DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and gnb3b

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_998367.1	Gene:	gnb3b / 406483	ZFINID:	ZDB-GENE-040426-2280	Length:	338	Species:	Danio rerio

Alignment Length:	392	Identity:	87/392 - (22%)
Similarity:	141/392 - (35%)	Gaps:	76/392 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 GNLPEIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQTPGDKTLA-----------ITD 84
            |.:.::.:..|.|:..|:|........|..|.......|...|....|||.           .||
Zfish     2 GEMEQMKKEAEGLKTQIEAARKAAHDTDMAAAAAGVAPAPRVQLKTRKTLKGHLAKIYAMHWCTD 66

  Fly    85 GSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQLIPKK 149
            .....:||..|.|:.::|.:.......||    .:|.|.......:.::.|:|.:.:...:...|
Zfish    67 NRLMVSASQDGKLLIWDAHSGNKVNAVPL----KSSWVMTCSYAPSGNLVASGGLDNMCTVYNLK 127

  Fly   150 APSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHV 214
            .|.|         |..:.:..|.|::.|.......| ..|.:||....:|||.:||.|.....|:
Zfish   128 TPVI---------KTVKELDAHTGYLSCCRFISDTE-IVTSSGDTTCALWDLETGKQKTVFLNHI 182

  Fly   215 STVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDST 279
            .               .|      .|                     |:|.|..::..:...||.
Zfish   183 G---------------DC------MC---------------------LSLSPDNNMFISGACDSL 205

  Fly   280 ARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNH--KKS 342
            |::||:|......|..|||:.:.::....:....||||.|.|.:::|:.|.:.|....:.  ...
Zfish   206 AKLWDIRDGQCKQTFQGHTSDINAISFLPSATAFITGSDDCTCKMYDIRADQEVICYQDSALNSG 270

  Fly   343 VRSIVLHPS-LYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGVLVSGGDNGTMFF 406
            |.|:.|..| ..:||.....|...|...:|:.|..:|||.:.|:|.....:|:.|..|.
Zfish   271 VTSVALSVSGRLIFAGYDDFNCNIWDSLKGEKVGVLSGHDNRVSCTGVPGDGMCVCTGS------ 329

  Fly   407 WD 408
            ||
Zfish   330 WD 331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	59/251 (24%)
		WD40	164..458	CDD:238121	58/248 (23%)
		WD40 repeat	177..212	CDD:293791	11/34 (32%)
		WD40 repeat	218..254	CDD:293791	2/35 (6%)
		WD40 repeat	259..295	CDD:293791	10/35 (29%)
		WD40 repeat	302..337	CDD:293791	9/34 (26%)
		WD40 repeat	343..378	CDD:293791	10/35 (29%)
		WD40 repeat	386..426	CDD:293791	6/23 (26%)
		WD40 repeat	433..457	CDD:293791
gnb3b	NP_998367.1	WD40	<46..338	CDD:225201	78/348 (22%)
		WD40	48..338	CDD:238121	78/346 (23%)
		WD40 repeat	58..95	CDD:293791	7/36 (19%)
		WD40 repeat	101..139	CDD:293791	6/46 (13%)
		WD40 repeat	144..179	CDD:293791	11/35 (31%)
		WD40 repeat	186..221	CDD:293791	11/55 (20%)
		WD40 repeat	227..263	CDD:293791	9/35 (26%)
		WD40 repeat	271..307	CDD:293791	10/35 (29%)
		WD40 repeat	313..337	CDD:293791	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910