DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1492 and GGT7

DIOPT Version :9

Sequence 1:	NP_001303553.1	Gene:	CG1492 / 32164	FlyBaseID:	FBgn0030361	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_821158.2	Gene:	GGT7 / 2686	HGNCID:	4259	Length:	662	Species:	Homo sapiens

Alignment Length:	555	Identity:	157/555 - (28%)
Similarity:	252/555 - (45%)	Gaps:	62/555 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 FSRAAICSDSDVCSQLAKKVLENGGSAVDGALAALICNGLIGMQSMGIGGGMVMNVYVAKENKSY 121
            |.:.|:.:|:..|:.|..:||...||:||.|:||.:|.|::...|.|:|||.||.|:..:.|:|:
Human   137 FQQGAVVTDAARCTSLGIEVLSKQGSSVDAAVAAALCLGIVAPHSSGLGGGGVMLVHDIRRNESH 201

  Fly   122 SILAREMAPLALRADNFSSFRDEQDFKRS-----GWSIAVPAELAGYAVAHQRFGRLKWKDLVLP 181
            .|..||.||.|||         |:..:||     |..:.||..:.|...|||.:|||.|..::..
Human   202 LIDFRESAPGALR---------EETLQRSWETKPGLLVGVPGMVKGLHEAHQLYGRLPWSQVLAF 257

  Fly   182 TLELCRRGYRLYKHQYDALILNQDMIRADSGLRRMFIDPDTGRFWPL-GHLI-RPAAQLCNTYDR 244
            ...:.:.|:.: .|.....:..|.........|..|:  .:|| .|| |.|: ||  .|....|.
Human   258 AAAVAQDGFNV-THDLARALAEQLPPNMSERFRETFL--PSGR-PPLPGSLLHRP--DLAEVLDV 316

  Fly   245 LANEGPLSFYR-GSIADDLLADLKDAGSAITKEDLNQAHAKLSSAIVMPLDEYDLHLT---PPPG 305
            |...||.:||. |::..:::|:.:.||..||:||.:...|.:...:   ...|..||.   |||.
Human   317 LGTSGPAAFYAGGNLTLEMVAEAQHAGGVITEEDFSNYSALVEKPV---CGVYRGHLVLSPPPPH 378

  Fly   306 SGHVLGFIMNILKEFRAEFSRAGTMSPRQ-IHLMVEAMKFGFVKRWQLD----ESASEELLSNLT 365
            :|..|...:|||:    .|:....:|..| :|.:.|.:|.......:|.    :|...|.:.::.
Human   379 TGPALISALNILE----GFNLTSLVSREQALHWVAETLKIALALASRLGDPVYDSTITESMDDML 439

  Fly   366 SHELAKSVARQINHTHTFNRP-----EFYGASPGIQIRDEHGTAHTSVLHGND--AVSVTSSINF 423
            |...|..:...||.:.....|     |..||....|:          ::.|.|  .|::.||:|.
Human   440 SKVEAAYLRGHINDSQAAPAPLLPVYELDGAPTAAQV----------LIMGPDDFIVAMVSSLNQ 494

  Fly   424 YFGSGRTGRRTGVIFNNAMSDFSIEQLKNYFDLPFVPGTNGVAPAARPMSSMCPVIV--TERATG 486
            .||||.. ..:|::.|:.|.|||..........|.:  .|.|.|..||:|.:.|.:|  .|...|
Human   495 PFGSGLI-TPSGILLNSQMLDFSWPNRTANHSAPSL--ENSVQPGKRPLSFLLPTVVRPAEGLCG 556

  Fly   487 NVRLVVGAAGGTKIISALSPLLVRILWQEASIKAAIDASRIHHQMLPNVLLYEYGLRQSYVDSLA 551
            .. |.:||.|..:.:|.|:.:|:.:|....::..::...|:|..:..|:|..:....:..::.|.
Human   557 TY-LALGANGAARGLSGLTQVLLNVLTLNRNLSDSLARGRLHPDLQSNLLQVDSEFTEEEIEFLE 620

  Fly   552 ERGHRCERYENRGSVICGIAQANDTIWVNSDFRKP 586
            .|||..|:.:.. |.:.|..:.|:.|....|.|.|
Human   621 ARGHHVEKVDVL-SWVHGSRRTNNFIIAVKDPRSP 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1492	NP_001303553.1	G_glu_transpept	76..587	CDD:279371	152/536 (28%)
GGT7	NP_821158.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..90
GGT7	NP_821158.2	G_glu_transpept	155..654	CDD:307247	151/535 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0405
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419292at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11686
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920