DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Rack1

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_032169.1	Gene:	Rack1 / 14694	MGIID:	101849	Length:	317	Species:	Mus musculus

Alignment Length:	329	Identity:	85/329 - (25%)
Similarity:	126/329 - (38%)	Gaps:	88/329 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   164 LSRVISGHLGWVRCIAVEPG-NEWFATGAGDRVIKIWDLAS-----GKLKLSLTGHVSTVRGVAV 222
            |...:.||.|||..||..|. .:...:.:.|:.|.:|.|..     |..:.:|.||...|..|.:
Mouse     7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVI 71

  Fly   223 STKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGR-DSTARIWDMR 286
            |:          |.|                                 .|.||. |.|.|:||:.
Mouse    72 SS----------DGQ---------------------------------FALSGSWDGTLRLWDLT 93

  Fly   287 TKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLT----NHKKSVRSIV 347
            |........|||..|.||...:.|.||::||.|.|::||:..   .||..|    :|.:.|..:.
Mouse    94 TGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTL---GVCKYTVQDESHSEWVSCVR 155

  Fly   348 LHPSLYMFASASP-------DN-IKQWRCPEGKFVQNISGHTSIVNCMAANSEGVL-VSGGDNGT 403
            ..|:     |::|       |. :|.|.....|...|..|||..:|.:..:.:|.| .|||.:|.
Mouse   156 FSPN-----SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQ 215

  Fly   404 MFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRL-ITAEADKTIKVYKED-----DE 462
            ...||...|.:..         ::|....|.|:||  |.:|. :.|....:||::..:     ||
Mouse   216 AMLWDLNEGKHLY---------TLDGGDIINALCF--SPNRYWLCAATGPSIKIWDLEGKIIVDE 269

  Fly   463 ASEE 466
            ..:|
Mouse   270 LKQE 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	82/314 (26%)
		WD40	164..458	CDD:238121	82/314 (26%)
		WD40 repeat	177..212	CDD:293791	9/40 (23%)
		WD40 repeat	218..254	CDD:293791	4/35 (11%)
		WD40 repeat	259..295	CDD:293791	9/36 (25%)
		WD40 repeat	302..337	CDD:293791	13/34 (38%)
		WD40 repeat	343..378	CDD:293791	9/42 (21%)
		WD40 repeat	386..426	CDD:293791	9/40 (23%)
		WD40 repeat	433..457	CDD:293791	9/24 (38%)
Rack1	NP_032169.1	WD40	7..311	CDD:238121	85/329 (26%)
		WD 1	13..44		10/30 (33%)
		WD40 repeat	18..61	CDD:293791	10/42 (24%)
		WD 2	61..91		13/72 (18%)
		WD40 repeat	67..103	CDD:293791	13/78 (17%)
		WD 3	103..133		14/29 (48%)
		WD40 repeat	108..144	CDD:293791	15/38 (39%)
		WD 4	146..178		7/36 (19%)
		WD40 repeat	152..189	CDD:293791	8/41 (20%)
		WD 5	190..220		10/29 (34%)
		WD40 repeat	195..231	CDD:293791	10/44 (23%)
		WD 6	231..260		10/30 (33%)
		WD40 repeat	236..279	CDD:293791	12/40 (30%)
		WD 7	281..311
		WD40 repeat	286..310	CDD:293791
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910