DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tango4 and Cop1

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_036061.1 Gene:Cop1 / 26374 MGIID:1347046 Length:733 Species:Mus musculus


Alignment Length:557 Identity:107/557 - (19%)
Similarity:198/557 - (35%) Gaps:147/557 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 HSVHTLIFRSLKRTHDLFVSNQGN--LPEIDERLEKL---RRSIKAKDGYG---LVLD--KVAKI 63
            |||.:......:...||..::|.|  |..::..||.|   ::.::|:....   ::::  |||:.
Mouse   211 HSVSSTNGHRWQIFQDLLGTDQDNLDLANVNLMLELLVQKKKQLEAESHAAQLQILMEFLKVARR 275

  Fly    64 GEARKASGAQTPGDKTLAI--TDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASL 126
            .:..:....|    |.|::  .|....:..||..|.|..::.....|..:|    :|:|::.::.
Mouse   276 NKREQLEQIQ----KELSVLEEDIKRVEEMSGLYSPVSEDSTVPQFEAPSP----SHSSIIDSTE 332

  Fly   127 ANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSR--VISGHL-GWVRCIAVEPGNEWFA 188
            .:.....|....        .||.|      |:.....||  .::.|. ...:|        :|:
Mouse   333 YSQPPGFSGTSQ--------TKKQP------WYNSTLASRRKRLTAHFEDLEQC--------YFS 375

  Fly   189 TGAGDRVIKIWD--------------------------LASGKLKLSLTGHVSTVRGVAVSTKHP 227
            |    |:.:|.|                          ||:......|....|.|..:.......
Mouse   376 T----RMSRISDDSRTASQLDEFQECLSKFTRYNSVRPLATLSYASDLYNGSSIVSSIEFDRDCD 436

  Fly   228 YLFSCGEDRQVKCWDLEYNKVIR-----HY-------HGHLSAVYSLALHPTIDVLATSGRDSTA 280
            |....|..:::|.:  ||..||:     ||       :..:|.:...:.|.  ::||:|..:.|.
Mouse   437 YFAIAGVTKKIKVY--EYGTVIQDAVDIHYPENEMTCNSKISCISWSSYHK--NLLASSDYEGTV 497

  Fly   281 RIWDMRTKANVHTLTGHTNTVASVVAQATNPQII-TGSHDSTVRLW---------DLAAGKSVC- 334
            .:||..|.........|.....||.....:|::: :||.|:.|:||         .:.|..:|| 
Mouse   498 ILWDGFTGQRSKVYQEHEKRCWSVDFNLMDPKLLASGSDDAKVKLWSTNLDNSVASIEAKANVCC 562

  Fly   335 -----------------------TLTNHKKSVRSIVLHPSLYMFA---------SASPDN-IKQW 366
                                   .|.|.|:.:.....|.....:|         |||.|: :|.|
Mouse   563 VKFSPSSRYHLAFGCADHCVHYYDLRNTKQPIMVFKGHRKAVSYAKFVSGEEIVSASTDSQLKLW 627

  Fly   367 RCPEGKFVQNISGHTSIVNCMAANSEG-VLVSGGDNGTMFFW-----DWRTGYNFQRFQAPVQPG 425
            ...:...:::..||.:..|.:...|.| .:..|.:|.:::.:     .....:.|...::.:...
Mouse   628 NVGKPYCLRSFKGHINEKNFVGLASNGDYIACGSENNSLYLYYKGLSKTLLTFKFDTVKSVLDKD 692

  Fly   426 SMDSEAGIF--AMCF----DQSGSRLITAEADKTIKV 456
            ..:.:...|  |:|:    |...:.||.|.:..||||
Mouse   693 RKEDDTNEFVSAVCWRALSDGESNVLIAANSQGTIKV 729

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 75/393 (19%)
WD40 164..458 CDD:238121 75/390 (19%)
WD40 repeat 177..212 CDD:293791 9/60 (15%)
WD40 repeat 218..254 CDD:293791 9/47 (19%)
WD40 repeat 259..295 CDD:293791 8/35 (23%)
WD40 repeat 302..337 CDD:293791 12/68 (18%)
WD40 repeat 343..378 CDD:293791 8/44 (18%)
WD40 repeat 386..426 CDD:293791 5/45 (11%)
WD40 repeat 433..457 CDD:293791 11/30 (37%)
Cop1NP_036061.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..43
Nuclear localization signal 1 111..115
zf-C3HC4 138..175 CDD:278524
Nuclear localization signal 2 197..208
Nuclear export signal 237..247 3/9 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..327 4/23 (17%)
WD 1 421..460 9/40 (23%)
WD40 423..729 CDD:238121 61/309 (20%)
WD 2 470..510 9/41 (22%)
WD40 repeat 475..512 CDD:293791 9/38 (24%)
WD 3 513..553 10/39 (26%)
WD40 repeat 519..555 CDD:293791 9/35 (26%)
WD 4 555..595 6/39 (15%)
WD40 repeat 560..598 CDD:293791 5/37 (14%)
WD 5 599..637 8/37 (22%)
WD40 repeat 604..643 CDD:293791 9/38 (24%)
WD 6 640..679 7/38 (18%)
Interaction with TRIB1. /evidence=ECO:0000250|UniProtKB:Q8NHY2 645..647 0/1 (0%)
WD40 repeat 647..669 CDD:293791 4/21 (19%)
WD 7 695..731 11/35 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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