DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and Pwp2

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_083822.1	Gene:	Pwp2 / 110816	MGIID:	1341200	Length:	919	Species:	Mus musculus

Alignment Length:	532	Identity:	121/532 - (22%)
Similarity:	193/532 - (36%)	Gaps:	93/532 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KHSVHTLIFRSLKRTHDLFVSNQGNLPEIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGA 72
            |.|||::.|....|.   ||..:||:.::.....| :|...|     .|||| ...|
Mouse    96 KGSVHSVSFSPDGRK---FVVTKGNIAQMYHAPGK-KREFNA-----FVLDK-TYFG-------- 142

  Fly    73 QTPGDKTLAI--TDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNA---- 131
              |.|:|..|  ||.|..... |:..:..:..||...:.........|...:.|....||:
Mouse   143 --PYDETTCIDWTDDSKCFVV-GSKDMSTWVFGAERWDNLIYYALSGHKDAIVACFFESNSLDLY 204

  Fly   132 DMSANGAIASHLQLIPKKAPSIPKPK-WHA----------------------------PWKLSRV 167
            .:|.:||:.......|.:...:..|: |.|                            |.:..||
Mouse   205 SLSQDGALCVWQCDTPPEGLRLKAPRGWKADILQREKEEEEEDEEEGDRETTIRGKTTPAEQERV 269

  Fly   168 --------------ISGHLGWVRCIAVEPGNEWFATGAGDRVIKIWDLASGKLKLSLTGHVSTVR 218
                          ..|....:...|.........||....:..:.:|....|..||:.....|.
Mouse   270 GKVKYSRLAKYFLNKEGDFNNLTSAAYHKKTHLLVTGFASGIFHLHELPEFNLIHSLSISDQRVA 334

  Fly   219 GVAVSTKHPYL-FSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARI 282
            .||:::...:: |.|....|:..|:.:....:....||.:::.:||..|....:.|.|.|...::
Mouse   335 SVAINSSGDWIAFGCSGMGQLLVWEWQSESYVLKQQGHFNSMVALAYSPDGQYIVTGGDDGKVKV 399

  Fly   283 WDMRTKANVHTLTGHTNTVASVVAQATNPQIITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIV 347
            |:..:.....|||.|::.|..|....|...|:|.|.|.|||.:||...::..|.|:.:.:..|.|
Mouse   400 WNTLSGFCFVTLTEHSSGVTGVTFTTTGHVIVTSSLDGTVRAFDLHRYRNFRTFTSPRPTQFSCV 464

  Fly   348 LHPSLYMFASASPDN---IKQWRCPEGKFVQNISGHTSIVNCMAAN-SEGVLVSGGDNGTMFFWD 408
            ...|.....||...:   |..|....|:.:..:|||...|:.:..| .:.:|.|...:.|:..||
Mouse   465 AVDSSGEIVSAGAQDSFEIFVWSMQTGRLLDVLSGHEGPVSGLCFNPMKSILASASWDKTVRLWD 529

  Fly   409 ----WRTGYNFQRFQAPVQPGSMDSEAGIFAMCFDQSGSRLITAEADKTIKVYKEDDEASEESHP 469
                |||....          ::.|:|  .|:.|...|:.|..|..:..|..:  |.|.:.:...
Mouse   530 MFDSWRTKETL----------TLTSDA--LAVTFRPDGAELAVATLNSQITFW--DPENAVQVGS 580

  Fly   470 INWRPDLLKRRK 481
            |..|.||...||
Mouse   581 IEGRHDLKTGRK 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	74/319 (23%)
		WD40	164..458	CDD:238121	73/316 (23%)
		WD40 repeat	177..212	CDD:293791	7/34 (21%)
		WD40 repeat	218..254	CDD:293791	6/36 (17%)
		WD40 repeat	259..295	CDD:293791	8/35 (23%)
		WD40 repeat	302..337	CDD:293791	12/34 (35%)
		WD40 repeat	343..378	CDD:293791	8/37 (22%)
		WD40 repeat	386..426	CDD:293791	9/44 (20%)
		WD40 repeat	433..457	CDD:293791	6/23 (26%)
Pwp2	NP_083822.1	WD 1	12..50
		WD40 repeat	17..51	CDD:293791
		WD40	20..401	CDD:295369	65/325 (20%)
		WD 2	53..93
		WD40	58..469	CDD:225201	86/393 (22%)
		WD40 repeat	59..93	CDD:293791
		WD 3	94..132		12/39 (31%)
		WD40 repeat	101..142	CDD:293791	13/50 (26%)
		WD 4	142..181		11/49 (22%)
		WD40 repeat	148..186	CDD:293791	7/38 (18%)
		WD 5	186..225		8/38 (21%)
		WD40 repeat	191..258	CDD:293791	10/66 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	238..266		1/27 (4%)
		WD40	<277..643	CDD:225201	79/330 (24%)
		WD 6	286..325		6/38 (16%)
		WD40 repeat	292..327	CDD:293791	6/34 (18%)
		WD40	322..629	CDD:238121	74/285 (26%)
		WD 7	328..368		7/39 (18%)
		WD40 repeat	333..371	CDD:293791	7/37 (19%)
		WD 8	371..410		9/38 (24%)
		WD40 repeat	377..413	CDD:293791	9/35 (26%)
		WD 9	413..452		13/38 (34%)
		WD40 repeat	418..454	CDD:293791	13/35 (37%)
		WD 10	456..498		8/41 (20%)
		WD40 repeat	462..498	CDD:293791	8/35 (23%)
		WD 11	499..538		12/38 (32%)
		WD40 repeat	504..540	CDD:293791	10/35 (29%)
		WD 12	541..580		10/42 (24%)
		WD40 repeat	546..601	CDD:293791	15/51 (29%)
		WD 13	603..642
		WD40 repeat	608..632	CDD:293791
		WD 14	700..740
		Utp12	771..873	CDD:281932
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	885..919
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910