DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tango4 and Tle2

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:XP_011241731.1 Gene:Tle2 / 21886 MGIID:104635 Length:843 Species:Mus musculus


Alignment Length:583 Identity:110/583 - (18%)
Similarity:170/583 - (29%) Gaps:239/583 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    50 KDGYGLVLDK----------VAKIGEA-----------------RKASGAQTPGDKTLAITD--- 84
            |..|.||:|:          ....|:|                 ..:.|:..|..|.:|:.|   
Mouse   257 KSDYNLVVDEDQPSEPPSPVTTPCGKAPLCIPARRDLTDSPASLASSLGSPLPRSKDIALNDLPT 321

  Fly    85 --------------GSATDAASGAGSLVKYNAGARPAEKT------APLV----------TGTHT 119
                          .|:|...|.|..|.:  ..|:||..|      :||.          .|:|:
Mouse   322 GTPASRSCGTSPPQDSSTPGPSSASHLCQ--LAAQPAAPTDSIALRSPLTLSSPFTSSFSLGSHS 384

  Fly   120 SLVRASLANSNADMSANGAIAS--------------------------HLQLIPKKAPSIP--KP 156
            :|        |.|:|..|:...                          ||:......|.||  ||
Mouse   385 TL--------NGDLSMPGSYVGLHLSPQVSSSVVYGRSPLQMAFESHPHLRGSSVSLPGIPVAKP 441

  Fly   157 KWH-----------APWKLSRVISGHL------------GWVRC-IAVEPGNEWFATGAGDRVIK 197
            .:.           .|:....::...:            |.|.| :.:....:...|| |...:|
Mouse   442 AYSFHVSADGQMQPVPFPSDALVGTGIPRHARQLHTLAHGEVVCAVTISSSTQHVYTG-GKGCVK 505

  Fly   198 IWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSC------------GEDRQVKCWDL--EYNKV 248
            :||:..       .|..:.|..:....:..|:.||            ||...:..|||  ...::
Mouse   506 VWDVGQ-------PGSKTPVAQLDCLNRDNYIRSCKLLPDGQSLIVGGEASTLSIWDLAAPTPRI 563

  Fly   249 IRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQI 313
            .........|.|:||:.|...|..:...|....:||::.:|.|....|||:..:.:.......::
Mouse   564 KAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQAMVRQFQGHTDGASCIDISDYGTRL 628

  Fly   314 ITGSHDSTVRLWDLAAGKSV--------------CT----LTNHKKSVRSIVLH---PSLYM--- 354
            .||..|:|||.|||..|:.:              |.    |....:|....|||   |..|.   
Mouse   629 WTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSHVEVLHVRKPEKYQLRL 693

  Fly   355 ----------------FASASPDN-IKQWRCPEGKFVQNI-------------SGHT-------- 381
                            |.|...|| :..||.|.|..:..:             |.||        
Mouse   694 HESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQVTCPGWLATRDTGPSAHTWLAPSWLG 758

  Fly   382 ---------SIVN------CMAANSEGVLVSGGDNGTMFFWDWRTGY-----NFQRFQAPVQP 424
                     :.:|      |:....||.             ||.:.:     |||......:|
Mouse   759 GAGALGKYNTFINLLSFCVCVKRTGEGP-------------DWVSAFISLCPNFQSVDLTNEP 808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 73/373 (20%)
WD40 164..458 CDD:238121 72/370 (19%)
WD40 repeat 177..212 CDD:293791 7/35 (20%)
WD40 repeat 218..254 CDD:293791 8/49 (16%)
WD40 repeat 259..295 CDD:293791 10/35 (29%)
WD40 repeat 302..337 CDD:293791 11/52 (21%)
WD40 repeat 343..378 CDD:293791 13/70 (19%)
WD40 repeat 386..426 CDD:293791 9/44 (20%)
WD40 repeat 433..457 CDD:293791
Tle2XP_011241731.1 TLE_N 1..152 CDD:367727
PHA03247 <269..459 CDD:223021 33/199 (17%)
WD40 466..723 CDD:392136 55/264 (21%)
WD40 repeat 484..523 CDD:293791 9/46 (20%)
WD40 repeat 531..569 CDD:293791 7/37 (19%)
WD40 repeat 574..610 CDD:293791 10/35 (29%)
WD40 repeat 617..652 CDD:293791 10/34 (29%)
WD40 repeat 657..692 CDD:293791 8/34 (24%)
WD40 repeat 698..724 CDD:293791 5/25 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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