DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango4 and taf5

DIOPT Version :9

Sequence 1:	NP_572778.1	Gene:	Tango4 / 32168	FlyBaseID:	FBgn0030365	Length:	482	Species:	Drosophila melanogaster
Sequence 2:	NP_001135586.1	Gene:	taf5 / 100216139	XenbaseID:	XB-GENE-1004611	Length:	777	Species:	Xenopus tropicalis

Alignment Length:	444	Identity:	102/444 - (22%)
Similarity:	160/444 - (36%)	Gaps:	78/444 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VQKHSVHTLIFRSLKRTHDLFVSNQGNLPEIDERLEKLRRSIKAKDGYGLVLDKVAKI---GEAR 67
            ||:| ::..||..:.|:.....:..|:|..     |..|.:.|||..:||:.:...::   .|..
Frog   310 VQEH-LYIDIFDGMPRSKQQIDAMVGSLSG-----EAKREANKAKIFFGLLKEPEIEVPLDDEDE 368

  Fly    68 KASGAQTPGDKTLAITDGSATDAASGAGSLVKYNAGARPAEKTAPLVTGTHTSLVRASLANSNA- 131
            :....:....|.....|        ..||..|......|.:...||          ..|.:|:.
Frog   369 EVENEEGKPKKKKPKKD--------NVGSKSKKQDPNAPPQNRIPL----------PELKDSDKL 415

  Fly   132 -DMSANGAIASHLQLIPKKAPSIPKPKWHAPWKLSRVISGHLGWVRCIAVEPGNEWFATGAGDRV 195
             .:......|..::|.....|||         .....::.:.| :..:.|...:...|.|..|..
Frog   416 DKIMIMKETAKRVRLGQDSLPSI---------CFYTFLNAYQG-LTAVDVTDDSSLIAGGFADST 470

  Fly   196 IKIWDLASGKLK-------LS------------------------LTGHVSTVRGVAVSTKHPYL 229
            :::|.|...||:       ||                        |.||...|...:.|....||
Frog   471 VRVWSLTPKKLRSVKSASDLSIIDKESDDVLERIMDEKSSSEMKVLYGHSGPVYATSFSPDRNYL 535

  Fly   230 FSCGEDRQVKCWDLEYNKVIRHYHGHLSAVYSLALHPTIDVLATSGRDSTARIWDMRTKANVHTL 294
            .|..||..::.|.|:....:..|.||...|:.....|......:.|.|..||:|.......:...
Frog   536 LSSSEDGTIRLWSLQTFTCLVAYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF 600

  Fly   295 TGHTNTVASVVAQATNPQ---IITGSHDSTVRLWDLAAGKSVCTLTNHKKSVRSIVLHPS-LYMF 355
            .||   :|.|:....:|.   |.|||.|.||||||:..|..|...|.||..:.|:...|: .::.
Frog   601 AGH---LADVICTRFHPNSNYIATGSTDRTVRLWDVLNGNCVRIFTGHKGPIHSLAFTPNGKFLA 662

  Fly   356 ASASPDNIKQWRCPEGKFVQNISGHTSIVNCMAANSEG-VLVSGGDNGTMFFWD 408
            ..||...:..|....|..|..:.|||:.|..:..:.:| :|.|...:.|:..||
Frog   663 TGASDGRVLLWDIGHGLMVGELKGHTNTVYALRFSRDGEILSSVSMDNTVRLWD 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango4	NP_572778.1	WD40	<161..458	CDD:225201	71/284 (25%)
		WD40	164..458	CDD:238121	71/281 (25%)
		WD40 repeat	177..212	CDD:293791	11/65 (17%)
		WD40 repeat	218..254	CDD:293791	9/35 (26%)
		WD40 repeat	259..295	CDD:293791	7/35 (20%)
		WD40 repeat	302..337	CDD:293791	16/37 (43%)
		WD40 repeat	343..378	CDD:293791	7/35 (20%)
		WD40 repeat	386..426	CDD:293791	6/24 (25%)
		WD40 repeat	433..457	CDD:293791
taf5	NP_001135586.1	TAF5_NTD2	188..320	CDD:176269	4/10 (40%)
		WD40	<426..716	CDD:225201	73/302 (24%)
		WD40	449..719	CDD:238121	71/272 (26%)
		WD40 repeat	450..507	CDD:293791	10/56 (18%)
		WD40 repeat	524..560	CDD:293791	9/35 (26%)
		WD40 repeat	565..601	CDD:293791	7/35 (20%)
		WD40 repeat	608..643	CDD:293791	14/34 (41%)
		WD40 repeat	649..685	CDD:293791	7/35 (20%)
		WD40 repeat	691..737	CDD:293791	7/26 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910