DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and Aamp

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001177373.1	Gene:	Aamp / 227290	MGIID:	107809	Length:	436	Species:	Mus musculus

Alignment Length:	336	Identity:	76/336 - (22%)
Similarity:	118/336 - (35%)	Gaps:	62/336 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 PGDKTLAITDGSATDA---ASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSAN 136
            |...|||:|.|....|   ..|.|.|:...||.:.:...|..   :|.|.:.|:     .|||
Mouse   103 PKTNTLAVTGGEDDKAFVWRLGDGELLFECAGHKDSVTCAGF---SHDSTLVAT-----GDMS-- 157

  Fly   137 GAIASHLQLIPK------KAPSIPKPKWH--APWKLSRVISGHLGWV------------------ 175
             .:....|:..|      :|..:...:||  ||..|:....|:. |:
Mouse   158 -GLLKVWQVDTKEEVWSFEAGDLEWMEWHPRAPVLLAGTADGNT-WMWKVPNGDCKTFQGPNCPA 220

  Fly   176 RCIAVEPGNEWFATGAGDRVIKIWDLASGK----LKLSLTGHVSTVRGVAVSTKHPYLFSCGEDR 236
            .|..|.|..:....|..|..|:||||..|.    || ...||...:..||.:.....:.:...|.
Mouse   221 TCGRVLPDGKRAVVGYEDGTIRIWDLKQGNPIHVLK-GTEGHQGPLTCVATNQDGSLILTGSVDC 284

  Fly   237 QVKCWDLEYNKVIRHY---------------HGHLSAVYSLALHPTIDVLATSGRDSTARIWDMR 286
            |.|.......||:..:               ....::|.||.....:.:.|....|.|..|:|:.
Mouse   285 QAKLVSATTGKVVGVFRPETVASQPSLGEGEESESNSVESLGFCSVMPLAAVGYLDGTLAIYDLS 349

  Fly   287 TKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPS 351
            |:...|... |.:.:..::.:|....:.|.|.|..|||||...|:.:.....|...:....|...
Mouse   350 TQTLRHQCQ-HQSGIVQLLWEAGTAVVYTCSLDGVVRLWDARTGRLLTDYRGHTAEILDFALSKD 413

  Fly   352 LYMFASASPDN 362
            ..:..:.|.|:
Mouse   414 ASLVVTTSGDH 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	51/239 (21%)
		WD40	164..458	CDD:238121	50/236 (21%)
		WD40 repeat	177..212	CDD:293791	13/38 (34%)
		WD40 repeat	218..254	CDD:293791	7/50 (14%)
		WD40 repeat	259..295	CDD:293791	10/35 (29%)
		WD40 repeat	302..337	CDD:293791	10/34 (29%)
		WD40 repeat	343..378	CDD:293791	3/20 (15%)
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
Aamp	NP_001177373.1	WD40	88..388	CDD:238121	69/298 (23%)
		WD40	<91..432	CDD:225201	76/336 (23%)
		WD40 repeat	97..134	CDD:293791	10/30 (33%)
		WD40 repeat	139..177	CDD:293791	9/48 (19%)
		WD40 repeat	178..215	CDD:293791	7/37 (19%)
		WD40 repeat	220..256	CDD:293791	11/35 (31%)
		WD40 repeat	266..302	CDD:293791	7/35 (20%)
		WD40 repeat	309..354	CDD:293791	9/44 (20%)
		WD40 repeat	363..399	CDD:293791	10/35 (29%)
		WD40	391..429	CDD:197651	5/34 (15%)
		WD40 repeat	405..429	CDD:293791	3/20 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920