DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Tbl1x

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001100434.1	Gene:	Tbl1x / 302711	RGDID:	1563868	Length:	527	Species:	Rattus norvegicus

Alignment Length:	434	Identity:	94/434 - (21%)
Similarity:	145/434 - (33%)	Gaps:	140/434 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 NAGARPAEKTAPLVTGTHTSLVRASLAN--SNADMSANG------AIASH---------LQLIPK 148
            ||.|..|...|...:...|:...|:..|  .|.:.:.||      ||.:|         :::.|.
  Rat   109 NAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPS 173

  Fly   149 KAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDL------------ 201
            ||               .|:.||...|...|..|.::..|:|:||...:||:|
  Rat   174 KA---------------TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 223

  Fly   202 -------------------------------------------ASGKLKLSLTGHVSTVRGVAVS 223
                                                       ..|.|..:|..|...:..:..:
  Rat   224 LRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWN 288

  Fly   224 TKHPYLFSCGEDRQVKCWD-----------------------------------------LEYNK 247
            .|..|:.|.|.|:....||                                         |..::
  Rat   289 KKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 353

  Fly   248 VIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNP- 311
            .::.:.||.:.|.::...|:..:||:...|.|.:||.|:..|.||.|..|:..:.::....|.|
  Rat   354 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 418

  Fly   312 --------QIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDN-IKQWR 367
                    .:.:.|.||||||||:..|..:.|||.|::.|.|:...|.....||.|.|. :..|.
  Rat   419 TSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 483

  Fly   368 CPEGKFVQNISGHTSIVN-CMAANSEGVLVSGGDNGTMFFWDWR 410
            ...|..|.:..|...|.. |..|..:.|..|..| |::...|.|
  Rat   484 TQSGSLVHSYRGTGGIFEVCWNARGDKVGASASD-GSVCVLDLR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	77/357 (22%)
		WD40	164..458	CDD:238121	77/354 (22%)
		WD40 repeat	177..212	CDD:293791	12/89 (13%)
		WD40 repeat	218..254	CDD:293791	8/76 (11%)
		WD40 repeat	259..295	CDD:293791	12/35 (34%)
		WD40 repeat	302..337	CDD:293791	13/43 (30%)
		WD40 repeat	343..378	CDD:293791	10/35 (29%)
		WD40 repeat	386..426	CDD:293791	8/25 (32%)
		WD40 repeat	433..457	CDD:293791
Tbl1x	NP_001100434.1	LisH	7..31	CDD:369916
		WD40	177..483	CDD:238121	64/305 (21%)
		WD40 repeat	185..232	CDD:293791	10/46 (22%)
		WD40 repeat	242..277	CDD:293791	3/34 (9%)
		WD40 repeat	282..318	CDD:293791	7/35 (20%)
		WD40 repeat	325..359	CDD:293791	1/33 (3%)
		WD40 repeat	365..401	CDD:293791	12/35 (34%)
		WD40 repeat	407..452	CDD:293791	13/44 (30%)
		WD40 repeat	458..482	CDD:293791	7/23 (30%)
		WD40 repeat	499..525	CDD:293791	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010