DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and F47D12.9

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_498382.2	Gene:	F47D12.9 / 175892	WormBaseID:	WBGene00018564	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	348	Identity:	69/348 - (19%)
Similarity:	132/348 - (37%)	Gaps:	78/348 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 EIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQTPGDKTLAIT-------DGSATDAAS 92
            |:|...:.::.....::.|.|:..:          |.:...|..||.:|       ||.:.:.:.
Worm   203 EVDSIGDTIQSESSRREAYQLLPIR----------SRSNNAGFNTLGLTVRPMLRDDGFSDEPSY 257

  Fly    93 GAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIAS----HLQLI-----PK 148
            ...::.:||:..  .::|...|....|.::..:   :|..::.||.:.|    ||:.:     |:
Worm   258 LDYAVTRYNSFI--VDQTLARVDADVTCMLTVT---ANDTITRNGNVCSYCTVHLEPLAELSDPE 317

  Fly   149 KAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEW--------FATGAG-DRVIKIWDLASG 204
            ..|::..|.::..|:                 |.||.|        .:.|.| :...::.:|.:.
Worm   318 AMPTLNSPIYNKSWR-----------------EKGNIWSVGWNAPQMSIGFGLESCFRVENLLTD 365

  Fly   205 K------LKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNK--VIRHYHGHLSAVYS 261
            :      .|.::..|..:..|..|     |: ....|..:|. ||..|:  :....:|..:..:.
Worm   366 RSFLMSSRKRNVLNHCFSADGNLV-----YM-GLRNDNVIKS-DLRMNRDHITGQLNGACNTTFV 423

  Fly   262 LALHPT-IDVLATSGRDSTARIWDMRTKAN-VHTLTGHTNTV--ASVVAQATNPQIITGSHDSTV 322
            ..|..| .:.:.|.|.||..||||.|...| :..:.||:|..  .:|........:.....|..|
Worm   424 RVLEKTRPECVVTEGFDSIIRIWDFRWPKNPMMEMHGHSNNCNRLNVFFDKEERFVFAAGSDGYV 488

  Fly   323 RLWDLAAGKSVCTL--TNHKKSV 343
            |.|.|.:|..:|::  .||...:
Worm   489 RGWSLTSGDMLCSVKTPNHSNPI 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	44/206 (21%)
		WD40	164..458	CDD:238121	43/203 (21%)
		WD40 repeat	177..212	CDD:293791	8/49 (16%)
		WD40 repeat	218..254	CDD:293791	8/37 (22%)
		WD40 repeat	259..295	CDD:293791	12/37 (32%)
		WD40 repeat	302..337	CDD:293791	8/36 (22%)
		WD40 repeat	343..378	CDD:293791	0/1 (0%)
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
F47D12.9	NP_498382.2	WD40	<369..>511	CDD:225201	36/148 (24%)
		WD40	<432..512	CDD:295369	23/80 (29%)
		WD40 repeat	465..504	CDD:293791	8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910