DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango4 and CIAO1_ANOGA

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_310648.3	Gene:	CIAO1_ANOGA / 1271794	VectorBaseID:	AGAP000444	Length:	341	Species:	Anopheles gambiae

Alignment Length:	295	Identity:	76/295 - (25%)
Similarity:	131/295 - (44%)	Gaps:	53/295 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 WKLSRVIS-GHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLT--GHVSTVRGVAVS 223
            |....|:: ||...:|.:|......:.|:.:.|..:.:||..||:.:.:.|  ||.:.|:.|..|
Mosquito    49 WVAQTVLTDGHTRTIRELAWSCCGHYLASASFDTTVAVWDKKSGEFECNATLEGHDNEVKSVTWS 113

  Fly   224 TKHPYLFSCGEDRQVKCWDL--------EYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTA 280
            .....|.:|..|:.|..|::        || :.:...:||...|..:..||..|:||::..|:|.
Mosquito   114 RSGNLLATCSRDKSVWIWEIHHAPDQEDEY-ECVAVLNGHTQDVKKVCWHPQEDLLASASYDNTI 177

  Fly   281 RI---------WDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLW-----DLAAG- 330
            |:         |:|     :..|..|::||.|:...||..::.:.|.|:||::|     |.|.|
Mosquito   178 RMYRQDLADSEWEM-----LEPLESHSSTVWSISFDATGQRLASCSEDTTVKVWQQYGPDNALGI 237

  Fly   331 ---------KSVCTLTN-HKKSVRSIVLHPSLYMFASA-SPDNIKQWR--------CPEGKFVQN 376
                     |.||||:. |.:||..|.......:.|:| ..|.::.:|        .|..:.|..
Mosquito   238 PCPDRGTIWKCVCTLSGYHSRSVYDIDWCKQTGLLATACGDDTVRIFREASDSDRNEPTFELVVT 302

  Fly   377 ISGHTSIVNCMA--ANSEGVLVSGGDNGTMFFWDW 409
            :..|:...|.:|  ....|:|::..|:|.:..|.:
Mosquito   303 VEAHSQDANKVAWHPTVPGLLLTASDDGEIKLWQY 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	76/295 (26%)
		WD40	164..458	CDD:238121	75/293 (26%)
		WD40 repeat	177..212	CDD:293791	8/36 (22%)
		WD40 repeat	218..254	CDD:293791	9/43 (21%)
		WD40 repeat	259..295	CDD:293791	11/44 (25%)
		WD40 repeat	302..337	CDD:293791	15/49 (31%)
		WD40 repeat	343..378	CDD:293791	8/43 (19%)
		WD40 repeat	386..426	CDD:293791	6/26 (23%)
		WD40 repeat	433..457	CDD:293791
CIAO1_ANOGA	XP_310648.3	WD40	<2..335	CDD:225201	75/291 (26%)
		WD40	6..336	CDD:238121	75/292 (26%)
		WD40 repeat	17..58	CDD:293791	2/8 (25%)
		WD40 repeat	64..102	CDD:293791	9/37 (24%)
		WD40 repeat	107..150	CDD:293791	10/43 (23%)
		WD40 repeat	157..196	CDD:293791	10/43 (23%)
		WD40 repeat	202..253	CDD:293791	16/50 (32%)
		WD40 repeat	260..304	CDD:293791	8/43 (19%)
		WD40 repeat	311..335	CDD:293791	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910