DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and AgaP_AGAP007739

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_317781.4	Gene:	AgaP_AGAP007739 / 1278226	VectorBaseID:	AGAP007739	Length:	504	Species:	Anopheles gambiae

Alignment Length:	334	Identity:	85/334 - (25%)
Similarity:	133/334 - (39%)	Gaps:	44/334 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 TSLVRASLANSNA---DMSANGAIASHLQL---IPKKAPSIPKPK-------------------- 157
            |.|:.:...:|.|   |||.|.|..:.|.|   |.|....:|..|
Mosquito   171 TDLLASGSGDSTARIWDMSDNPANPNQLVLRHCIQKGGTEVPSNKDVTSLDWNCDGTLLATGSYD 235

  Fly   158 -----WHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTV 217
                 |.....|:..:..|.|.:..:.......:..:...|:...|||.|:|:.....:.|.:..
Mosquito   236 GYARIWRTDGLLASTLGQHKGPIFALKWNKRGNYILSAGVDKTTIIWDAATGQCTQQFSFHSAPA 300

  Fly   218 RGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARI 282
            ..|...:...:. ||..|:.:....|..:|.|:.:.||.:.|.::...|...:||:...|.|.:|
Mosquito   301 LDVDWQSNQSFA-SCSTDQCIHVCKLGVDKPIKSFQGHTNEVNAIKWDPQGQLLASCSDDMTLKI 364

  Fly   283 WDMRTKANVHTLTGHTNTVASVVAQAT-----NPQ----IITGSHDSTVRLWDLAAGKSVCTLTN 338
            |.|:....||.|..|:..:.::....|     ||.    :.:.|.||||||||:..|..:.|||.
Mosquito   365 WSMKQDTCVHDLQAHSKEIYTIKWSPTGTGTQNPNMNLILASASFDSTVRLWDVERGVCIHTLTK 429

  Fly   339 HKKSVRSIVLHPSLYMFASASPDN-IKQWRCPEGKFVQNISGHTSIVNCMAANSEGVLV-SGGDN 401
            |.:.|.|:...|.....||.|.|. :..|....|:.|.:..|...|.. :..||.|..| :...:
Mosquito   430 HTEPVYSVAFSPDGKFLASGSFDKCVHIWSTQSGQLVHSYKGTGGIFE-VCWNSRGSKVGASASD 493

  Fly   402 GTMFFWDWR 410
            |::|..|.|
Mosquito   494 GSVFVLDLR 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	69/261 (26%)
		WD40	164..458	CDD:238121	69/258 (27%)
		WD40 repeat	177..212	CDD:293791	6/34 (18%)
		WD40 repeat	218..254	CDD:293791	7/35 (20%)
		WD40 repeat	259..295	CDD:293791	11/35 (31%)
		WD40 repeat	302..337	CDD:293791	14/43 (33%)
		WD40 repeat	343..378	CDD:293791	10/35 (29%)
		WD40 repeat	386..426	CDD:293791	8/26 (31%)
		WD40 repeat	433..457	CDD:293791
AgaP_AGAP007739	XP_317781.4	LisH	6..32	CDD:285685
		WD40	154..459	CDD:238121	72/288 (25%)
		WD40 repeat	162..206	CDD:293791	12/34 (35%)
		WD40 repeat	218..253	CDD:293791	2/34 (6%)
		WD40 repeat	258..294	CDD:293791	6/35 (17%)
		eIF2A	261..469	CDD:285825	56/208 (27%)
		WD40 repeat	301..335	CDD:293791	7/34 (21%)
		WD40 repeat	341..377	CDD:293791	11/35 (31%)
		WD40 repeat	383..428	CDD:293791	14/44 (32%)
		WD40 repeat	434..458	CDD:293791	7/23 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53955
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920