DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and Csmd1

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_036010291.1	Gene:	Csmd1 / 94109	MGIID:	2137383	Length:	3600	Species:	Mus musculus

Alignment Length:	1060	Identity:	262/1060 - (24%)
Similarity:	395/1060 - (37%)	Gaps:	275/1060 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 PPAVPLNAKVRTITVDSQIAE-AHYECDAGYELFGPSAVKC--DRRTGWDRDLPFCGVNVAYRKP 121
            ||||| .|.:.|...|.:|.: ..|:|..||.|.|...:.|  ..:..:....|.|....    |
Mouse  2297 PPAVP-QADLLTEDEDFEIGDFVKYQCHPGYTLLGSDTLTCKLSSQLLFQGSPPTCEAQC----P 2356

  Fly   122 VNQSSYTRSG-------PASYAN--------------------DGKPGNKNPDGQECSETQKEPS 159
            .|:.....||       |.:|.|                    |.....|..|..|..:.....|
Mouse  2357 ANEVRTESSGVILSPGYPGNYFNSQTCAWSIKVEPNFNITLFVDTFQSEKQFDALEVFDGSSGQS 2421

  Fly   160 PW------------------------WRVDLLTPQAVHVVRITTRGCCGHQPLQDLEI------- 193
            |.                        |..|..|.:....:|.....|.....|::..|
Mouse  2422 PLLVVLSGNHTEQSNFTSRSNHLYLRWSTDHATSKKGFKIRYAAPYCSLTSTLRNGGILNKTAGA 2486

  Fly   194 --------------RVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLVGQYVAIQLVGVEGS 244
                          .:|:|:|..:|||:          ||.:..:.| ||. |.|:..:....|:
Mouse  2487 VGSKVHYFCKPGYRMIGHSNATCRRNPV----------GVYQWDSMA-PLC-QAVSCGIPEAPGN 2539

  Fly   245 LSLCEVETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCYDFHITKGESFDKAQ---AICKQTGGDL 306
            .|      ||.:||::|                ||..|:  ..:|...|.:|   .:|::.|
Mouse  2540 GS------FTGNEFTLD----------------SKVTYE--CNEGFKLDASQEATTVCQEDG--- 2577

  Fly   307 VHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNNYN 371
                                       :|....|.|
Mouse  2578 ---------------------------LWSNRGKPP----------------------------- 2586

  Fly   372 GEQNCVVLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVM-----GKKFTLGEKIQ 431
               .|                           .|:.|.|.:.|.:..|:     |.....|.::.
Mouse  2587 ---TC---------------------------KPVPCPSIEGQLSEHVLWRLVSGSLNEYGAQVL 2621

  Fly   432 YTCPKGHSLLGQTERECRLDGTWSGSS--PTCKYVDCGSL---PE-LKFGSIHMSEERTSFGVVA 490
            .:|..|:.|.||...:|:.:||||...  |.||.:.||||   |. .|.|::      |.:|..|
Mouse  2622 LSCSPGYFLQGQRLLQCQANGTWSTEEDRPRCKVISCGSLSFPPNGNKIGTL------TIYGATA 2680

  Fly   491 TYSCHENYTLIGNENRTCAMDG-WSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPG 554
            .::|:..|||:|:..|.|..:| |||.:..||...|..|.||..|.:..:......|..|.|.||
Mouse  2681 IFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCNPG 2745

  Fly   555 YVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTT-TVNSVVKYECDEDHWLD 618
            :.|||.::..|....:||.:||.|..:.||.|..|..|   |.|||. .:|.:|.:.|...:.|.
Mouse  2746 FRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHG---LTNGTEFNLNDLVNFTCHTGYRLQ 2807

  Fly   619 GQSELYCTREGKWSGEAPVCELVTCETP-----SVPSG--SFVIGYDYNVHSKIQYNCDPGHIMH 676
            |.|...|...|:||...|:|.:|.|..|     :|..|  :|...::|.  :.:.|:|..|..:.
Mouse  2808 GASRAQCRSNGQWSSPLPICRVVNCSDPGSVENAVRHGQQNFPESFEYG--TSVMYHCKTGFYLL 2870

  Fly   677 GTPVLECLDSGEWSADAPYCEYIDCGTILP-IPYGSHKYVTNTTYV-GSEVVFSCSQSHKLSGVL 739
            |:..|.|:.||.|....|.|..|.||.  | :|  ::..:|...:. |:.|.:||.....|:|..
Mouse  2871 GSSALTCMASGLWDRSLPKCLAISCGH--PGVP--ANAVLTGELFTYGATVQYSCKGGQILTGNS 2931

  Fly   740 KRTCLESAVWSDASPKCEEIR---CPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKI 801
            .|.|.|.:.||.:.|.|....   |.:|...||.  |..|::                    :|.
Mouse  2932 TRVCQEDSHWSGSLPHCSGNSPGFCGDPGTPAHG--SRLGDE--------------------FKT 2974

  Fly   802 GALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAVL 866
            .:|.::.||.|:::.|.|..||..:|.|||..|.|..|.||.|....|| ::|:::...:.::|:
Mouse  2975 KSLLRFSCEMGHQLRGSAERTCLVNGSWSGVQPVCEAVSCGNPGTPTNG-MILSSDGILFSSSVI 3038

  Fly   867 YECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVATFKCAKGR 931
            |.|...:|.:|:..|.||.:|.|:..||:|..:.|..|....|.|............:::|..|.
Mouse  3039 YACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLPNGIQFGTDFTFNKTVSYQCNPGY 3103

  Fly   932 IM--MGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHCIPNYNRI 994
            :|  ..:.|..|.|:|.|....|.|:.|.|.:|..:.||:  |......:|.|..|.|:..|...
Mouse  3104 LMEPPTSPTIRCTKDGTWNQSRPLCKAVLCNQPPPVPNGK--VEGSDFRWGASISYSCVDGYQLS 3166

  Fly   995 GQYLRKCTEDGAWSGKQPRC 1014
            ...:..|...|.|.|:.|:|
Mouse  3167 HSAILSCEGRGVWKGEVPQC 3186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056	17/54 (31%)
		FTP	113..261	CDD:128870	39/219 (18%)
		CLECT	281..403	CDD:153057	10/124 (8%)
		CCP	408..462	CDD:153056	17/60 (28%)
		CCP	466..520	CDD:153056	21/58 (36%)
		CCP	525..579	CDD:153056	18/53 (34%)
		CCP	583..639	CDD:153056	20/56 (36%)
		PHA02927	637..897	CDD:222943	78/271 (29%)
		CCP	643..697	CDD:153056	16/60 (27%)
		CCP	701..757	CDD:153056	17/57 (30%)
		Sushi	<799..836	CDD:278512	14/36 (39%)
		Sushi	841..896	CDD:278512	18/54 (33%)
		CCP	901..955	CDD:153056	13/55 (24%)
		CCP	959..1015	CDD:153056	16/56 (29%)
Csmd1	XP_036010291.1	CUB	68..175	CDD:238001
		CCP	181..238	CDD:214478
		CUB	244..347	CDD:238001
		CCP	385..443	CDD:153056
		CUB	447..556	CDD:238001
		CCP	563..617	CDD:153056
		CUB	620..727	CDD:238001
		CCP	733..791	CDD:153056
		CUB	794..901	CDD:238001
		CCP	909..962	CDD:153056
		CUB	966..1073	CDD:238001
		CCP	1081..1137	CDD:153056
		CUB	1140..1247	CDD:238001
		CCP	1253..1310	CDD:153056
		CUB	1313..1421	CDD:238001
		CCP	1427..1484	CDD:153056
		CUB	1487..1592	CDD:238001
		CCP	1600..1658	CDD:153056
		CUB	1661..1768	CDD:238001
		CCP	1777..1835	CDD:153056
		CUB	1838..1943	CDD:238001
		CCP	1951..2007	CDD:153056
		CUB	2010..2117	CDD:238001
		CCP	2123..2178	CDD:214478
		CUB	2182..2288	CDD:238001
		CCP	2294..2352	CDD:153056	17/55 (31%)
		CUB	2359..2465	CDD:238001	15/105 (14%)
		PHA02927	<2488..2653	CDD:222943	50/289 (17%)
		PHA02927	2655..2891	CDD:222943	80/246 (33%)
		CCP	2895..2948	CDD:153056	17/56 (30%)
		PHA02927	<2976..3128	CDD:222943	47/152 (31%)
		PHA02927	3068..3307	CDD:222943	32/121 (26%)
		CCP	3311..3367	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10279
eggNOG	1	0.900	-	-		E33208_3BCEG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43710
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810