVAFSADNRQIVSGSRDKTIKLWNTL---GVCKYTVQEESHTEWVSCVR 155

  Fly   348 LHPSLYMFASASP--------DNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGVL-VSGGDNGT 403
            ..|:     |::|        ..:|.|.....|...|..||:..:|.:..:.:|.| .|||.:|.
Frog   156 FSPN-----SSNPIIVSCGWDKMVKVWNLANCKLKTNHIGHSGYLNTVTVSPDGSLCASGGKDGQ 215

  Fly   404 MFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRL-ITAEADKTIKVYKED-----DE 462
            ...||...|.:..         ::||...|.|:||  |.:|. :.|....:||::..:     ||
Frog   216 AMLWDLNEGKHLY---------TLDSGDVINALCF--SPNRYWLCAATGPSIKIWDLEGKIIVDE 269

  Fly   463 ASEE 466
            ..:|
Frog   270 LKQE 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	81/314 (26%)
		WD40	164..458	CDD:238121	81/314 (26%)
		WD40 repeat	177..212	CDD:293791	8/40 (20%)
		WD40 repeat	218..254	CDD:293791	4/35 (11%)
		WD40 repeat	259..295	CDD:293791	9/36 (25%)
		WD40 repeat	302..337	CDD:293791	14/34 (41%)
		WD40 repeat	343..378	CDD:293791	8/42 (19%)
		WD40 repeat	386..426	CDD:293791	9/40 (23%)
		WD40 repeat	433..457	CDD:293791	9/24 (38%)
rack1	NP_001004946.1	WD40	7..311	CDD:238121	84/329 (26%)
		WD40 repeat	18..61	CDD:293791	9/42 (21%)
		WD40 repeat	67..103	CDD:293791	13/78 (17%)
		WD40 repeat	108..144	CDD:293791	16/38 (42%)
		WD40 repeat	152..189	CDD:293791	7/41 (17%)
		WD40 repeat	195..231	CDD:293791	10/44 (23%)
		WD40 repeat	236..279	CDD:293791	12/40 (30%)
		WD40 repeat	286..310	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910