DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tango4 and Tbl1x

DIOPT Version :9

Sequence 1:NP_572778.1 Gene:Tango4 / 32168 FlyBaseID:FBgn0030365 Length:482 Species:Drosophila melanogaster
Sequence 2:NP_065626.1 Gene:Tbl1x / 21372 MGIID:1336172 Length:527 Species:Mus musculus


Alignment Length:434 Identity:94/434 - (21%)
Similarity:145/434 - (33%) Gaps:140/434 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 NAGARPAEKTAPLVTGTHTSLVRASLAN--SNADMSANG------AIASH---------LQLIPK 148
            ||.|..|...|...:...|:...|:..|  .|.:.:.||      ||.:|         :::.|.
Mouse   109 NAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSKPMEIDGDVEIPPS 173

  Fly   149 KAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDL------------ 201
            ||               .|:.||...|...|..|.::..|:|:||...:||:|            
Mouse   174 KA---------------TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLV 223

  Fly   202 -------------------------------------------ASGKLKLSLTGHVSTVRGVAVS 223
                                                       ..|.|..:|..|...:..:..:
Mouse   224 LRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWN 288

  Fly   224 TKHPYLFSCGEDRQVKCWD-----------------------------------------LEYNK 247
            .|..|:.|.|.|:....||                                         |..::
Mouse   289 KKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDR 353

  Fly   248 VIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNP- 311
            .::.:.||.:.|.::...|:..:||:...|.|.:||.|:..|.||.|..|:..:.::....|.| 
Mouse   354 PVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPA 418

  Fly   312 --------QIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDN-IKQWR 367
                    .:.:.|.||||||||:..|..:.|||.|::.|.|:...|.....||.|.|. :..|.
Mouse   419 TSNPNSNIMLASASFDSTVRLWDVERGVCIHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWN 483

  Fly   368 CPEGKFVQNISGHTSIVN-CMAANSEGVLVSGGDNGTMFFWDWR 410
            ...|..|.:..|...|.. |..|..:.|..|..| |::...|.|
Mouse   484 TQSGSLVHSYRGTGGIFEVCWNARGDKVGASASD-GSVCVLDLR 526

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango4NP_572778.1 WD40 <161..458 CDD:225201 77/357 (22%)
WD40 164..458 CDD:238121 77/354 (22%)
WD40 repeat 177..212 CDD:293791 12/89 (13%)
WD40 repeat 218..254 CDD:293791 8/76 (11%)
WD40 repeat 259..295 CDD:293791 12/35 (34%)
WD40 repeat 302..337 CDD:293791 13/43 (30%)
WD40 repeat 343..378 CDD:293791 10/35 (29%)
WD40 repeat 386..426 CDD:293791 8/25 (32%)
WD40 repeat 433..457 CDD:293791
Tbl1xNP_065626.1 LisH 7..31 CDD:369916
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 127..164 9/36 (25%)
WD40 177..483 CDD:238121 64/305 (21%)
WD 1 180..219 12/38 (32%)
WD40 repeat 185..232 CDD:293791 10/46 (22%)
WD 2 236..275 2/38 (5%)
WD40 repeat 242..277 CDD:293791 3/34 (9%)
WD 3 277..316 8/38 (21%)
WD40 repeat 282..318 CDD:293791 7/35 (20%)
WD 4 319..359 1/39 (3%)
WD40 repeat 325..359 CDD:293791 1/33 (3%)
WD 5 360..399 13/38 (34%)
WD40 repeat 365..401 CDD:293791 12/35 (34%)
WD 6 402..450 13/47 (28%)
WD40 repeat 407..452 CDD:293791 13/44 (30%)
WD 7 453..492 11/38 (29%)
WD40 repeat 458..482 CDD:293791 7/23 (30%)
WD 8 494..526 9/32 (28%)
WD40 repeat 499..525 CDD:293791 7/26 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53955
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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