DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and snrp-40.2

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_491325.1	Gene:	snrp-40.2 / 172015	WormBaseID:	WBGene00015974	Length:	331	Species:	Caenorhabditis elegans

Alignment Length:	325	Identity:	68/325 - (20%)
Similarity:	124/325 - (38%)	Gaps:	63/325 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 ANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIW 199
            |...:||....:||:..|:..|        :.|:.||.|.:..........:.|:...|:.|.:|
Worm     7 ARNQMASQFLELPKRTSSLMAP--------TMVLQGHGGEIYTSQFSSDGSFLASAGYDQQIFLW 63

  Fly   200 DLASGKLK--LSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYS- 261
            :: .|:.:  ..|.||...:..|..:....:|.|.|.|:.|:.||:|....||::..|...|.|
Worm    64 NV-FGECENFAVLKGHKGAIMEVKFNADSSHLVSAGTDKTVRVWDMETGSCIRNFKSHTDIVNSV 127

  Fly   262 -----------------------------------------LALHPTIDVLATSGRDSTARIWDM 285
                                                     :..:...|.:...|.|:..::|||
Worm   128 DVNRRGPQMICSASDDGTVMVHDMRSKEAAKKFICKYQQTAVTFNDAADNVICGGIDNQIKVWDM 192

  Fly   286 RTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDL----AAGKSVCTLT----NHKKS 342
            ......:.|:||.:|:.|:........:::.|.|.::..||:    .|.:.|....    |.:|:
Worm   193 LRNDVRYVLSGHRDTITSLSVSHNGNFLLSNSMDCSLMSWDIRPFVPAQRLVARYQGASHNFEKN 257

  Fly   343 VRSIVLHP-SLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAAN-SEGVLVSGGDNGTMF 405
            :......| ..|:.|.::...:..|.......|..:.||...|||.|.: ::.:|:|.|.:.|:|
Worm   258 LLKCGWSPRDNYITAGSADRFVYVWNAKSRACVYKLPGHLGSVNCTALHPTQQILLSAGSDKTIF 322

Fly 406 405
Worm 323 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	61/299 (20%)
		WD40	164..458	CDD:238121	61/296 (21%)
		WD40 repeat	177..212	CDD:293791	6/36 (17%)
		WD40 repeat	218..254	CDD:293791	11/35 (31%)
		WD40 repeat	259..295	CDD:293791	8/77 (10%)
		WD40 repeat	302..337	CDD:293791	7/38 (18%)
		WD40 repeat	343..378	CDD:293791	5/35 (14%)
		WD40 repeat	386..426	CDD:293791	7/21 (33%)
		WD40 repeat	433..457	CDD:293791
snrp-40.2	NP_491325.1	WD40	31..321	CDD:238121	59/290 (20%)
		WD40 repeat	40..77	CDD:293791	6/37 (16%)
		WD40 repeat	82..118	CDD:293791	11/35 (31%)
		WD40 repeat	125..161	CDD:293791	1/35 (3%)
		WD40 repeat	166..202	CDD:293791	6/35 (17%)
		WD40 repeat	208..248	CDD:293791	7/39 (18%)
		WD40 repeat	258..282	CDD:293791	3/23 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910