DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP007125

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_308636.2	Gene:	AgaP_AGAP007125 / 1269981	VectorBaseID:	AGAP007125	Length:	458	Species:	Anopheles gambiae

Alignment Length:	366	Identity:	79/366 - (21%)
Similarity:	137/366 - (37%)	Gaps:	69/366 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 LVLDKVAKIGEARKASGAQTPGDKTLAITDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGT-- 117
            :::.|:|.:....|.| |....|....::|....:                  |...|::|..
Mosquito   113 VIVMKMANLTRTSKQS-ADGESDDDEEVSDSEDVN------------------EDQTPILTSVMI 158

  Fly   118 -HTSLV---RASLANSN---ADMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSR--------- 166
             |...|   |.|...|:   |..|..|.:  |:..|.::..:|...:....::.::
Mosquito   159 KHPGCVNRLRVSTFGSSQYVASWSEMGKV--HIYNINEQLAAIDDSRARKTYQQNKTGDGVKPDF 221

  Fly   167 VISGH------LGWVRCIAVEPGNEWFATGAGDRVIKIW---DLASGKL-KLSLTGHVSTVRGVA 221
            ..|||      :.|  |...   ....|||...|.|.||   |..:..: :..|.||..:|..:.
Mosquito   222 TFSGHQKEGFAIDW--CPTT---RGMLATGDCRRDIHIWRPNDKGAWIVDQRPLVGHTDSVEDIQ 281

  Fly   222 VSTKHP-YLFSCGEDRQVKCWDLEYNK----VIRHYHGHLSAVYSLALHPTIDVLATSGRDSTAR 281
            .|.... .|.||..|:.::.||.....    ::...:.|.|.|..::.:....::|:.|.|...:
Mosquito   282 WSPNEANVLASCSVDKSIRIWDCRAAPAKACMLTAENAHESDVNVISWNRNEPLIASGGDDGVLQ 346

  Fly   282 IWDMR---TKANVHTLTGHTNTVASVVAQATNPQII-TGSHDSTVRLWDLAAGKSVCTLTNHKKS 342
            |||:|   :|..|.|...||:.:.:|........|: :|..|..:.||||:..|......|...:
Mosquito   347 IWDLRQFQSKTPVATFKHHTDHITTVEWHPKESTILASGGDDDQIALWDLSVEKDDGDDANDDPN 411

  Fly   343 VRSIVLHPSLYMFASASPDNIKQ--WRCPEGKFVQNISGHT 381
            ::.:   |...:|.......||:  |. |:.|.|...:.|:
Mosquito   412 LKDL---PPQLLFIHQGQSEIKELHWH-PQLKGVILSTAHS 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	58/251 (23%)
		WD40	164..458	CDD:238121	58/248 (23%)
		WD40 repeat	177..212	CDD:293791	10/38 (26%)
		WD40 repeat	218..254	CDD:293791	7/40 (18%)
		WD40 repeat	259..295	CDD:293791	11/38 (29%)
		WD40 repeat	302..337	CDD:293791	9/35 (26%)
		WD40 repeat	343..378	CDD:293791	8/36 (22%)
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
AgaP_AGAP007125	XP_308636.2	CAF1C_H4-bd	54..121	CDD:289068	2/7 (29%)
		WD40	<147..>449	CDD:225201	72/313 (23%)
		WD40	160..>400	CDD:295369	58/246 (24%)
		WD40 repeat	231..272	CDD:293791	11/45 (24%)
		WD40 repeat	277..317	CDD:293791	8/39 (21%)
		WD40 repeat	325..362	CDD:293791	9/36 (25%)
		WD40 repeat	369..421	CDD:293791	11/54 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910