DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and fbxw11a

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_005173126.1	Gene:	fbxw11a / 334373	ZFINID:	ZDB-GENE-030131-6305	Length:	562	Species:	Danio rerio

Alignment Length:	313	Identity:	73/313 - (23%)
Similarity:	132/313 - (42%)	Gaps:	90/313 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 RVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTV------RGVAVST 224
            :|::||.|.|.|:..:  .....||:.|..:::||::||::..:|..|...|      .|:.|
Zfish   294 KVLTGHTGSVLCLQYD--ERVIVTGSSDSTVRVWDVSSGEVLNTLIHHNEAVLHLRFCNGLMV-- 354

  Fly   225 KHPYLFSCGEDRQVKCWDLEYNKVI---RHYHGHLSAVYSLALHPTID-----VLATSGRDSTAR 281
                  :|.:||.:..||:.....|   |...||.:||      ..:|     :::.|| |.|.:
Zfish   355 ------TCSKDRSIAVWDMASATDISLRRVLVGHRAAV------NVVDFDDKYIVSASG-DRTIK 406

  Fly   282 IWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSI 346
            :|...|...|.||.||...:|.:  |..:..:::||.|:|:||||:..|  .|
Zfish   407 VWSTSTCEFVRTLNGHKRGIACL--QYRDRLVVSGSSDNTIRLWDIECG--AC------------ 455

  Fly   347 VLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGVLVSGGDNGTMFFWDWRT 411
                                       ::.:.||..:|.|:..:::.: |||..:|.:..||.:.
Zfish   456 ---------------------------LRVLEGHEELVRCIRFDNKRI-VSGAYDGKIKVWDLQA 492

  Fly   412 GYNFQRFQAPVQPGS-------MDSEAGIFAMCFDQSGSRLITAEADKTIKVY 457
            ..:      |..|.|       ::....:|.:.||:  .::|::..|.||.::
Zfish   493 ALD------PRAPASTLCLRTLVEHSGRVFRLQFDE--FQIISSSHDDTILIW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	73/313 (23%)
		WD40	164..458	CDD:238121	73/313 (23%)
		WD40 repeat	177..212	CDD:293791	9/34 (26%)
		WD40 repeat	218..254	CDD:293791	9/38 (24%)
		WD40 repeat	259..295	CDD:293791	10/40 (25%)
		WD40 repeat	302..337	CDD:293791	12/34 (35%)
		WD40 repeat	343..378	CDD:293791	0/34 (0%)
		WD40 repeat	386..426	CDD:293791	9/39 (23%)
		WD40 repeat	433..457	CDD:293791	7/23 (30%)
fbxw11a	XP_005173126.1	Beta-TrCP_D	98..136	CDD:288940
		F-box-like	140..187	CDD:289689
		WD40	<247..541	CDD:225201	73/313 (23%)
		WD40	260..538	CDD:238121	73/313 (23%)
		WD40 repeat	263..298	CDD:293791	1/3 (33%)
		WD40 repeat	304..338	CDD:293791	9/35 (26%)
		WD40 repeat	343..380	CDD:293791	10/44 (23%)
		WD40 repeat	387..420	CDD:293791	9/33 (27%)
		WD40 repeat	426..460	CDD:293791	12/76 (16%)
		WD40 repeat	466..509	CDD:293791	11/49 (22%)
		WD40 repeat	515..537	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910