DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP012029

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_320491.4	Gene:	AgaP_AGAP012029 / 1280633	VectorBaseID:	AGAP012029	Length:	378	Species:	Anopheles gambiae

Alignment Length:	363	Identity:	78/363 - (21%)
Similarity:	146/363 - (40%)	Gaps:	50/363 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 VLDKVAKIGEARKASGAQTPGDKTLAITDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTS 120
            ||.:..| |...|.:|.....:.|..:|  |:||.::                     :..|:..
Mosquito     5 VLQRHLK-GHRGKLTGLSFNPEGTRFVT--SSTDHSA---------------------IVWTNNE 45

  Fly   121 LVRASLANSNADM------SANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRV-----ISGHLGW 174
            .||.....::.|:      |.:|.|.|          ::.|.:....|..|.:     ..||...
Mosquito    46 QVRCMRFEAHTDVVNDVCWSPDGRIIS----------TVSKDRSVKIWVPSMLGNSDEFRGHTSN 100

  Fly   175 VRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVK 239
            ||.:..:|..:...|.:.|:.:|:|.::..:...|.|||.:.||....|.....:.|||:||.:|
Mosquito   101 VRSVDFDPTGKKLLTASDDKTVKLWKVSRKQFLSSFTGHTNWVRCARFSPNGKLIASCGDDRTLK 165

  Fly   240 CWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASV 304
            .:|....:.:..::....|...:|.||...::|.:..:...:|:|:..:..:.....:...|.|:
Mosquito   166 LFDPATGQCVHSFYDQKGAGCKVAWHPDSTLVAIALDNCRVKIFDINIRKLIQYYRIYDGPVNSL 230

  Fly   305 VAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPD-NIKQWRC 368
            ....:...:||||.|...::.||..|:.:.|||.|:..|.::.......:||:.|.| ::..|:.
Mosquito   231 DFHPSGNYLITGSDDGVTKIIDLLEGRQIFTLTGHRGPVTTVKFSKDGQLFATGSDDCHVMLWKA 295

  Fly   369 PEGKFVQNISGHTSIVNCMAANSEGVLVSGGDNGTMFF 406
            .    :.|.|...|:.....::.|....:..|...:.|
Mosquito   296 N----LDNDSAQNSLYTPEGSSCESTHPAASDQRKLSF 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	58/252 (23%)
		WD40	164..458	CDD:238121	57/249 (23%)
		WD40 repeat	177..212	CDD:293791	6/34 (18%)
		WD40 repeat	218..254	CDD:293791	9/35 (26%)
		WD40 repeat	259..295	CDD:293791	6/35 (17%)
		WD40 repeat	302..337	CDD:293791	10/34 (29%)
		WD40 repeat	343..378	CDD:293791	7/35 (20%)
		WD40 repeat	386..426	CDD:293791	3/21 (14%)
		WD40 repeat	433..457	CDD:293791
AgaP_AGAP012029	XP_320491.4	WD40	8..294	CDD:238121	69/319 (22%)
		WD40	10..312	CDD:225201	73/339 (22%)
		WD40 repeat	17..54	CDD:293791	9/59 (15%)
		WD40 repeat	60..96	CDD:293791	7/45 (16%)
		WD40 repeat	101..137	CDD:293791	8/35 (23%)
		WD40 repeat	144..179	CDD:293791	9/34 (26%)
		WD40 repeat	186..219	CDD:293791	6/32 (19%)
		WD40 repeat	227..263	CDD:293791	11/35 (31%)
		WD40 repeat	269..293	CDD:293791	5/23 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920