DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1492 and ECM38

DIOPT Version :9

Sequence 1:	NP_001303553.1	Gene:	CG1492 / 32164	FlyBaseID:	FBgn0030361	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_013402.1	Gene:	ECM38 / 851006	SGDID:	S000004290	Length:	660	Species:	Saccharomyces cerevisiae

Alignment Length:	649	Identity:	181/649 - (27%)
Similarity:	286/649 - (44%)	Gaps:	126/649 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 VILVAVYIYRYPDGNAGKKKASRRPPNPE-DPLP--PSNSP--------LHRFSRAAICSDSDVC 69
            |.::|.|:.:..|.:.|.|...    |.: ||||  ||.:|        ||    .||.||.:||
Yeast    61 VDIIAEYLKKDDDDDGGDKDHH----NIDIDPLPRRPSLTPDRQLLKVGLH----GAISSDLEVC 117

  Fly    70 SQLA-KKVLEN--GGSAVDGALAALICNGLIGMQSMGIGGGMVMNVYVAKENKSY-SILAREMAP 130
            |.|. .:||..  |.:|.|.|:...:|.|::...:.|||||..: |:..|:::.: ||..||.||
Yeast   118 SNLTINEVLLKFPGSNAADAAVTQALCKGMVNFFNSGIGGGGYV-VFSGKDDEDHLSIDFREKAP 181

  Fly   131 LALRADNFSSFRDEQDF---------KRSGWSIAVPAELAG-YAVAHQR-FGRLKWKDLVLPTLE 184
            :           |...|         |..|.::.||.||.| |.:..:| .|::.|:||:.|..:
Yeast   182 M-----------DSHKFMFENCSLCSKIGGLAVGVPGELMGLYRLFKERGSGQVDWRDLIEPVAK 235

  Fly   185 LCRRGYRLYKHQYDALILNQDMIRADSGLRRMFIDPDTGRFWPLGHLIRPAAQLCNTYDRLANEG 249
            |...|:::.:.....|.|.:|:.        :.:..|    |        :..|.:|:|.:..||
Yeast   236 LGSVGWQIGEALGATLELYEDVF--------LTLKED----W--------SFVLNSTHDGVLKEG 280

  Fly   250 PLSFYRGSIADDLLADLKDAGSA---------ITKEDLNQAHAKLSSAI-VMPLDEYDLHLTPP- 303
              .:.:.....::|.:|...||.         |.|..::.. ||.:..: :..:..||:|:|.|
Yeast   281 --DWIKRPALSNMLMELAKNGSVAPFYDPDHWIAKSMIDTV-AKYNGIMNLQDVSSYDVHVTKPL 342

  Fly   304 -----------------------PGSGHVLGFIMNILKEFRAEFSRAGTMSPRQIHLMVEAMKFG 345
                                   ..||..|...:.|:..|:.:  ..|.......:.::|:||:.
Yeast   343 SMKIRKGANFIPDNDMTVLTSSGSSSGAALLAALRIMDNFQNQ--EGGDYEKETTYHLLESMKWM 405

  Fly   346 FVKRWQLDESAS-------EELLSNLTSHELAKSVAR--QINHTHTFNRPEFYGASPGIQIRDEH 401
            ...|.:|.:...       ||:|....:.:..||:.|  |..:..|......|  .|...|.:.|
Yeast   406 ASARSRLGDFEGEALPKHIEEVLDPEWALKAVKSIKRNSQDGNFKTLENWTLY--DPAYDINNPH 468

  Fly   402 GTAHTSVL--HGNDAVSVTSSINFYFGSGRTGRRTGVIFNNAMSDFSIEQLKNYFDL-PFVPGTN 463
            ||||.|::  ||| |||:|::||..|||.....:|||||||.|.||:.....|.|:| |.:  .|
Yeast   469 GTAHFSIVDSHGN-AVSLTTTINLLFGSLVHDPKTGVIFNNEMDDFAQFNKSNSFELAPSI--YN 530

  Fly   464 GVAPAARPMSSMCPVIVTERATGNVRLVVGAAGGTKIISALSPLLVRILWQEASIKAAIDASRIH 528
            ...|..||:||..|.||... .|...|||||:||::|.:::...:||..|....|...|...|||
Yeast   531 FPEPGKRPLSSTAPTIVLSE-LGIPDLVVGASGGSRITTSVLQTIVRTYWYNMPILETIAYPRIH 594

  Fly   529 HQMLPNVLLYEY--GLRQSYVDSLAERGHRCERYENRGSVICGIAQANDTIWVNSDFRKPGGVS 590
            ||:||:.:..|.  .:.::.:.:|.|.|:..:....: ||:..|..........||:.:..|:|
Yeast   595 HQLLPDRIELESFPMIGKAVLSTLKEMGYTMKEVFPK-SVVNAIRNVRGEWHAVSDYWRKRGIS 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1492	NP_001303553.1	G_glu_transpept	76..587	CDD:279371	155/572 (27%)
ECM38	NP_013402.1	G_glu_transpept	101..652	CDD:418549	165/598 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	227	1.000	Domainoid score	I423
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	227	1.000	Inparanoid score	I741
Isobase	1	0.950	-	0	Normalized mean entropy	S1876
OMA	1	1.010	-	-		QHG58031
OrthoFinder	1	1.000	-	-		FOG0000229
OrthoInspector	1	1.000	-	-		otm46510
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X210
TreeFam	1	0.960	-	-
	11	10.880