DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP001414

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_321720.3	Gene:	AgaP_AGAP001414 / 1281763	VectorBaseID:	AGAP001414	Length:	509	Species:	Anopheles gambiae

Alignment Length:	320	Identity:	71/320 - (22%)
Similarity:	124/320 - (38%)	Gaps:	59/320 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 PWKLSRVIS-GHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHV--------ST 216
            |.:|:|.|. |....|.|....|..::..||:.|..|::|:..:||::..|....        ..
Mosquito   202 PTQLARQIKFGQKSHVECALFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMEQA 266

  Fly   217 VRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYH-GHLSAVYSLALHPTIDVLATSGRDSTA 280
            :..:|.|.....|.:..:|.|||.|.|...:.:|.:. .|...|..|........:.|:..|...
Mosquito   267 ILSMAFSRDSEMLATGSQDGQVKVWKLLTGQCLRRFEKAHSKGVTCLHFSRDNSQILTASFDHLI 331

  Fly   281 RIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCT---LTNHKKS 342
            |::.:::...:....|||:.|...........:::.|.|.||::|.|...:.:.|   |..| .:
Mosquito   332 RLYGLKSGKMLKEFRGHTSFVNEAAFSPDGHHVLSASSDGTVKVWSLKTTECISTFKALGTH-LA 395

  Fly   343 VRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEGVLVSGGDNGTMFFW 407
            |.|:::.|                :.||...|.|.|....|:     |.:|.:|....:|.
Mosquito   396 VNSVLILP----------------KNPEHFVVCNRSNTVVIM-----NMQGQIVRSFSSGK---- 435

  Fly   408 DWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLI-------TAEADKTIKVYKED 460
              |.|..|  ..|.:.|      .|.|..|   .|..|:       :.:.::|:.|:::|
Mosquito   436 --REGGAF--ICATISP------RGEFIYC---CGEDLVLYCFSVTSGKLERTLNVHEKD 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	70/316 (22%)
		WD40	164..458	CDD:238121	69/313 (22%)
		WD40 repeat	177..212	CDD:293791	10/34 (29%)
		WD40 repeat	218..254	CDD:293791	10/36 (28%)
		WD40 repeat	259..295	CDD:293791	5/35 (14%)
		WD40 repeat	302..337	CDD:293791	7/37 (19%)
		WD40 repeat	343..378	CDD:293791	7/34 (21%)
		WD40 repeat	386..426	CDD:293791	9/39 (23%)
		WD40 repeat	433..457	CDD:293791	5/30 (17%)
AgaP_AGAP001414	XP_321720.3	LisH	5..38	CDD:128913
		CTLH	40..90	CDD:128914
		WD40	<198..509	CDD:225201	71/320 (22%)
		WD40	205..508	CDD:238121	70/317 (22%)
		WD40 repeat	219..256	CDD:293791	10/36 (28%)
		WD40 repeat	268..305	CDD:293791	10/36 (28%)
		WD40 repeat	310..346	CDD:293791	5/35 (14%)
		WD40 repeat	353..388	CDD:293791	7/34 (21%)
		WD40 repeat	396..432	CDD:293791	12/56 (21%)
		WD40 repeat	440..477	CDD:293791	9/47 (19%)
		WD40 repeat	483..507	CDD:293791	71/320 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910