DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Wdr5b

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001019937.1	Gene:	Wdr5b / 303907	RGDID:	1308567	Length:	328	Species:	Rattus norvegicus

Alignment Length:	321	Identity:	83/321 - (25%)
Similarity:	150/321 - (46%)	Gaps:	18/321 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 PKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLT 211
            |::.....||.    :.|...::||...:..:...|..||.|:.|.|.:|.||....||.|.:|.
  Rat    18 PQRVEEPQKPN----YALRLTLAGHSAAISSVKFSPNGEWLASSAADALIIIWGAYDGKCKKTLY 78

  Fly   212 GHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGR 276
            ||...:..||.|:....|.|..:|:.:|.||:...|.::...||...|:....:|..:::.:...
  Rat    79 GHSLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSDFVFCCDFNPPSNLIVSGSF 143

  Fly   277 DSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNH-K 340
            |.:.:||:::|...:.||:.|::.:::|........|::||:|...|:||.|:|:.:.||.:. .
  Rat   144 DESVKIWEVKTGKCLKTLSAHSDPISAVHFHCNGSLIVSGSYDGLCRIWDAASGQCLRTLADEGN 208

  Fly   341 KSVRSIVLHPS-LYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAAN----SEGVLVSGGD 400
            ..|..:...|: .|:..:.....:|.|....|:.::..:||.:...|:.|:    ....:|||.:
  Rat   209 PPVSFVKFSPNGKYILTATLDSTLKLWDYSRGRCLKTYTGHKNEKYCIFASFSVTGRKWVVSGSE 273

  Fly   401 NGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITA-EADKTIKVYKED 460
            :..::.|:.:|....||.|.       .::..|.|.|..........| |.|||||::..|
  Rat   274 DNMVYIWNLQTKEIVQRLQG-------HTDVVISAACHPTENIIASAALENDKTIKIWSSD 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	79/303 (26%)
		WD40	164..458	CDD:238121	79/300 (26%)
		WD40 repeat	177..212	CDD:293791	13/34 (38%)
		WD40 repeat	218..254	CDD:293791	10/35 (29%)
		WD40 repeat	259..295	CDD:293791	7/35 (20%)
		WD40 repeat	302..337	CDD:293791	11/34 (32%)
		WD40 repeat	343..378	CDD:293791	6/35 (17%)
		WD40 repeat	386..426	CDD:293791	10/43 (23%)
		WD40 repeat	433..457	CDD:293791	10/24 (42%)
Wdr5b	NP_001019937.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		1/4 (25%)
		WD40	31..325	CDD:238121	79/300 (26%)
		WD40	<34..325	CDD:225201	78/297 (26%)
		WD 1	37..76		14/38 (37%)
		WD40 repeat	42..79	CDD:293791	13/36 (36%)
		WD 2	79..120		12/40 (30%)
		WD40 repeat	85..121	CDD:293791	10/35 (29%)
		WD 3	122..162		8/39 (21%)
		WD40 repeat	126..162	CDD:293791	7/35 (20%)
		WD 4	163..202		11/38 (29%)
		WD40 repeat	169..204	CDD:293791	11/34 (32%)
		DDB1-binding motif	186..190		1/3 (33%)
		WD 5	206..247		6/40 (15%)
		WD40 repeat	211..247	CDD:293791	6/35 (17%)
		WD 6	250..290		7/39 (18%)
		WD40 repeat	255..292	CDD:293791	9/36 (25%)
		WD 7	293..328		11/42 (26%)
		WD40 repeat	298..324	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920