DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and wdr21

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_956995.1	Gene:	wdr21 / 393674	ZFINID:	ZDB-GENE-040109-2	Length:	505	Species:	Danio rerio

Alignment Length:	250	Identity:	60/250 - (24%)
Similarity:	94/250 - (37%)	Gaps:	49/250 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 SLVRASL-ANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPG 183
            ||:.||| :|.|.|..  |.:.|.      |..:    .|...|.|:               ...
Zfish   252 SLLPASLFSNFNPDQP--GMLCSF------KIST----AWSCAWCLN---------------PQA 289

  Fly   184 NEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYN-- 246
            ::.|:||...||| :.|..:|:....|..  |.|.....:.:.|.||:.....::...||...
Zfish   290 DKTFSTGLSRRVI-VTDAVTGRRATYLAD--SDVLAQQFALRAPVLFNGCRSGEIFSIDLRQRDR 351

  Fly   247 --------KVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVAS 303
                    |..|.|..  ||:.|:.|....:.|..:......::||:|.|..|....||.|..|.
Zfish   352 GRMGFHGWKTSRFYQE--SAITSVQLLQDENYLLAADMLGKIKLWDIRVKRCVKQYEGHHNEYAY 414

  Fly   304 VVAQATNPQ--IITGSHDSTVRLWDLAAGKSVCTLTN-H---KKSVRSIVLHPSL 352
            :......|:  ::....|...|||.|...:.:.|:.: |   |.|:.::|..|.|
Zfish   415 LPIHINEPEGLLLAVGQDCYTRLWSLQDSRLLRTIPSPHPAGKDSIPNVVFSPQL 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	47/207 (23%)
		WD40	164..458	CDD:238121	46/204 (23%)
		WD40 repeat	177..212	CDD:293791	9/34 (26%)
		WD40 repeat	218..254	CDD:293791	8/45 (18%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	302..337	CDD:293791	8/36 (22%)
		WD40 repeat	343..378	CDD:293791	2/9 (22%)
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
wdr21	NP_956995.1	WD40	119..474	CDD:225201	59/249 (24%)
		WD40 repeat	278..315	CDD:293791	11/52 (21%)
		WD40 repeat	321..363	CDD:293791	6/41 (15%)
		WD40	<367..>467	CDD:295369	25/101 (25%)
		WD40 repeat	370..406	CDD:293791	8/35 (23%)
		WD40 repeat	414..450	CDD:293791	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910