DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP001361

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_321784.3	Gene:	AgaP_AGAP001361 / 1281821	VectorBaseID:	AGAP001361	Length:	709	Species:	Anopheles gambiae

Alignment Length:	385	Identity:	83/385 - (21%)
Similarity:	145/385 - (37%)	Gaps:	85/385 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 KYNAGARPAEKTAPLVTGTHTSLVRASLANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWK 163
            |.|.|.|...:.|.::........|            ||..|..|..|..:..|..:......|.
Mosquito     5 KNNQGGRKKMQVAFVIRDAEEKRHR------------NGVNALQLDSINGRLYSAGRDGIIRLWN 57

  Fly   164 LSRVISG---------HLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRG 219
            .::..|.         |..||..|.:..|.....:.:.|..:|:|:...|....:|..|...|:.
Mosquito    58 STQTSSSEPYIQSMEHHNDWVNDIVLCCGGRNLISASCDTTVKVWNAHKGFCMSTLRTHRDYVQA 122

  Fly   220 VAVSTKHPYLFSCGEDRQVKCWDLE-------YNKVI--RHYHGHLSAVYSLALHPTIDVLATSG 275
            :|.:.....:.|.|.|:.:..||:.       .|..:  ....|...::||||::|:..::.:..
Mosquito   123 LAYAKDREQVASAGLDKAIFLWDVNTLTALTASNNTVTTSSISGSKDSIYSLAMNPSGTIIVSGS 187

  Fly   276 RDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHK 340
            .::|.||||.||...:..|.|||..|.:::......|:::||.|..::||
Mosquito   188 TENTLRIWDPRTCNKIAKLKGHTENVKALIVSEDGTQVVSGSSDGKIKLW--------------- 237

  Fly   341 KSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGV--LVSGGDNGT 403
                                 :|.|.||     :|.||.|:..|.|:.. :||.  ::||..:..
Mosquito   238 ---------------------SIGQQRC-----IQTISVHSEGVWCLLM-TEGFSHVISGSRDRK 275

  Fly   404 MFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCF--DQSGSRLITAEAD-KTIKVYKED 460
            :...:.|...|....        .:.:|.:.:||:  ||:|....|..:| :..|::|.:
Mosquito   276 IIMTELRNPANSVLI--------CEEQAPVLSMCYNIDQTGVWATTWNSDIRCWKLHKTE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	70/319 (22%)
		WD40	164..458	CDD:238121	69/316 (22%)
		WD40 repeat	177..212	CDD:293791	7/34 (21%)
		WD40 repeat	218..254	CDD:293791	7/44 (16%)
		WD40 repeat	259..295	CDD:293791	12/35 (34%)
		WD40 repeat	302..337	CDD:293791	6/34 (18%)
		WD40 repeat	343..378	CDD:293791	5/34 (15%)
		WD40 repeat	386..426	CDD:293791	7/41 (17%)
		WD40 repeat	433..457	CDD:293791	8/26 (31%)
AgaP_AGAP001361	XP_321784.3	WD40	<25..329	CDD:225201	78/365 (21%)
		WD40	26..322	CDD:238121	76/357 (21%)
		WD40 repeat	79..115	CDD:293791	7/35 (20%)
		WD40 repeat	120..160	CDD:293791	8/39 (21%)
		WD40 repeat	172..207	CDD:293791	12/34 (35%)
		WD40 repeat	213..249	CDD:293791	12/76 (16%)
		WD40 repeat	255..290	CDD:293791	8/35 (23%)
		WD40 repeat	297..321	CDD:293791	7/23 (30%)
		DUF3337	537..705	CDD:288649
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910