DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and STRN3

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001077362.1	Gene:	STRN3 / 29966	HGNCID:	15720	Length:	797	Species:	Homo sapiens

Alignment Length:	554	Identity:	118/554 - (21%)
Similarity:	197/554 - (35%)	Gaps:	163/554 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 VSNQG------NLPEIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQTPGDKTLAITDG 85
            :.|:|      :.|:.:|.|::....:.|:||.|        .|||| :||..|..||.......
Human   283 IGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEG--------AGEAR-SSGDGTEWDKDDLSPTA 338

  Fly    86 SATDAASGAGSLVKY--------NAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASH 142
            ...|...|..|.:|.        ..|.:.|.:|              .|.:..||:..:
Human   339 EVWDVDQGLISKLKEQYKKERKGKKGVKRANRT--------------KLYDMIADLGDD------ 383

  Fly   143 LQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEP------GNEWFATGAGDRVIKI--- 198
                  :.|.||....:.....|..::.|.| .|....||      |.:.|..|:.|.::.:
Human   384 ------ELPHIPSGIINQSRSASTRMTDHEG-ARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGL 441

  Fly   199 ---------------WDLASGK--------LKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKC 240
                           :||.:.|        .|.:|..|...||.:|.....|.|.:..||..:|.
Human   442 GDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKL 506

  Fly   241 WDLEYN-----------KVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRT------- 287
            |:|:..           :.|..:..|:..|.|||:....:...:.|.|:|.:.|:|.:
Human   507 WNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYD 571

  Fly   288 --KANV--HTLTGHTNTVASVVAQATNPQIITGSHDSTVRLW----------------------- 325
              :.||  .||.|||:.|..:.......|:::.|.|.|||||
Human   572 TYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTS 636

  Fly   326 -----------------------DLAAGKSVCTLTNHKKS-------VRSIVLHPSLYMFASASP 360
                                   ||...:|:..|::...|       :..:|.||:|.:..:|..
Human   637 VDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHE 701

  Fly   361 D-NIKQWRCPEGKFVQNISGHTSIVNCMAANSEGV-LVSGGDNGTMFFWDWRTGYNFQRFQAPVQ 423
            | :||.:....||.:.::..|...|..:|.:..|: |:||..:.::..|:..:....|...|  .
Human   702 DRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITA--H 764

  Fly   424 PGSMDSEAGIFAMCFDQSGSRLITAEADKTIKVY 457
            ...:|.  .|:.:.|..|.:.:.:|.||...||:
Human   765 RKKLDE--SIYDVAFHSSKAYIASAGADALAKVF 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	87/406 (21%)
		WD40	164..458	CDD:238121	87/403 (22%)
		WD40 repeat	177..212	CDD:293791	11/66 (17%)
		WD40 repeat	218..254	CDD:293791	10/46 (22%)
		WD40 repeat	259..295	CDD:293791	12/46 (26%)
		WD40 repeat	302..337	CDD:293791	11/80 (14%)
		WD40 repeat	343..378	CDD:293791	10/35 (29%)
		WD40 repeat	386..426	CDD:293791	8/40 (20%)
		WD40 repeat	433..457	CDD:293791	7/23 (30%)
STRN3	NP_001077362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		Striatin	64..190	CDD:285445
		Caveolin-binding. /evidence=ECO:0000255	71..79
		Calmodulin-binding. /evidence=ECO:0000255	166..183
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..278
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	313..338		12/33 (36%)
		WD40	473..>790	CDD:225201	70/320 (22%)
		WD40	475..796	CDD:238121	72/324 (22%)
		WD 1	478..517		11/38 (29%)
		WD40 repeat	485..531	CDD:293791	9/45 (20%)
		WD 2	531..570		10/38 (26%)
		WD40 repeat	537..584	CDD:293791	12/46 (26%)
		WD 3	584..623		12/38 (32%)
		WD40 repeat	589..626	CDD:293791	9/36 (25%)
		WD40 repeat	635..671	CDD:293791	3/35 (9%)
		WD 4	679..718		10/38 (26%)
		WD40 repeat	684..720	CDD:293791	10/35 (29%)
		WD 5	721..760		8/38 (21%)
		WD40 repeat	726..765	CDD:293791	9/40 (23%)
		WD 6	767..796		8/30 (27%)
		WD40 repeat	772..796	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910