DRSC/TRiP Functional Genomics Resources

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Protein Alignment fw and SVEP1

DIOPT Version :9

Sequence 1:NP_001285146.1 Gene:fw / 32162 FlyBaseID:FBgn0001083 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_699197.3 Gene:SVEP1 / 79987 HGNCID:15985 Length:3571 Species:Homo sapiens


Alignment Length:1282 Identity:308/1282 - (24%)
Similarity:440/1282 - (34%) Gaps:402/1282 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 LLALCAAGNGQICGPPAVPLNAKVRTI--TVDSQIAEAHYECDAGYELFGPSAVKCDRRTGWDRD 108
            |:..|.|.:   ||.||:|.|..:..:  |..|::.   |.|:.||.|.|.....|...:.|...
Human  1838 LIPYCKAVS---CGKPAIPENGCIEELAFTFGSKVT---YRCNKGYTLAGDKESSCLANSSWSHS 1896

  Fly   109 LPFC-GVNVAYRKPVNQSSYTRSG-----PASYANDGKPGNKNPDGQECSETQKEPSPWWRVDLL 167
            .|.| .|..:..:.:|...|..||     .|||:.|.....:.|...||:.:    ..|.|    
Human  1897 PPVCEPVKCSSPENINNGKYILSGLTYLSTASYSCDTGYSLQGPSIIECTAS----GIWDR---- 1953

  Fly   168 TPQAVHVVRITTRGCCGHQP-LQDLEIRVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLVG 231
            .|.|.|:|      .||..| ::|..|...|.:.   ||.:              |:||..    
Human  1954 APPACHLV------FCGEPPAIKDAVITGNNFTF---RNTV--------------TYTCKE---- 1991

  Fly   232 QYVAIQLVGVEGSLSLCEVETFTNDEFSVDRCLS-----PKI----GVDTVVTTFSKTCYDFHIT 287
               ...|.|::....|.:.:...:|:    :||:     |.|    ..:|....|....: ::.:
Human  1992 ---GYTLAGLDTIECLADGKWSRSDQ----QCLAVSCDEPPIVDHASPETAHRLFGDIAF-YYCS 2048

  Fly   288 KGESF-DKAQAICKQTG------GD-----LVHDFRGATS-SY-ILSELERRK------------ 326
            .|.|. |.:|.:|...|      |.     :.|......| || ||..:.:.|            
Human  2049 DGYSLADNSQLLCNAQGKWVPPEGQDMPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCM 2113

  Fly   327 ---------------------SELKPQLVWIGAQKEPGITS------------------------ 346
                                 |.:..|.:.:...:.|.|.:                        
Human  2114 EGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEPPSIMNGYASGSNYSFGAMVAYSCNKGFYI 2178

  Fly   347 ---------RTWKWVNGDVVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVG----------C 392
                     .|.:|.:......|....:.|...||            :|.:..|          |
Human  2179 KGEKKSTCEATGQWSSPIPTCHPVSCGEPPKVENG------------FLEHTTGRIFESEVRYQC 2231

  Fly   393 NLDYLH-----FICQ-----HS-------PLSCGSPDAQQNTTVMGKKFTLGEKIQYTCPKGHSL 440
            |..|..     |:||     ||       ||.||.|...||..:.|:.|.:|.|:|:.|.:|:.|
Human  2232 NPGYKSVGSPVFVCQANRHWHSESPLMCVPLDCGKPPPIQNGFMKGENFEVGSKVQFFCNEGYEL 2296

  Fly   441 LGQTERECRLDGTWSGSS----------------------------------------------- 458
            :|.:...|:..|.|:..|                                               
Human  2297 VGDSSWTCQKSGKWNKKSNPKCMPAKCPEPPLLENQLVLKELTTEVGVVTFSCKEGHVLQGPSVL 2361

  Fly   459 ------------PTCKYVDCGSLPELKFGSIHMSEERTSFGVVATYSCHENYTLIGNENRTCAMD 511
                        |.||.|.|...|.:.|| :.:......||....|||...:.|.||....|..|
Human  2362 KCLPSQQWNDSFPVCKIVLCTPPPLISFG-VPIPSSALHFGSTVKYSCVGGFFLRGNSTTLCQPD 2425

  Fly   512 G-WSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAIISCGLGGEWSSKT 575
            | ||...|||:...||.|:.|..|.:........|||.|.|:||:.|||.....||..|.|....
Human  2426 GTWSSPLPECVPVECPQPEEIPNGIIDVQGLAYLSTALYTCKPGFELVGNTTTLCGENGHWLGGK 2490

  Fly   576 PSCRFVDCGAPARPNRGIAILLNGTTTVNSV-----VKYECDEDHWLDGQSELYCTREGKWSGEA 635
            |:|:.::|..|..       :|||..:...:     |.|.|:....|:|.|.|.|...|.|..:|
Human  2491 PTCKAIECLKPKE-------ILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDA 2548

  Fly   636 PVCELVTCETPSVPSGSFVIGYDYN---------------------------------------- 660
            |.|..:.|::|......||.|.||:                                        
Human  2549 PSCNAIHCDSPQPIENGFVEGADYSYGAIIIYSCFPGFQVAGHAMQTCEESGWSSSIPTCMPIDC 2613

  Fly   661 --------------------------------------------------------VHSK----- 664
                                                                    .||.     
Human  2614 GLPPHIDFGDCTKLKDDQGYFEQEDDMMEVPYVTPHPPYHLGAVAKTWENTKESPATHSSNFLYG 2678

  Fly   665 --IQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDCGTILP-IPYGSHKYVTNTTYVGSEVV 726
              :.|.|:||:.:.|.|||.|.:.|.|:..||.|..|:|.  || .|.......|.|: :||.|.
Human  2679 TMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECD--LPTAPENGFLRFTETS-MGSAVQ 2740

  Fly   727 FSCSQSHKLSGVLKRTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSES 791
            :||...|.|:|...|.|||:..||.|||:||.|.|.:|....:.  |:.|::..|..||.     
Human  2741 YSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNG--SIKGSNYTYLSTLY----- 2798

  Fly   792 SQNTAQTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLAT 856
                           |.|:.||.:.|....||.|...|....|.|:.|:|.:|....||:|  ..
Human  2799 ---------------YECDPGYVLNGTERRTCQDDKNWDEDEPICIPVDCSSPPVSANGQV--RG 2846

  Fly   857 NATYYGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGS 921
            :...:...:.|.||..|.|.|...|:|..:|:||...|:||.|.|.||....|.:.|........
Human  2847 DEYTFQKEIEYTCNEGFLLEGARSRVCLANGSWSGATPDCVPVRCATPPQLANGVTEGLDYGFMK 2911

  Fly   922 VATFKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYH 986
            ..||.|.:|.|:.|.....||.:|.|..:.|.|:||:||.|..:.:|  .....|.::||..:|.
Human  2912 EVTFHCHEGYILHGAPKLTCQSDGNWDAEIPLCKPVNCGPPEDLAHG--FPNGFSFIHGGHIQYQ 2974

  Fly   987 CIPNYNRIGQYLRKCTEDGAWSGKQPRC----------ELATAEGQE 1023
            |.|.|...|...|:|..:|:|||..|.|          |..|..|.:
Human  2975 CFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVIEYGTVNGTD 3021

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwNP_001285146.1 CCP 58..112 CDD:153056 17/55 (31%)
FTP 113..261 CDD:128870 33/153 (22%)
CLECT 281..403 CDD:153057 32/221 (14%)
CCP 408..462 CDD:153056 19/112 (17%)
CCP 466..520 CDD:153056 18/54 (33%)
CCP 525..579 CDD:153056 20/53 (38%)
CCP 583..639 CDD:153056 17/60 (28%)
PHA02927 637..897 CDD:222943 87/363 (24%)
CCP 643..697 CDD:153056 22/156 (14%)
CCP 701..757 CDD:153056 23/56 (41%)
Sushi <799..836 CDD:278512 10/36 (28%)
Sushi 841..896 CDD:278512 17/54 (31%)
CCP 901..955 CDD:153056 16/53 (30%)
CCP 959..1015 CDD:153056 20/65 (31%)
SVEP1NP_699197.3 VWA 84..258 CDD:278519
GCC2_GCC3 310..360 CDD:285001
CCP 378..434 CDD:153056
CCP 438..494 CDD:153056
DUF5011 560..642 CDD:295940
DUF5011 643..722 CDD:295940
O-glycosylated at one site 887..894
GCC2_GCC3 1005..1052 CDD:285001
GCC2_GCC3 1059..1106 CDD:285001
GCC2_GCC3 1113..1160 CDD:285001
EGF 1197..1225 CDD:278437
EGF_CA 1231..1267 CDD:238011
EGF_CA 1269..1305 CDD:238011
EGF_CA 1308..1342 CDD:238011
EGF_CA 1345..1381 CDD:238011
EGF_CA 1383..1419 CDD:238011
LamG 1424..1622 CDD:304605
Sushi 1628..1685 CDD:278512
CCP 1690..1743 CDD:153056
EGF_CA 1745..1783 CDD:214542
PHA02927 1789..2017 CDD:222943 54/226 (24%)
CCP 1789..1843 CDD:153056 1/4 (25%)
CCP 1847..1901 CDD:153056 17/56 (30%)
CCP 1905..1958 CDD:153056 14/60 (23%)
CCP 1963..2016 CDD:153056 15/80 (19%)
Sushi 2021..2078 CDD:278512 11/57 (19%)
CCP 2083..2136 CDD:153056 6/52 (12%)
PHA02927 2137..2376 CDD:222943 40/250 (16%)
CCP 2146..2199 CDD:153056 4/52 (8%)
CCP 2204..2260 CDD:153056 13/67 (19%)
CCP 2264..2318 CDD:153056 18/53 (34%)
CCP 2323..2377 CDD:153056 1/53 (2%)
CCP 2381..2436 CDD:153056 19/55 (35%)
CCP 2440..2494 CDD:153056 20/53 (38%)
PHA02927 2498..2770 CDD:222943 65/281 (23%)
CCP 2498..2551 CDD:214478 17/59 (29%)
CCP 2556..2608 CDD:153056 7/51 (14%)
CCP <2670..2713 CDD:153056 15/42 (36%)
CCP 2717..2771 CDD:153056 23/56 (41%)
PHA02927 2770..3003 CDD:222943 80/258 (31%)
CCP 2775..2828 CDD:214478 17/74 (23%)
CCP 2833..2887 CDD:153056 17/55 (31%)
Cell attachment site. /evidence=ECO:0000255 2845..2847 0/1 (0%)
CCP 2891..2945 CDD:153056 16/53 (30%)
CCP 2949..3002 CDD:214478 19/54 (35%)
Sushi 3007..3059 CDD:278512 3/15 (20%)
CCP 3064..3118 CDD:153056
Sushi 3181..3231 CDD:278512
CCP 3241..3295 CDD:153056
CCP 3299..3353 CDD:153056
CCP 3357..3412 CDD:153056
CCP 3416..3469 CDD:153056
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 52 1.000 Domainoid score I11440
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41663
orthoMCL 1 0.900 - - OOG6_102627
Panther 1 1.100 - - LDO PTHR19325
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3908
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.940

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