DRSC/TRiP Functional Genomics Resources

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Protein Alignment fw and Svep1

DIOPT Version :10

Sequence 1:NP_511136.2 Gene:fw / 32162 FlyBaseID:FBgn0001083 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_073725.2 Gene:Svep1 / 64817 MGIID:1928849 Length:3567 Species:Mus musculus


Alignment Length:1261 Identity:301/1261 - (23%)
Similarity:444/1261 - (35%) Gaps:361/1261 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 AHYECDAGYELFGPSAVKCDRRTGWDRDLPFC-----------------------GVNVAYRKPV 122
            |.|.|:.||.|.|||.::|.....|||..|.|                       |..|||   .
Mouse  1926 ASYSCENGYSLQGPSLLECTASGSWDRAPPSCQLVSCGEPPIVKDAVITGSNFTFGNTVAY---T 1987

  Fly   123 NQSSYTRSGP---ASYANDGKPGNKNPDGQECSETQKEPSPWWRVDLLTPQAVHVVRITTR--GC 182
            .:..||.:||   ...||    |..|....:|.....:..|  .||..:|:..|.:...|.  .|
Mouse  1988 CKEGYTLAGPDTIVCQAN----GKWNSSNHQCLAVSCDEPP--NVDHASPETAHRLFGDTAFYYC 2046

  Fly   183 CGHQPLQDLEIRVGNSSADL-----QRNPLCAWY----PGTLDEGVVKTFTCARPLVGQYVAIQL 238
            .....|.|....:.|:..:.     |..|.|..:    |.::...::::.:.|:...|..|:.:.
Mouse  2047 ADGYSLADNSQLICNAQGNWVPPAGQAVPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKC 2111

  Fly   239 VGVEGSL--SLCEVETFTNDEFSVD----RCLSPKIGVDTVV-------TTFS------KTCYDF 284
              :||.:  :..::|.....|:|..    :|:..:.|....:       |.:|      .:|:..
Mouse  2112 --MEGFVLNTSAKIECLRGGEWSPSPLSVQCIPVRCGEPPSIANGYPSGTNYSFGAVVAYSCHKG 2174

  Fly   285 HITKGESFDKAQAICKQTGGDLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTW 349
            ...|||.    ::.|:.||                                              
Mouse  2175 FYIKGEK----KSTCEATG---------------------------------------------- 2189

  Fly   350 KWVNGDVVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVG----------CNLDYLH-----F 399
            :|........|....:.|...||            :|.:..|          ||..|..     |
Mouse  2190 QWSKPTPTCHPVSCNEPPKVENG------------FLEHTTGRTFESEARFQCNPGYKAAGSPVF 2242

  Fly   400 ICQ-----HS-------PLSCGSPDAQQNTTVMGKKFTLGEKIQYTC------------------ 434
            :||     ||       ||:||.|...||..:.|:.|.:|.|:|:.|                  
Mouse  2243 VCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLKGESFEVGSKVQFVCNEGYELVGDNSWTCQKSG 2307

  Fly   435 -------PK----------------------------------GHSLLGQTERECRLDGTWSGSS 458
                   ||                                  ||:|.|.:..:|...|.|:||.
Mouse  2308 KWSKKPSPKCVPTKCAEPPLLENQLVLKELASEVGVMTISCKEGHALQGPSVLKCLPSGQWNGSF 2372

  Fly   459 PTCKYVDCGSLPELKFGSIHMSEERTSFGVVATYSCHENYTLIGNENRTCAMDG-WSGKQPECLV 522
            |.||.|.|.|.|.:.|| :..|.....||....|.|.:.:.|.|:....|..|. ||...|||:.
Mouse  2373 PICKMVLCPSPPLIPFG-VPASSGALHFGSTVKYLCVDGFFLRGSPTILCQADSTWSSPLPECVP 2436

  Fly   523 DWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPA 587
            ..||.|:.|..|.:........||..|.|:||:.|||.|...||..|:|....|.|:.::|..|.
Mouse  2437 VECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNATTLCGENGQWLGGKPMCKPIECPEPK 2501

  Fly   588 RPNRGIAILLNG-----TTTVNSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVCELVTCETPS 647
            .       :|||     :......:.|.||....|:|...|.|...|.|..:.|.|:.:.|..|.
Mouse  2502 E-------ILNGQFSSVSFQYGQTITYFCDRGFRLEGPKSLTCLETGDWDMDPPSCDAIHCSDPQ 2559

  Fly   648 VPSGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDCG---------- 702
            .....||.|.||...:.|.|:|.||..:.|..:..|.:|| ||:.:|.|..||||          
Mouse  2560 PIENGFVEGADYRYGAMIIYSCFPGFQVLGHAMQTCEESG-WSSSSPTCVPIDCGLPPHIDFGDC 2623

  Fly   703 --------------TILPIPYGSH--------KYVTNTT----------YVGSEVVFSCSQSHKL 735
                          .::.:||.:|        |.:.||.          ..|:.|.:||...::|
Mouse  2624 TKVRDGQGHFDQEDDMMEVPYLAHPQHLEATAKALENTKESPASHASHFLYGTMVSYSCEPGYEL 2688

  Fly   736 SGVLKRTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYK 800
            .|:....|.|...|:..:|.|..|.|..|....:..|..|                 |.|     
Mouse  2689 LGIPVLICQEDGTWNGTAPSCISIECDLPVAPENGFLHFT-----------------QTT----- 2731

  Fly   801 IGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAV 865
            :|:.|:|.|:.|:.:.|..|..|..:.|||||:|.|..:.|..|..:.||. :...:.:|.| .:
Mouse  2732 MGSAAQYSCKPGHILEGSHLRLCLQNKQWSGTVPRCEAISCSKPNPLWNGS-IKGDDYSYLG-VL 2794

  Fly   866 LYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVATFKCAKG 930
            .|||:..:.|||..:|.|.|:.:|....|.|:.|.|.:|.:..|..|:..........|:.|.:|
Mouse  2795 YYECDSGYILNGSKKRTCQENRDWDGHEPMCIPVDCGSPPVPTNGRVKGEEYTFQKEITYSCREG 2859

  Fly   931 RIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENG--------------------------- 968
            .|:.|..:|:|..||.|:|.:|:|.||.|..|..:.||                           
Mouse  2860 FILEGARSRICLTNGSWSGATPSCMPVRCPAPPQVPNGVADGLDYGFKKEVAFHCLEGYVLQGAP 2924

  Fly   969 ------------RVIVVNDST-----------------LYGGSAEYHCIPNYNRIGQYLRKCTED 1004
                        .|.|...:|                 .:||..:|.|...|...|...|:|..:
Mouse  2925 RLTCQSNGTWDAEVPVCKPATCGPPADLPQGFPNGFSFYHGGHIQYQCFTGYKLHGNPSRRCLPN 2989

  Fly  1005 GAWSGKQPR---CELATAEGQETSELGTGVGIGATVIVALLVIFGLIFL------YRNKARPVKN 1060
            |:|||..|.   |..:|...|:.:...|.:|.|.||.:.....|.|:.|      ...:...|..
Mouse  2990 GSWSGSSPSCLPCRCSTPIIQQGTINATDLGCGKTVQIECFKGFKLLGLSEITCDANGQWSDVPL 3054

  Fly  1061 TENVQAAETKDERNAAVMSYSTLEAN 1086
            .|:.|........||.|:..|..|.|
Mouse  3055 CEHAQCGPLPTIPNAIVLEGSLSEDN 3080

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwNP_511136.2 CCP 58..112 CDD:153056 14/30 (47%)
FTP 113..261 CDD:128870 35/163 (21%)
CLECT 281..403 CDD:153057 20/141 (14%)
PHA02927 <408..578 CDD:222943 65/229 (28%)
PHA02927 <508..696 CDD:222943 63/193 (33%)
PHA02639 643..>837 CDD:165022 62/235 (26%)
PHA02927 798..1014 CDD:222943 73/274 (27%)
Svep1NP_073725.2 VWA 84..259 CDD:459670
Ephrin_rec_like 311..361 CDD:429604
CCP 379..435 CDD:153056
CCP 439..495 CDD:153056
CCP <514..556 CDD:153056
HYR 560..642 CDD:460572
HYR 644..722 CDD:460572
Ephrin_rec_like 1004..1051 CDD:429604
Ephrin_rec_like 1058..1105 CDD:429604
Ephrin_rec_like 1112..1159 CDD:429604
EGF_CA 1195..1228 CDD:238011
EGF_CA 1230..1266 CDD:238011
EGF_CA 1268..1304 CDD:238011
EGF_CA 1306..1342 CDD:238011
EGF_CA 1344..1380 CDD:238011
EGF_CA 1382..1418 CDD:238011
PTX 1423..1621 CDD:238086
PHA02927 1643..1899 CDD:222943
EGF_3 1748..1782 CDD:463759
PHA02817 1899..>2008 CDD:165167 26/88 (30%)
PHA02927 1957..2198 CDD:222943 48/301 (16%)
PHA02927 2093..2318 CDD:222943 49/288 (17%)
PHA02831 2277..>2435 CDD:165176 38/158 (24%)
PHA02927 2400..2608 CDD:222943 68/215 (32%)
Important for the interaction with integrin ITGA9:ITGB1. /evidence=ECO:0000269|PubMed:22654117 2638..2645 1/6 (17%)
CCP <2670..2710 CDD:153056 10/39 (26%)
PHA02927 2709..2941 CDD:222943 66/255 (26%)
PHA02927 2903..3113 CDD:222943 36/178 (20%)
PHA02927 3012..3225 CDD:222943 17/69 (25%)
PHA02927 3232..3464 CDD:222943
Blue background indicates that the domain is not in the aligned region.

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