DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Dcaf4

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_006240409.1	Gene:	Dcaf4 / 362762	RGDID:	1306241	Length:	519	Species:	Rattus norvegicus

Alignment Length:	452	Identity:	89/452 - (19%)
Similarity:	146/452 - (32%)	Gaps:	137/452 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMEDVQKHSVHTLIFR--SLKRTHDLFVSNQGNLPEIDERL-----EKLRRSIKAKDGYGLVLD 58
            :..||.||..:..:.|.  |:.|.:.|...|..:...:...|     |:.:..|::.|...|..|
  Rat   108 LQQEDKQKKKIARVGFNASSILRKNQLGFLNFSSYCRLSHELRVACMERKKVEIQSSDPSALASD 172

  Fly    59 KVAKIGEARKASGAQTPGDKTLAITDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVR 123
            :...|       .|.|..|:...:.|      ....||  ||...:....|........|.:|..
  Rat   173 RFNFI-------LADTTSDRLFTVND------VKIGGS--KYGIISLQGLKAPTFEVHMHENLYF 222

  Fly   124 ASLANSNADMSANGAIASHLQL-------IPKKAPSIP-------------KP----------KW 158
            .:...::...::...:.||:.|       .|..|..:|             :|          .|
  Rat   223 TNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVSSHQAGTDQPGMLCSFRIPGAW 287

  Fly   159 HAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVI----------KIWD----LA------- 202
            ...|.|:               ...|..|:||...||:          ..|.    ||
  Rat   288 SCAWSLN---------------VQANNCFSTGLSRRVLLTNVVTGHRQSYWTNSDVLAQQFAVKT 337

  Fly   203 --------SGKL--------------KLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEY 245
                    ||::              |.:...|.|.|..|.|..:..||.:.....::|.|||..
  Rat   338 PLLFNGCRSGEIFAIDLRSPSQAKGWKATQIFHDSAVTSVQVFKEEQYLMASDMAGKIKLWDLRA 402

  Fly   246 NKVIRHYHGHLS--AVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNT-VASVVAQ 307
            .|.:|.|.||::  |...|.:|....:|...|:|...|||.:.....:.|:.....| .|::.:.
  Rat   403 TKCVRQYEGHVNEYAYLPLHMHEEEGILVAVGQDCYTRIWSLHDARLLRTIPSPCPTSKANIPSV 467

  Fly   308 ATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMF--ASASPDNIKQWR 367
            |.:|: :.|...:...|                     :.:...||.|  :|:.||.:|:.|
  Rat   468 AFSPR-LGGPRGAPGLL---------------------MAVQQDLYCFPYSSSCPDGLKEGR 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	54/255 (21%)
		WD40	164..458	CDD:238121	53/252 (21%)
		WD40 repeat	177..212	CDD:293791	12/77 (16%)
		WD40 repeat	218..254	CDD:293791	11/35 (31%)
		WD40 repeat	259..295	CDD:293791	9/35 (26%)
		WD40 repeat	302..337	CDD:293791	5/34 (15%)
		WD40 repeat	343..378	CDD:293791	8/27 (30%)
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
Dcaf4	XP_006240409.1	WD40 repeat	286..324	CDD:293791	9/52 (17%)
		WD40	<302..471	CDD:225201	39/168 (23%)
		WD40	<314..471	CDD:295369	35/156 (22%)
		WD40 repeat	329..368	CDD:293791	5/38 (13%)
		WD40 repeat	374..410	CDD:293791	11/35 (31%)
		WD40 repeat	418..454	CDD:293791	9/35 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910