DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tango4 and DCAF4

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_001339378.1 Gene:DCAF4 / 26094 HGNCID:20229 Length:496 Species:Homo sapiens


Alignment Length:333 Identity:62/333 - (18%)
Similarity:103/333 - (30%) Gaps:116/333 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 RLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQTPGDKTLAITDGSATDAASGAGSLVKYNAG 103
            ::..:..|..|.|.:.|:|              |.|..|:...:.|      ....||  ||...
Human   160 QIRSMDPSALASDRFNLIL--------------ADTNSDRLFTVND------VKVGGS--KYGII 202

  Fly   104 ARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQL-------IPKKAPSIP------- 154
            ...:.||..|....|.:|...:...::...::...:.||:.|       .|..|..:|       
Human   203 NLQSLKTPTLKVFMHENLYFTNRKVNSVCWASLNHLDSHILLCLMGLAETPGCATLLPASLFVNS 267

  Fly   155 ------KP----------KWHAPWK------------------LSRVISGH-------------- 171
                  :|          .|...|.                  |:.|::||              
Human   268 HPAGIDRPGMLCSFRIPGAWSCAWSLNIQANNCFSTGLSRRVLLTNVVTGHRQSFGTNSDVLAQQ 332

  Fly   172 -------------LGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVS 223
                         .|.:..|.:..||:    |.|.:..:::             |.|.|..|.:.
Human   333 FALMAPLLFNGCRSGEIFAIDLRCGNQ----GKGWKATRLF-------------HDSAVTSVRIL 380

  Fly   224 TKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLS--AVYSLALHPTIDVLATSGRDSTARIWDMR 286
            ....||.:.....::|.|||...|.:|.|.||::  |...|.:|....:|...|:|...|||.:.
Human   381 QDEQYLMASDMAGKIKLWDLRTTKCVRQYEGHVNEYAYLPLHVHEEEGILVAVGQDCYTRIWSLH 445

  Fly   287 TKANVHTL 294
            ....:.|:
Human   446 DARLLRTI 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 36/181 (20%)
WD40 164..458 CDD:238121 35/160 (22%)
WD40 repeat 177..212 CDD:293791 5/34 (15%)
WD40 repeat 218..254 CDD:293791 10/35 (29%)
WD40 repeat 259..295 CDD:293791 9/36 (25%)
WD40 repeat 302..337 CDD:293791
WD40 repeat 343..378 CDD:293791
WD40 repeat 386..426 CDD:293791
WD40 repeat 433..457 CDD:293791
DCAF4NP_001339378.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..66
WD40 repeat 286..323 CDD:293791 6/36 (17%)
WD40 <287..470 CDD:330360 37/184 (20%)
WD40 repeat 329..368 CDD:293791 6/42 (14%)
WD 1 369..408 11/51 (22%)
WD40 repeat 374..410 CDD:293791 10/35 (29%)
WD 2 411..452 11/40 (28%)
WD40 repeat 418..454 CDD:293791 9/36 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.