DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP002019

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_321036.4	Gene:	AgaP_AGAP002019 / 1281099	VectorBaseID:	AGAP002019	Length:	347	Species:	Anopheles gambiae

Alignment Length:	340	Identity:	92/340 - (27%)
Similarity:	160/340 - (47%)	Gaps:	35/340 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 IPKKAPSIPKP--KWHAP-------------WKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRV 195
            ||....:.|.|  ..|||             :.|...::||...|..:...|..||.|:.:.|::
Mosquito    17 IPTPIQTAPPPSQSQHAPSSQNRQSLSVKPNYTLKFTLAGHTKAVSAVKFSPNGEWLASSSADKL 81

  Fly   196 IKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVY 260
            ||||....||.:.:::||...:..||.|:....|.:..:|:.:|.|:|...|.::...||.:.|:
Mosquito    82 IKIWGAYDGKFEKTISGHKLGISDVAWSSDSRLLVTASDDKTLKIWELSSGKCLKTLKGHTNYVF 146

  Fly   261 SLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLW 325
            ....:|..:::.:...|.:.||||:||...:.||..|::.|::|........|::.|:|...|:|
Mosquito   147 CCNFNPQSNLIVSGSFDESVRIWDVRTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 211

  Fly   326 DLAAGKSVCTLTNHKKSVRSIV-LHPS-LYMFASASPDNIKQWRCPEGKFVQNISGHTSIVNCMA 388
            |.|:|:.:.||.:......|.| ..|: .|:.|:...:.:|.|...:||.::..:||.:...|:.
Mosquito   212 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHRNEKYCIF 276

  Fly   389 ANSEGV----LVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAE 449
            ||....    :|||.::..::.|:.::....|..|     |..|:     .:|.....:..|.|.
Mosquito   277 ANFSVTGGKWIVSGSEDHMVYIWNLQSKEIVQTLQ-----GHTDT-----VLCTACHPTENIIAS 331

  Fly   450 A----DKTIKVYKED 460
            |    |||||::|.|
Mosquito   332 AALENDKTIKLWKSD 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	84/319 (26%)
		WD40	164..458	CDD:238121	83/303 (27%)
		WD40 repeat	177..212	CDD:293791	11/34 (32%)
		WD40 repeat	218..254	CDD:293791	9/35 (26%)
		WD40 repeat	259..295	CDD:293791	10/35 (29%)
		WD40 repeat	302..337	CDD:293791	10/34 (29%)
		WD40 repeat	343..378	CDD:293791	9/36 (25%)
		WD40 repeat	386..426	CDD:293791	9/43 (21%)
		WD40 repeat	433..457	CDD:293791	9/27 (33%)
AgaP_AGAP002019	XP_321036.4	WD40	<47..347	CDD:225201	85/310 (27%)
		WD40	50..344	CDD:238121	83/303 (27%)
		WD40 repeat	61..98	CDD:293791	12/36 (33%)
		WD40 repeat	104..140	CDD:293791	9/35 (26%)
		WD40 repeat	145..181	CDD:293791	10/35 (29%)
		WD40 repeat	188..223	CDD:293791	10/34 (29%)
		WD40 repeat	230..266	CDD:293791	9/35 (26%)
		WD40 repeat	274..311	CDD:293791	8/36 (22%)
		WD40 repeat	317..343	CDD:293791	9/25 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920