DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and wdr5

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_998264.1	Gene:	wdr5 / 406372	ZFINID:	ZDB-GENE-040426-2082	Length:	334	Species:	Danio rerio

Alignment Length:	333	Identity:	92/333 - (27%)
Similarity:	159/333 - (47%)	Gaps:	24/333 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIW 199
            |:.|.||.    .|.||..|.      :.|...::||...|..:...|..||.|:.:.|::||||
Zfish    18 ASAASASQ----SKSAPVKPN------YTLKFTLAGHTKAVSSVKFSPSGEWLASSSADKLIKIW 72

  Fly   200 DLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLAL 264
            ....||.:.:::||...:..||.|:....|.|..:|:.:|.||:...|.::...||.:.|:....
Zfish    73 GAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF 137

  Fly   265 HPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAA 329
            :|..:::.:...|.:.||||::|...:.||..|::.|::|........|::.|:|...|:||.|:
Zfish   138 NPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202

  Fly   330 GKSVCTLTNHKKSVRSIV-LHPS-LYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSE 392
            |:.:.||.:......|.| ..|: .|:.|:...:.:|.|...:||.::..:||.:...|:.||..
Zfish   203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFS 267

  Fly   393 GV----LVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITA-EADK 452
            ..    :|||.::..::.|:.:|....|:.|.       .::..|...|..........| |.||
Zfish   268 VTGGKWIVSGSEDNMVYIWNLQTKEIVQKLQG-------HTDVVISTACHPTENIIASAALENDK 325

  Fly   453 TIKVYKED 460
            |||::|.|
Zfish   326 TIKLWKSD 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	82/303 (27%)
		WD40	164..458	CDD:238121	82/300 (27%)
		WD40 repeat	177..212	CDD:293791	11/34 (32%)
		WD40 repeat	218..254	CDD:293791	10/35 (29%)
		WD40 repeat	259..295	CDD:293791	9/35 (26%)
		WD40 repeat	302..337	CDD:293791	10/34 (29%)
		WD40 repeat	343..378	CDD:293791	9/36 (25%)
		WD40 repeat	386..426	CDD:293791	10/43 (23%)
		WD40 repeat	433..457	CDD:293791	9/24 (38%)
wdr5	NP_998264.1	WD40	37..331	CDD:238121	82/300 (27%)
		WD40 repeat	48..85	CDD:293791	12/36 (33%)
		WD40 repeat	91..127	CDD:293791	10/35 (29%)
		WD40 repeat	132..168	CDD:293791	9/35 (26%)
		WD40 repeat	175..210	CDD:293791	10/34 (29%)
		WD40 repeat	217..253	CDD:293791	9/35 (26%)
		WD40 repeat	261..298	CDD:293791	9/36 (25%)
		WD40 repeat	304..330	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920