DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and AgaP_AGAP010318

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_320124.6	Gene:	AgaP_AGAP010318 / 1280292	VectorBaseID:	AGAP010318	Length:	305	Species:	Anopheles gambiae

Alignment Length:	303	Identity:	76/303 - (25%)
Similarity:	118/303 - (38%)	Gaps:	67/303 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 KLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWD--------------------------- 200
            |..||:.||...|.|....|......:.:.|..:.|||
Mosquito     8 KPRRVLKGHQAKVLCSNWSPDKRHIVSSSQDGKLIIWDAFTTNKEHAVTMPTTWIMGCSYAPSGN 72

  Fly   201 -LASGKLKLSLTGHVSTV------RGVAVSTKHPYLFSC---GEDRQV-------KC--WDLEYN 246
             :|.|.|...:|.:..|:      |...|.|...|:..|   ..|:|:       .|  ||:|..
Mosquito    73 LVACGGLDNKVTVYPITLEEDISSRKKTVGTHTSYMSCCIFPNSDQQILTGSGDSTCALWDVESG 137

  Fly   247 KVIRHYHGHLSAVYSLALHP--TIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQAT 309
            ::::.:|||...|.|:.|.|  |.:...:...|..|.|||||:...|.:..||.:.:.||....:
Mosquito   138 QLLQSFHGHTGDVMSIDLAPNETGNTFVSGSCDKMAFIWDMRSGHVVQSFEGHQSDINSVKFHPS 202

  Fly   310 NPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSL--------YMFASASPDNIKQW 366
            ...|.|||.|||.||:|:.|.|.|......     ||:...:.        .:||..:...:..|
Mosquito   203 GDAISTGSDDSTCRLFDMRADKEVAVFCKD-----SIIFGVNCVDFSVSGRLLFAGYNDYTVNVW 262

  Fly   367 RCPEGKFVQNISGHTSIVNCMAANSEGVLVSGGDNGTMFFWDW 409
            ...:.:.|..:.||.:.|:|:..:.:|..:|.|.      ||:
Mosquito   263 DTLKAQRVCLLYGHENKVSCLQVSPDGTALSTGS------WDY 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	76/303 (25%)
		WD40	164..458	CDD:238121	75/302 (25%)
		WD40 repeat	177..212	CDD:293791	9/62 (15%)
		WD40 repeat	218..254	CDD:293791	11/47 (23%)
		WD40 repeat	259..295	CDD:293791	13/37 (35%)
		WD40 repeat	302..337	CDD:293791	15/34 (44%)
		WD40 repeat	343..378	CDD:293791	6/42 (14%)
		WD40 repeat	386..426	CDD:293791	6/24 (25%)
		WD40 repeat	433..457	CDD:293791
AgaP_AGAP010318	XP_320124.6	WD40	<6..304	CDD:225201	76/303 (25%)
		WD40	9..305	CDD:238121	75/302 (25%)
		WD40 repeat	20..57	CDD:293791	7/36 (19%)
		WD40 repeat	63..102	CDD:293791	6/38 (16%)
		WD40 repeat	107..144	CDD:293791	8/36 (22%)
		WD40 repeat	151..188	CDD:293791	12/36 (33%)
		WD40 repeat	194..230	CDD:293791	15/35 (43%)
		WD40 repeat	238..275	CDD:293791	4/36 (11%)
		WD40 repeat	280..304	CDD:293791	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910