DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and rba-1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_492551.1	Gene:	rba-1 / 172801	WormBaseID:	WBGene00004312	Length:	412	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	87/388 - (22%)
Similarity:	145/388 - (37%)	Gaps:	84/388 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 LVTGTHTSLVRASLANSNADMSANGAIASHLQL----IPKKAPSIPKPKWH-------------- 159
            ::.||||.                |.:.:||.:    |....|.....||.
Worm    59 MIHGTHTC----------------GGVQNHLMISKFTITTDTPEFDDAKWDSEREEFGGYGEGSA 107

  Fly   160 APWKLSRVISGHLGWVRCIAVEPGNEWF--ATGAGDRVIKIWDLASG---------KLKLSLTGH 213
            |.|. :.:...|.|.|......|.|.:.  :.|..|.|. |:|....         :.:|.|.||
Worm   108 AKWD-TEIKINHPGEVHRARYMPHNPFIIASRGPSDDVY-IFDYTKHPSEPKDTKFRPQLRLKGH 170

  Fly   214 VSTVRGVAVS-TKHPYLFSCGEDRQVKCWDLEYNKVI-------RHYHGHLSAVYSLALHPTID- 269
            .....|::.| |:..:|.:.|:|..:..||:..|:.|       ..:.||.|....::.|...:
Worm   171 EGEGYGMSWSNTREGHLLTAGDDGMICHWDINANQTISGQIVPQSKFKGHSSNAEDVSFHALHNF 235

  Fly   270 VLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQII-TGSHDSTVRLWDLA-AGKS 332
            |..:.|.|....:||:|......|..|||..|..:.....:..|: |||.|.||.|||:. ..|.
Worm   236 VFGSVGDDRKLNLWDLRQSKPQLTAVGHTAEVNCITFNPFSEYILATGSVDKTVALWDMRNMRKK 300

  Fly   333 VCTLTNHKKSVRSIVLHP--SLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGV- 394
            :.||.:|...:..:...|  ...:.:|.|.|.:..|...:   :|:.|..:      ||:|:.|
Worm   301 MYTLKHHNDEIFQVSFSPHYETVLASSGSDDRVIVWDISK---IQDPSSSS------AASSDSVP 356

  Fly   395 ----LVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAEADKT 453
                .:..|..|.:..:.|.          |.:|.::.|.....|:...:..:.|:::|..:|
Worm   357 PEVIFIHAGHTGKVADFSWN----------PNRPWTICSSDEFNALQVWEVSNSLVSSEKWET 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	75/322 (23%)
		WD40	164..458	CDD:238121	74/319 (23%)
		WD40 repeat	177..212	CDD:293791	9/45 (20%)
		WD40 repeat	218..254	CDD:293791	10/43 (23%)
		WD40 repeat	259..295	CDD:293791	8/36 (22%)
		WD40 repeat	302..337	CDD:293791	12/36 (33%)
		WD40 repeat	343..378	CDD:293791	6/36 (17%)
		WD40 repeat	386..426	CDD:293791	9/44 (20%)
		WD40 repeat	433..457	CDD:293791	4/21 (19%)
rba-1	NP_492551.1	CAF1C_H4-bd	13..80	CDD:289068	7/36 (19%)
		WD40	118..>409	CDD:225201	73/310 (24%)
		WD40 repeat	123..169	CDD:293791	9/46 (20%)
		WD40	167..>398	CDD:295369	60/249 (24%)
		WD40 repeat	174..218	CDD:293791	10/43 (23%)
		WD40 repeat	225..261	CDD:293791	8/35 (23%)
		WD40 repeat	267..305	CDD:293791	13/37 (35%)
		WD40 repeat	311..364	CDD:293791	11/61 (18%)
		WD40 repeat	370..395	CDD:293791	5/34 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910