DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and AgaP_AGAP012479

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_306900.4	Gene:	AgaP_AGAP012479 / 1268343	VectorBaseID:	AGAP012479	Length:	321	Species:	Anopheles gambiae

Alignment Length:	351	Identity:	70/351 - (19%)
Similarity:	127/351 - (36%)	Gaps:	70/351 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VHTLIFRSL-----KRTHDLFVSNQGNLPEIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKAS 70
            ::.|||.|:     |.....|::|.|.:|:...|.:...:.|.....:.:       :|:.....
Mosquito     1 MNILIFFSIEDPLEKSAAIGFINNFGQIPKQLFRKQHPAKRITTTKQFSI-------LGDVSPLH 58

  Fly    71 GAQTPGDKTLAI---------------TDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTS 120
            ..|||...|.||               :.....:.....|.::.|.......|:...|:..::..
Mosquito    59 PPQTPIGVTPAINYEKIFFYHLNNLKSSQQPIKELKGPVGQIIHYEKQILCVEQNKMLIPSSYNR 123

  Fly   121 LVRASLANSNADMSA--NGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPG 183
            .|....|:.:..:..  :|.|                   |..|: :..|.|.:....|    |.
Mosquito   124 YVGWGFADHSLRIGCYDSGRI-------------------HQVWE-NVDICGEIHTCTC----PS 164

  Fly   184 NEWFATGAGDRVIKIWDLASGKLKLSLT----GHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLE 244
            .:.........|:.::.:.:...|:||.    ||:..|..:..||.:..:.|...|:....|||.
Mosquito   165 AKLLIFAGTSSVLSVYHMDTNMKKISLKQTLYGHIDAVTALTSSTAYNIIISGSRDQTAIIWDLA 229

  Fly   245 YNKVIRHYHGHLSAVYSLALHP-TIDVLATSGRDSTARIWDMR--TKANVHTLTGHTNTVASVVA 306
            .....|...||:.||.:::::. |.|:...||  :...||.:.  ..|.|:|..|.::.:..::.
Mosquito   230 RMTYTRQLIGHVGAVTAISINELTGDIATCSG--TWLYIWSINGLPLAVVNTSMGSSDRMQQILC 292

  Fly   307 QA--------TNPQIITGSHDSTVRL 324
            ..        ||..|||||.|..:|:
Mosquito   293 VTFSYIREWDTNNVIITGSTDGRIRV 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	43/179 (24%)
		WD40	164..458	CDD:238121	42/176 (24%)
		WD40 repeat	177..212	CDD:293791	6/38 (16%)
		WD40 repeat	218..254	CDD:293791	8/35 (23%)
		WD40 repeat	259..295	CDD:293791	10/38 (26%)
		WD40 repeat	302..337	CDD:293791	9/31 (29%)
		WD40 repeat	343..378	CDD:293791
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
AgaP_AGAP012479	XP_306900.4	Beach	<8..40	CDD:299188	7/31 (23%)
		WD40	<131..318	CDD:295369	45/212 (21%)
		WD40 repeat	158..197	CDD:293791	6/42 (14%)
		WD40	<159..318	CDD:225201	39/164 (24%)
		WD40 repeat	202..238	CDD:293791	9/35 (26%)
		WD40 repeat	245..283	CDD:293791	9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910