DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Tep1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_033377.1	Gene:	Tep1 / 21745	MGIID:	109573	Length:	2629	Species:	Mus musculus

Alignment Length:	491	Identity:	99/491 - (20%)
Similarity:	183/491 - (37%)	Gaps:	116/491 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 GY---GLVLDKVAKIGEARKASGAQTPGDKTLAIT-----------------DGS------ATDA 90
            ||   |:.:.|:        :||:|.|..:.|.:.                 |||      ..|:
Mouse  1952 GYREDGINIYKI--------SSGSQGPQHQELNVAVSALVWLSPSVLVSGAEDGSLHGWMFKGDS 2008

  Fly    91 ASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQLIPKKAPSIPK 155
            ......|.:|.   :|       |.|...|  |..:|.::.|.:        ::|.|::.  :.:
Mouse  2009 LHSLWLLSRYQ---KP-------VLGLAAS--RELMAAASEDFT--------VRLWPRQL--LTQ 2051

  Fly   156 PKWHA-PWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSL----TGHVS 215
            |..|| .......:.||.|.|.|.:..|.....||...||.:..||:...:..|.:    :.|..
Mouse  2052 PHVHAVELPCCAELRGHEGPVCCCSFSPDGGILATAGRDRNLLCWDMKIAQAPLLIHTFSSCHRD 2116

  Fly   216 TVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGH---LSAVYSLALHPTIDVLATSGRD 277
            .:.|.| .||...|.||..|..|..|:.|..:.:..:.||   :|||.::..|     :.:..||
Mouse  2117 WITGCA-WTKDNILVSCSSDGSVGLWNPEAGQQLGQFSGHQSAVSAVVAVEEH-----IVSVSRD 2175

  Fly   278 STARIWDMRTKANVHTLTGHTNTVASVVAQATNPQ----------IITGSHDSTVRLWDLAAGKS 332
            .|.::|| .....:.::..|:..: |..|.|..|:          ::|...|...:||.......
Mouse  2176 GTLKVWD-HQGVELTSIPAHSGPI-SQCAAALEPRPGGQPGSELLVVTVGLDGATKLWHPLLVCQ 2238

  Fly   333 VCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSI-VNCMAANSEG-VL 395
            :.||..|...|.:.....:..:..::...:::.|:.|: :...:....:|: :..:|...:| ::
Mouse  2239 IRTLQGHSGPVTAAAASEASGLLLTSDDSSVQLWQIPK-EADDSYKPRSSVAITAVAWAPDGSMV 2302

  Fly   396 VSGGDNGTMFFWD------------------WRTGYNF---------QRFQAPVQPGSMDSEAGI 433
            |||.:.|.:..|.                  |.:..:|         ..:|..::.||..:.:.:
Mouse  2303 VSGNEAGELTLWQQAKAVATAQAPGRVSHLIWYSANSFFVLSANENVSEWQVGLRKGSTSTSSSL 2367

  Fly   434 FAMCFDQSGSRLIT----AEADKTIKVYKEDDEASE 465
            ......|....::|    |...:::.:.|||.|..|
Mouse  2368 HLKRVLQEDWGVLTGLGLAPDGQSLILMKEDVELLE 2403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	67/346 (19%)
		WD40	164..458	CDD:238121	67/343 (20%)
		WD40 repeat	177..212	CDD:293791	9/38 (24%)
		WD40 repeat	218..254	CDD:293791	11/35 (31%)
		WD40 repeat	259..295	CDD:293791	7/35 (20%)
		WD40 repeat	302..337	CDD:293791	9/44 (20%)
		WD40 repeat	343..378	CDD:293791	3/34 (9%)
		WD40 repeat	386..426	CDD:293791	10/67 (15%)
		WD40 repeat	433..457	CDD:293791	3/27 (11%)
Tep1	NP_033377.1	TEP1 N-terminal 1	1..30
		TEP1_N	1..29	CDD:283129
		TEP1 N-terminal 2	31..60
		TEP1_N	31..59	CDD:283129
		TEP1 N-terminal 3	61..90
		TEP1_N	62..89	CDD:283129
		TEP1 N-terminal 4	91..120
		TEP1_N	91..119	CDD:283129
		TROVE	230..685	CDD:283406
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	386..412
		DUF4062	917..1017	CDD:290011
		NACHT	1171..1346	CDD:283404
		WD 1	1420..1462
		WD 2	1681..1720
		WD40 repeat	1687..1723	CDD:293791
		WD 3	1723..1761
		WD40 repeat	1729..1764	CDD:293791
		WD40	1763..2182	CDD:238121	61/265 (23%)
		WD 4	1764..1803
		WD40 repeat	1769..1804	CDD:293791
		WD 5	1805..1844
		WD40	1806..2198	CDD:225201	64/282 (23%)
		WD40 repeat	1811..1847	CDD:293791
		WD 6	1847..1886
		WD40 repeat	1852..1887	CDD:293791
		WD 7	1889..1930
		WD40 repeat	1895..1930	CDD:293791
		WD 8	1932..1971		7/26 (27%)
		WD40 repeat	1937..2066	CDD:293791	27/143 (19%)
		WD 9	1974..2013		5/38 (13%)
		WD40	1979..2273	CDD:238121	67/323 (21%)
		WD40 repeat	1979..2014	CDD:293791	4/34 (12%)
		WD 10	2015..2054		12/60 (20%)
		WD 11	2067..2106		12/38 (32%)
		WD40 repeat	2072..2111	CDD:293791	10/38 (26%)
		WD 12	2113..2151		12/38 (32%)
		WD40 repeat	2118..2141	CDD:293791	9/23 (39%)
		WD 13	2154..2191		11/42 (26%)
		WD40 repeat	2159..2190	CDD:293791	9/36 (25%)
		WD 14	2193..2241		9/48 (19%)
		WD40 repeat	2198..2243	CDD:293791	9/45 (20%)
		WD 15	2244..2282		4/38 (11%)
		WD40 repeat	2250..2272	CDD:293791	0/21 (0%)
		WD 16	2285..2324		8/38 (21%)
		WD40 repeat	2290..2322	CDD:293791	7/31 (23%)
		WD 17	2326..2362		5/35 (14%)
		WD40 repeat	2330..2374	CDD:293791	5/43 (12%)
		WD 18	2375..2424		7/29 (24%)
		WD40 repeat	2380..2410	CDD:293791	7/24 (29%)
		WD40	2408..>2625	CDD:225201
		WD40 repeat	2420..2465	CDD:293791
		WD 19	2467..2507
		WD40 repeat	2472..2495	CDD:293791
		WD40	<2534..>2602	CDD:295369
		WD 20	2555..2592
		WD 21	2594..2628
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910