DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and U3-55K

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001014529.1	Gene:	U3-55K / 3346176	FlyBaseID:	FBgn0053505	Length:	484	Species:	Drosophila melanogaster

Alignment Length:	428	Identity:	95/428 - (22%)
Similarity:	167/428 - (39%)	Gaps:	87/428 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 FVSNQG--NLPEIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQTPGDKTLA--ITDGS 86
            |.|::|  ..|: |:||...::          .|.::.| .||.:|.      |:.||  :....
  Fly    80 FSSDEGEEETPQ-DKRLRLAKQ----------YLSEIEK-QEAERAE------DRELAQSVEQRL 126

  Fly    87 ATDAASGAGSLVKYNAGA-RPAEKTAPLVTGTHTSLVRASLANSNADMSANGA------------ 138
            .|:.....|.|.:..||: :..|.:..|....|.:.:.|...:.:......||
  Fly   127 QTEYLDSVGKLRRNIAGSLKACESSRILKHKLHHTPICALALSPDGKFLYTGAKSQFLLKWCTET 191

  Fly   139 --------IASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRV 195
                    :.||     ::.|...|.      :.|.|||        |.:....::.|...|...
  Fly   192 GKVLEKSDVLSH-----REEPETGKK------RRSHVIS--------ICLSSDMKYLALAEGGPH 237

  Fly   196 IKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVY 260
            |:||...:.|...:|.||..:|.|:........|:|..:||.||.|.|:....:....||.:||.
  Fly   238 IQIWCPQTMKHIKTLKGHRDSVAGLVFRKGTHDLYSAAKDRSVKIWSLDEMAYVESLFGHQTAVT 302

  Fly   261 SLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLW 325
            |:........:...|.|.:.|||.: |:.:.....||.::: ..|....:...::|..|..:.||
  Fly   303 SIDALSRERAITAGGSDCSLRIWKI-TEESQLIYNGHKDSI-ECVKYINDEHFVSGGMDGAIGLW 365

  Fly   326 DLAAGKSVCT-----------LTNHKKSVRSIVLHPSLYMFASASPDN-IKQWRC-PEGK---FV 374
            .....|.:||           :.|...:: ::|::..|  .|:.|.|. ::.|:. |..:   .:
  Fly   366 SALKKKPICTTQLAHGVGENGVANWITAI-AVVVNTDL--VATGSCDGCVRLWQTNPNARKMNLI 427

  Fly   375 QNISGHTSIVNCMAANSEG--VLVSGGDNGTMFFWDWR 410
            |:|| ....:|.:|.|::|  :.|:.|....:..| ||
  Fly   428 QSIS-IAGFINGLAFNADGSKLFVATGQEHRLGRW-WR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	65/268 (24%)
		WD40	164..458	CDD:238121	65/265 (25%)
		WD40 repeat	177..212	CDD:293791	8/34 (24%)
		WD40 repeat	218..254	CDD:293791	9/35 (26%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	302..337	CDD:293791	8/45 (18%)
		WD40 repeat	343..378	CDD:293791	8/39 (21%)
		WD40 repeat	386..426	CDD:293791	8/27 (30%)
		WD40 repeat	433..457	CDD:293791
U3-55K	NP_001014529.1	Upf2	55..>125	CDD:281974	15/62 (24%)
		WD40	<150..484	CDD:225201	74/340 (22%)
		WD40	156..416	CDD:295369	59/283 (21%)
		WD40 repeat	163..203	CDD:293791	3/39 (8%)
		WD40 repeat	218..254	CDD:293791	10/43 (23%)
		WD40 repeat	259..295	CDD:293791	10/35 (29%)
		WD40 repeat	302..336	CDD:293791	7/34 (21%)
		WD40 repeat	342..379	CDD:293791	8/37 (22%)
		WD40 repeat	391..431	CDD:293791	8/42 (19%)
		WD40 repeat	436..461	CDD:293791	6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910