DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP005631

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_315646.3	Gene:	AgaP_AGAP005631 / 1276316	VectorBaseID:	AGAP005631	Length:	461	Species:	Anopheles gambiae

Alignment Length:	492	Identity:	364/492 - (73%)
Similarity:	404/492 - (82%)	Gaps:	43/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 MEDVQKHSVHTLIFRSLKRTHDLFVSNQGNLPEIDERLEKLRRSIKAKDGYGLVLDKVAKI---- 63
            ||:||:||||||:|||||||||.||:||..||||||.||||:.:|||:|.||||.|:.||.
Mosquito     1 MEEVQRHSVHTLVFRSLKRTHDFFVANQSLLPEIDETLEKLKYNIKARDTYGLVFDRAAKAKALA 65

  Fly    64 ---GEARKASGAQTPGDKTLAIT-----DGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTS 120
               |::.:..|.....|..||||     :|||:|..:|..:||       ||....|
Mosquito    66 AKRGDSDRIEGQHGGKDGVLAITAAGEQEGSASDGTNGQMALV-------PAATPTP-------- 115

  Fly   121 LVRASLANSNADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNE 185
                            .|.:|.:|::|||||:||||||||||||.||||||||||||:|||||||
Mosquito   116 ----------------QAASSAVQILPKKAPTIPKPKWHAPWKLCRVISGHLGWVRCVAVEPGNE 164

  Fly   186 WFATGAGDRVIKIWDLASGKLKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIR 250
            ||||||.||||||||||||||||||||||||||.:|||.:|||||||||||||||||||||||||
Mosquito   165 WFATGAADRVIKIWDLASGKLKLSLTGHVSTVRALAVSPRHPYLFSCGEDRQVKCWDLEYNKVIR 229

  Fly   251 HYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTLTGHTNTVASVVAQATNPQIIT 315
            ||||||||||:::||||||||.|:|||||||:||||||||:||||||||||||||.||.||||||
Mosquito   230 HYHGHLSAVYTMSLHPTIDVLVTAGRDSTARVWDMRTKANIHTLTGHTNTVASVVTQAANPQIIT 294

  Fly   316 GSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPSLYMFASASPDNIKQWRCPEGKFVQNISGH 380
            |||||||||||||||||:|||||||||||:||||||||||||||||||||||||||.|:||:.||
Mosquito   295 GSHDSTVRLWDLAAGKSMCTLTNHKKSVRAIVLHPSLYMFASASPDNIKQWRCPEGNFIQNLGGH 359

  Fly   381 TSIVNCMAANSEGVLVSGGDNGTMFFWDWRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRL 445
            .|||||||.|.|||||||||||||||||||||||||||||.|||||||||||||:|.||||||||
Mosquito   360 NSIVNCMAVNPEGVLVSGGDNGTMFFWDWRTGYNFQRFQAAVQPGSMDSEAGIFSMTFDQSGSRL 424

  Fly   446 ITAEADKTIKVYKEDDEASEESHPINWRPDLLKRRKF 482
            ||.|||||||:|||||||:||||||||||:::||||:
Mosquito   425 ITTEADKTIKIYKEDDEATEESHPINWRPEIIKRRKY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	266/296 (90%)
		WD40	164..458	CDD:238121	263/293 (90%)
		WD40 repeat	177..212	CDD:293791	32/34 (94%)
		WD40 repeat	218..254	CDD:293791	31/35 (89%)
		WD40 repeat	259..295	CDD:293791	28/35 (80%)
		WD40 repeat	302..337	CDD:293791	31/34 (91%)
		WD40 repeat	343..378	CDD:293791	31/34 (91%)
		WD40 repeat	386..426	CDD:293791	36/39 (92%)
		WD40 repeat	433..457	CDD:293791	20/23 (87%)
AgaP_AGAP005631	XP_315646.3	WD40	<140..437	CDD:225201	266/296 (90%)
		WD40	143..437	CDD:238121	263/293 (90%)
		WD40 repeat	156..191	CDD:293791	32/34 (94%)
		WD40 repeat	197..233	CDD:293791	31/35 (89%)
		WD40 repeat	238..274	CDD:293791	28/35 (80%)
		WD40 repeat	281..316	CDD:293791	31/34 (91%)
		WD40 repeat	322..357	CDD:293791	31/34 (91%)
		WD40 repeat	363..401	CDD:293791	35/37 (95%)
		WD40 repeat	412..436	CDD:293791	20/23 (87%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	142	1.000	Domainoid score	I9629
eggNOG	1	0.900	-	-		E1_KOG0285
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2004
Inparanoid	1	1.050	743	1.000	Inparanoid score	I1665
OMA	1	1.010	-	-		QHG53955
OrthoDB	1	1.010	-	-		D1157847at2759
OrthoFinder	1	1.000	-	-		FOG0004264
OrthoInspector	1	1.000	-	-		oto107776
Panther	1	1.100	-	-	LDO	PTHR19923
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3002
TreeFam	1	0.960	-	-
	13	12.940