DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and wdfy3

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	XP_002937925.2	Gene:	wdfy3 / 100496744	XenbaseID:	XB-GENE-1005846	Length:	3509	Species:	Xenopus tropicalis

Alignment Length:	339	Identity:	72/339 - (21%)
Similarity:	124/339 - (36%)	Gaps:	62/339 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 HDLFVSNQGNLPEIDERLEKLRRSIKAKDGYGLVLDKVAKIGEARKASGAQTPGDKT-LAITDGS 86
            |.||...|.::..|::.| |...:|...:.:|.:..::.|.....|....:..||.| :::..|:
Frog  2914 HHLFYEGQVDIYNINDPL-KETATIGFINNFGQIPKQLFKKPHPPKRVRGRINGDLTSMSLPVGT 2977

  Fly    87 ATD-------------------AASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNAD 132
            |.|                   .....|.:|..:.|....|:...|:......    :.|...||
Frog  2978 ACDKIFFHHLDNLRPSLAPVKELKEPVGQIVCTDKGILAVEQNKVLIPPAWNK----TFAWGYAD 3038

  Fly   133 MSAN-GAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRVI 196
            :|.. |...|...::..:..|    :|              |.:.| .:.|..:...||....||
Frog  3039 LSCRLGTYESDKAVVVYECLS----EW--------------GQILC-TICPNPKMVITGGTSTVI 3084

  Fly   197 KIWDLASGK-------LKLSLTGHVSTVRGVAVSTKHPYLFSCGEDRQVKCWDLEYNKVIRHYHG 254
            .:|:..:.|       ||.:|.||..||..:..|..:..:.|...||....|||.....:....|
Frog  3085 CVWEAGTSKEKAKSLNLKQALIGHTDTVTCLTASLAYHIVVSGSRDRTCIIWDLNKLAFVTQLRG 3149

  Fly   255 HLSAVYSLALHP-TIDVLATSGRDSTARIWDMRTK--ANVHTLTGHTNTVASVVAQATNP----- 311
            |.:.|.:|.::. |.|:::.:|  :...:|.:...  .:|:|..|.:..:........|.
Frog  3150 HRAPVSALCINELTGDIVSCAG--TYIHVWSINGNPIVSVNTFIGRSQQILCCCVSEMNEWDTQN 3212

  Fly   312 QIITGSHDSTVRLW 325
            .|:||..|..||.|
Frog  3213 VIVTGHSDGVVRFW 3226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	42/180 (23%)
		WD40	164..458	CDD:238121	42/177 (24%)
		WD40 repeat	177..212	CDD:293791	11/41 (27%)
		WD40 repeat	218..254	CDD:293791	7/35 (20%)
		WD40 repeat	259..295	CDD:293791	8/38 (21%)
		WD40 repeat	302..337	CDD:293791	8/29 (28%)
		WD40 repeat	343..378	CDD:293791
		WD40 repeat	386..426	CDD:293791
		WD40 repeat	433..457	CDD:293791
wdfy3	XP_002937925.2	PH_BEACH	2516..2639	CDD:275391
		Beach	2678..2958	CDD:366934	10/44 (23%)
		WD40	3066..>3228	CDD:392136	41/164 (25%)
		WD40 repeat	3066..3107	CDD:293791	11/41 (27%)
		WD40 repeat	3113..3149	CDD:293791	7/35 (20%)
		WD40 repeat	3154..3191	CDD:293791	8/38 (21%)
		WD40 repeat	3198..3233	CDD:293791	8/29 (28%)
		FYVE_WDFY3	3433..3497	CDD:277259
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910