DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tango4 and Tle3

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_001077396.1 Gene:Tle3 / 21887 MGIID:104634 Length:782 Species:Mus musculus


Alignment Length:381 Identity:88/381 - (23%)
Similarity:140/381 - (36%) Gaps:88/381 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 SATDAASGAGSLVKYNAGARPAEKTAPL-VTGTHTSLVRASLANSNADMSANGAIASHLQLIP-- 147
            :|..||.|...:|.:  ||...:...|: .||..:||  ||:.......|.:.:....:|.:|  
Mouse   414 AAAAAAYGRSPMVSF--GAVGFDPHPPMRATGLPSSL--ASIPGGKPAYSFHVSADGQMQPVPFP 474

  Fly   148 ---KKAPSIPKPKWHAPWKLSRVIS--GHLGWVRCIAV--EPGNEWFATGAGDRVIKIWDLASGK 205
               ...|.||:   ||     |.|:  .| |.|.|...  .|....:..|.|  .:||||     
Mouse   475 HDALAGPGIPR---HA-----RQINTLSH-GEVVCAVTISNPTRHVYTGGKG--CVKIWD----- 523

  Fly   206 LKLSLTGHVSTVRGVAVSTKHPYLFSC------------GEDRQVKCWDL--EYNKVIRHYHGHL 256
              :|..|..|.:..:....:..|:.||            ||...:..|||  ...::........
Mouse   524 --ISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSA 586

  Fly   257 SAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDST 321
            .|.|:||:.|...|..:...|....:||:..:..|....|||:..:.:.......::.||..|:|
Mouse   587 PACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNT 651

  Fly   322 VRLWDLAAGK------------------------------SVCTLTNHKKSVRSIVLHPSLYM-- 354
            ||.|||..|:                              :|..|.:.|.....:.||.|..:  
Mouse   652 VRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSL 716

  Fly   355 --------FASASPDN-IKQWRCPEGKFVQNISGHTSIVNC-MAANSEGVLVSGGD 400
                    |.|...|| :..||.|.|..:......:|:::| ::|:.:.::...||
Mouse   717 KFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGD 772

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 66/300 (22%)
WD40 164..458 CDD:238121 66/297 (22%)
WD40 repeat 177..212 CDD:293791 9/36 (25%)
WD40 repeat 218..254 CDD:293791 8/49 (16%)
WD40 repeat 259..295 CDD:293791 9/35 (26%)
WD40 repeat 302..337 CDD:293791 11/64 (17%)
WD40 repeat 343..378 CDD:293791 11/45 (24%)
WD40 repeat 386..426 CDD:293791 4/16 (25%)
WD40 repeat 433..457 CDD:293791
Tle3NP_001077396.1 TLE_N 9..143 CDD:397828
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 140..173
GP domain. /evidence=ECO:0000250|UniProtKB:Q04724 142..209
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..357
CcN domain. /evidence=ECO:0000250|UniProtKB:Q04724 210..278
Nuclear localization signal. /evidence=ECO:0000255 235..238
Herpes_BLLF1 <261..482 CDD:282904 17/71 (24%)
SP domain. /evidence=ECO:0000250|UniProtKB:Q04724 279..462 15/51 (29%)
WD40 494..779 CDD:238121 64/289 (22%)
WD 1 494..532 13/47 (28%)
WD40 repeat 499..538 CDD:293791 11/47 (23%)
WD 2 540..579 8/38 (21%)
WD40 repeat 546..584 CDD:293791 7/37 (19%)
WD 3 584..623 10/38 (26%)
WD40 repeat 589..625 CDD:293791 9/35 (26%)
WD 4 626..665 13/38 (34%)
WD40 repeat 632..667 CDD:293791 10/34 (29%)
WD 5 667..706 3/38 (8%)
WD40 repeat 672..705 CDD:293791 3/32 (9%)
WD 6 708..747 11/38 (29%)
WD40 repeat 713..747 CDD:293791 8/33 (24%)
WD 7 749..781 5/24 (21%)
WD40 repeat 754..778 CDD:293791 4/19 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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