DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tango4 and Tle4

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_001289876.1 Gene:Tle4 / 21888 MGIID:104633 Length:774 Species:Mus musculus


Alignment Length:493 Identity:105/493 - (21%)
Similarity:162/493 - (32%) Gaps:161/493 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 VLDKVAKIGEARKASGAQTPGDKT--LAITDGSA------------TDAAS-GAGSLVKYNAGAR 105
            :|.|.|.|..|..||.:.||..|:  |::.:.|.            |||.: |:.|    ..|.|
Mouse   285 LLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNS----TPGLR 345

  Fly   106 PAEKTAPLVTGTHTSL-------------------------------VRASLANSNADMSANGAI 139
            |.....|.|....:||                               ..|.|.|.:..|||..|.
Mouse   346 PVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAA 410

  Fly   140 AS-----------------HLQL--IPKKAPSIP--KP--KWHA--------------------- 160
            |:                 |:::  ||.....||  ||  .:|.                     
Mouse   411 AAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGI 475

  Fly   161 PWKLSRVISGHLGWVRCIAV--EPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVS 223
            |....::.:.:.|.|.|...  .|....:..|.|  .:|:||       :|..|:.|.|..:...
Mouse   476 PRHARQINTLNHGEVVCAVTISNPTRHVYTGGKG--CVKVWD-------ISHPGNKSPVSQLDCL 531

  Fly   224 TKHPYLFSC------------GEDRQVKCWDL--EYNKVIRHYHGHLSAVYSLALHPTIDVLATS 274
            .:..|:.||            ||...:..|||  ...::.........|.|:||:.|...|..:.
Mouse   532 NRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSC 596

  Fly   275 GRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSV------ 333
            ..|....:||:..:..|....|||:..:.:.......::.||..|:|||.|||..|:.:      
Mouse   597 CSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFT 661

  Fly   334 --------CT--------LTNHKKSVRSIV--------LHPSLYM----------FASASPDN-I 363
                    |.        :.|....|..:.        ||.|..:          |.|...|| :
Mouse   662 SQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLL 726

  Fly   364 KQWRCPEGKFVQNISGHTSIVNCMAANSEGVLVSG-GD 400
            ..||.|.|..:......:|:::|..:..:..:|:| ||
Mouse   727 NAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGD 764

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 65/298 (22%)
WD40 164..458 CDD:238121 64/295 (22%)
WD40 repeat 177..212 CDD:293791 8/36 (22%)
WD40 repeat 218..254 CDD:293791 8/49 (16%)
WD40 repeat 259..295 CDD:293791 9/35 (26%)
WD40 repeat 302..337 CDD:293791 11/56 (20%)
WD40 repeat 343..378 CDD:293791 12/53 (23%)
WD40 repeat 386..426 CDD:293791 5/16 (31%)
WD40 repeat 433..457 CDD:293791
Tle4NP_001289876.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
TLE_N 16..139 CDD:397828
GP domain. /evidence=ECO:0000250|UniProtKB:Q04727 138..205
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 141..163
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 183..358 22/76 (29%)
CcN domain. /evidence=ECO:0000250|UniProtKB:Q04727 206..275
SP domain. /evidence=ECO:0000250|UniProtKB:Q04727 276..453 39/171 (23%)
WD 1 486..524 11/46 (24%)
WD40 487..771 CDD:238121 64/287 (22%)
WD40 repeat 491..530 CDD:293791 11/47 (23%)
WD 2 532..571 8/38 (21%)
WD40 repeat 538..576 CDD:293791 7/37 (19%)
WD 3 576..615 10/38 (26%)
WD40 repeat 581..617 CDD:293791 9/35 (26%)
WD 4 618..657 13/38 (34%)
WD40 repeat 624..659 CDD:293791 10/34 (29%)
WD 5 659..698 3/38 (8%)
WD40 repeat 664..697 CDD:293791 3/32 (9%)
WD 6 700..739 11/38 (29%)
WD40 repeat 705..739 CDD:293791 8/33 (24%)
WD 7 741..774 6/24 (25%)
WD40 repeat 746..770 CDD:293791 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.