DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and selp

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001230252.1	Gene:	selp / 796481	ZFINID:	ZDB-GENE-110107-2	Length:	868	Species:	Danio rerio

Alignment Length:	833	Identity:	203/833 - (24%)
Similarity:	306/833 - (36%)	Gaps:	192/833 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 YDFHITKGESFDKAQAICKQTGGDLVHDFRGATSSYILSELERRKSELKP---QLVWIGAQKEPG 343
            |.::|.....:..|:..|:....|:|.....|..:|:        :|:.|   ...|||.:|..|
Zfish    28 YHYNIDSKLDWTAARQWCQTHFTDMVAIQNQAEIAYL--------NEILPFHRAYYWIGIRKIDG 84

  Fly   344 ITSRTWKWVNGD---VVQKPTWGKDQPNNYNGEQNCVVLDGGRN---WLWNDVGCNLD--YLHFI 400
                .|.||...   .|:...|..::|||....::||.:...||   ..|||..|:..  .:.::
Zfish    85 ----HWTWVGTKKRLTVEAANWATNEPNNQGTGEDCVEIYIKRNKDTAKWNDERCSKKKATVCYL 145

  Fly   401 CQHSPLSC----------GSPDAQQNTTVMGKKF------------------TLGE-----KIQY 432
            ...:.:||          |:...|.:...||.:|                  ..||     ..|:
Zfish   146 ASCTEISCSEHARCVETIGNYTCQCDAGFMGPRFVQCQPVENPQQGLVKCDGAFGEFNFNSSCQF 210

  Fly   433 TCPKGHSLLGQTERECRLDGTWSGSSPTCKYVDCGSLPELKFGSIHMSEERTSFGVVATYSCHEN 497
            .|..|.:|:|.....|...|.|:.:.|.|:.|.|.::.:...|
Zfish   211 QCATGFNLVGAERIHCLTTGHWNDTLPVCQAVKCQAIIDAPRG---------------------- 253

  Fly   498 YTLIGNENRTCAMDGWSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAI 562
            :|:|                       |..|..:..    ||     |:..:.|:.|:.|.|...
Zfish   254 WTMI-----------------------CTHPLSMNS----FN-----SSCEFECKEGFELNGSKT 286

  Fly   563 ISCGLGGEWSSKTPSCRFVDCG---APARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELY 624
            ..|...|.|:.|.|:|..|.|.   |||..:...|..| |.::..|.....|||.:.|.|::.|.
Zfish   287 TWCDHTGHWTDKAPTCTVVTCNPLLAPANSSLACADPL-GKSSFRSSCNVTCDEGYKLRGRAALT 350

  Fly   625 CTREGKWSGEAPVCELVTCET-PSVPSGSFVIGYDYNVHSKIQ---------YNCDPGHIMHGTP 679
            |.|||.||...||||:|.|:: ..:.:||      |..|..:.         :.||.|.:.:||.
Zfish   351 CQREGNWSAPLPVCEVVKCDSLKPIANGS------YQCHDSVDEFSYGSTCWFKCDSGFVHNGTN 409

  Fly   680 VLECLDSGEWSADAPYCEYIDCGTILPIP-YGS----HKYVTNTTYVGSEVVFSCSQSHKLSGVL 739
            ...|...|.||..:|.|..:.|..:...| |||    |...||:  ..|...|.|.:...|.|..
Zfish   410 STHCTKQGNWSHISPICHAVQCPPLSDTPKYGSVSCVHPLSTNS--YNSSCEFKCEEGLVLRGTD 472

  Fly   740 KRTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGAL 804
            ...|..:..|::.:|.|..:.|.......:|.|:..   ...|:...|||
Zfish   473 STHCDHTGHWTNTAPICTAVACDPLVTPVNSNLTCA---NPLGKFSFRTS--------------- 519

  Fly   805 AKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKV----VLATNATYYGAAV 865
            .:..||.|||:.|:....|..:|.||...|.|..:.|.|.|.:::|.|    :|...:  ||:..
Zfish   520 CEVICEVGYKLRGDTTLNCLSNGNWSAPTPACKVIRCEALESVHHGSVHCHDLLEEFS--YGSEC 582

  Fly   866 LYECNVNFKLNGVSRRLCTEHGNWSHEAPECV-------------EVVCDTPNINENLIVEAGPR 917
            ..||...|.|||.:...||..|.|..|...|.             .:.|..|:         |..
Zfish   583 WLECEAGFTLNGTNSTYCTSQGKWKQELSVCQAQQCSSLTDPSHGSLTCTHPH---------GQF 638

  Fly   918 AVGSVATFKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGS 982
            :.|:|....|..|..:.|.....|.:.||||...|.|...:|....|.|||.:...:..:|:  |
Zfish   639 SFGTVCEVSCQAGFKLHGTPKMECLEMGKWTDTPPFCLAQECPLLSAPENGWMNCSHPHSLF--S 701

  Fly   983 AEYHCI----PNYNRIGQYLRKCTEDGAWSGKQPRCELATAEG---QETSELG 1028
            .|..|:    ..:...|:...:|:..|.||.:.|.|.:...|.   ...|:||
Zfish   702 YESQCLLGCETGFELTGEPDIQCSASGNWSQEMPSCAVVHCEPLWLTHLSDLG 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870
		CLECT	281..403	CDD:153057	31/131 (24%)
		CCP	408..462	CDD:153056	17/86 (20%)
		CCP	466..520	CDD:153056	4/53 (8%)
		CCP	525..579	CDD:153056	14/53 (26%)
		CCP	583..639	CDD:153056	22/58 (38%)
		PHA02927	637..897	CDD:222943	75/278 (27%)
		CCP	643..697	CDD:153056	15/63 (24%)
		CCP	701..757	CDD:153056	16/60 (27%)
		Sushi	<799..836	CDD:278512	11/36 (31%)
		Sushi	841..896	CDD:278512	19/58 (33%)
		CCP	901..955	CDD:153056	14/53 (26%)
		CCP	959..1015	CDD:153056	15/59 (25%)
selp	NP_001230252.1	CLECT_selectins_like	26..144	CDD:153062	31/127 (24%)
		EGF_CA	<153..178	CDD:238011	5/24 (21%)
		CCP	<200..364	CDD:332582	54/218 (25%)
		CCP	<324..489	CDD:332582	52/173 (30%)
		CCP	521..737	CDD:332582	62/228 (27%)
		CCP	751..806	CDD:153056	3/4 (75%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I3335
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002067
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.050