DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Strn4

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001100950.2	Gene:	Strn4 / 308392	RGDID:	1307030	Length:	759	Species:	Rattus norvegicus

Alignment Length:	337	Identity:	86/337 - (25%)
Similarity:	133/337 - (39%)	Gaps:	39/337 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 KPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDL---ASGKLKLSL------ 210
            |..:...|.....:..|...:|.:|.........|.:.|..:|:|:|   .:.|...:|
  Rat   427 KDAFKKTWNPKFTLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIH 491

  Fly   211 --TGHVSTVRGVAVSTKHPYLFSCGEDRQVKCW---DLE------YNKVIRH--YHGHLSAVYSL 262
              ..|...|..|.:.:...|.:|.|.|.::..|   ||.      |:..:..  ..||..||:.|
  Rat   492 AFRAHRGPVLAVTMGSNSEYCYSGGADARIHSWKIPDLNMDPYDGYDPSVLSCVLEGHGDAVWGL 556

  Fly   263 ALHPTIDVLATSGRDSTARIWDMRTKAN----VHTLTGHTNTVASVVAQATNPQIITGSHDS--T 321
            |..||...||:...|.|.||||..:..:    ...:.|......||...:|.|..:..|..|  |
  Rat   557 AFSPTSQRLASCSADGTIRIWDPSSSGSSCLCTFPMAGEHGIPTSVAFTSTEPAHVVASFRSGDT 621

  Fly   322 VRLWDLAAGKSVCTLTNHKKS----VRSIVLHPSLYMFASASPD-NIKQWRCPEGKFVQNISGHT 381
            | |:||.||.::.||.:...|    :..:|.||:..:..:|..| .|:......||.|.::..|.
  Rat   622 V-LYDLEAGGALLTLESRGSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKSVHSMVAHL 685

  Fly   382 SIVNCMAANSEGV-LVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRL 445
            ..|.|:|.:..|| |:||..:.::..|........|...|    .....|..|.|:....|.:.:
  Rat   686 DAVTCLAVDPNGVFLMSGSHDCSLRLWSLDNKTCVQEITA----HRKKHEEAIHAVACHPSKALI 746

  Fly   446 ITAEADKTIKVY 457
            .:|.||...||:
  Rat   747 ASAGADALAKVF 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	85/331 (26%)
		WD40	164..458	CDD:238121	84/328 (26%)
		WD40 repeat	177..212	CDD:293791	8/45 (18%)
		WD40 repeat	218..254	CDD:293791	9/46 (20%)
		WD40 repeat	259..295	CDD:293791	13/39 (33%)
		WD40 repeat	302..337	CDD:293791	14/36 (39%)
		WD40 repeat	343..378	CDD:293791	9/35 (26%)
		WD40 repeat	386..426	CDD:293791	10/40 (25%)
		WD40 repeat	433..457	CDD:293791	7/23 (30%)
Strn4	NP_001100950.2	Striatin	63..188	CDD:285445
		WD40	422..>752	CDD:225201	82/329 (25%)
		WD40	436..758	CDD:238121	83/326 (25%)
		WD40 repeat	449..495	CDD:293791	8/45 (18%)
		WD40 repeat	501..548	CDD:293791	9/46 (20%)
		WD40 repeat	553..591	CDD:293791	13/37 (35%)
		WD40 repeat	600..636	CDD:293791	14/36 (39%)
		WD40 repeat	646..682	CDD:293791	9/35 (26%)
		WD40 repeat	688..727	CDD:293791	11/42 (26%)
		WD40 repeat	734..758	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910