DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fw and CSMD1

DIOPT Version :9

Sequence 1:NP_001285146.1 Gene:fw / 32162 FlyBaseID:FBgn0001083 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_150094.5 Gene:CSMD1 / 64478 HGNCID:14026 Length:3564 Species:Homo sapiens


Alignment Length:1310 Identity:306/1310 - (23%)
Similarity:457/1310 - (34%) Gaps:411/1310 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 PPAVPLNAKVRTITVDSQIAE-AHYECDAGYELFGPSAVKC--DRRTGWDRDLPFCGVNVAYRKP 121
            ||||| .|::.|...|.:|.: ..|:|..||.|.|...:.|  ..:..::..||.|....    |
Human  2261 PPAVP-QAEMLTEDDDFEIGDFVKYQCHPGYTLVGTDILTCKLSSQLQFEGSLPTCE
AQC----P 2320

  Fly   122 VNQSSYTRSGPAS-YANDGKPGNKNPDGQECSETQK-EP-------------------------- 158
            .|:   .|:|.:. ..:.|.|||.. :.|.||.:.| ||                          
Human  2321 ANE---VRTGSSGVILSPGYPGNYF-NSQTCSWSIKVEPNYNITIFVDTFQSEKQFDALEVFDGS 2381

  Fly   159 ---SPW------------------------WRVDLLTPQAVHVVRITTRGCCGHQPLQDLEI--- 193
               ||.                        |..|..|.:....:|.....|....||::..|   
Human  2382 SGQSPLLVVLSGNHTEQSNFTSRSNQLYLRWSTDHATSKKGFKIRYAAPYCSLTHPLKNGGILNR 2446

  Fly   194 ------------------RVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLVGQYVAIQLVG 240
                              .||:|:|..:||||..:...:|.. :.:..:|..|        :..|
Human  2447 TAGAVGSKVHYFCKPGYRMVGHSNATCRRNPLGMYQWDSLTP-LCQAVSCGIP--------ESPG 2502

  Fly   241 VEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCYDFHI-TKGESFDKAQAICKQTGG 304
             .||        ||.:||::|                ||..|:.|. .|.||..:|.|:|::.| 
Human  2503 -NGS--------FTGNEFTLD----------------SKVVYECHEGFKLESSQQATAVCQEDG- 2541

  Fly   305 DLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNN 369
                                         :|....|.|                           
Human  2542 -----------------------------LWSNKGKPP--------------------------- 2550

  Fly   370 YNGEQNCVVLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVM-----GKKFTLGEK 429
                 .|                           .|::|.|.:||.:..|:     |.....|.:
Human  2551 -----TC---------------------------KPVACPSIEAQLSEHVIWRLVSGSLNEYGAQ 2583

  Fly   430 IQYTCPKGHSLLGQTERECRLDGTWS--GSSPTCKYVDCGSL---PE-LKFGSIHMSEERTSFGV 488
            :..:|..|:.|.|.....|:.:|||:  ...|:|:.:.||||   |. .|.|::      |.:|.
Human  2584 VLLSCSPGYYLEGWRLLRCQANGTWNIGDERPSCRVISCGSLSFPPNGNKIGTL------TVYGA 2642

  Fly   489 VATYSCHENYTLIGNENRTCAMDG-WSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCE 552
            .|.::|:..|||:|:..|.|..:| |||.:..||...|..|.||..|.:..:......|..|.|.
Human  2643 TAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVYQCN 2707

  Fly   553 PGYVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTT-TVNSVVKYECDEDHW 616
            ||:.|||.::..|....:||.:||.|..:.||.|..|..|..   ||:. .:|.||.:.|:..:.
Human  2708 PGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHGFT---NGSEFNLNDVVNFTCNTGYL 2769

  Fly   617 LDGQSELYCTREGKWSGEAPVCELVTCETP-----SVPSG--SFVIGYDYNVHSKIQYNCDPGHI 674
            |.|.|...|...|:||...|.|.:|.|..|     ::..|  :|...::|.:  .|.|:|..|..
Human  2770 LQGVSRAQCRSNGQWSSPLPTCRVVNCSDPGFVENAIRHGQQNFPESFEYGM--SILYHCKKGFY 2832

  Fly   675 MHGTPVLECLDSGEWSADAPYCEYIDCG-------TILP---------IPY---GSHKYVTNTTY 720
            :.|:..|.|:.:|.|....|.|..|.||       .:|.         :.|   ||...:.|.|.
Human  2833 LLGSSALTCMANGLWDRSLPKCLAISCGHPGVPANAVLTGELFTYGAVVHYSCRGSESLIGNDTR 2897

  Fly   721 VGSE----------------------------------------VVFSCSQSHKLSGVLKRTCLE 745
            |..|                                        :.|||...|:|.|..:||||.
Human  2898 VCQEDSHWSGALPHCTGNNPGFCGDPGTPAHGSRLGDDFKTKSLLRFSCEMGHQLRGSPERTCLL 2962

  Fly   746 SAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCE 810
            :..||...|.||.:.|..|....:.:: |:.:..::..::|                    |.|.
Human  2963 NGSWSGLQPVCEAVSCGNPGTPTNGMI-VSSDGILFSSSVI--------------------YACW 3006

  Fly   811 RGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAVLYECNVNFKL 875
            .|||..|.....||.:|.|:||.|:|..:.||.|..:.|| :...|:.| :...|.|:||..:.:
Human  3007 EGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLANG-IQFGTDFT-FNKTVSYQCNPGYVM 3069

  Fly   876 NGVSRRL--CTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVATFKCAKGRIMMGNDT 938
            ..|:...  ||:.|.|:...|.|..|:|..|...:|..||......||..::.|..|..:..:..
Human  3070 EAVTSATIRCTKDGRWNPSKPVCKAVLCPQPPPVQNGTVEGSDFRWGSSISYSCMDGYQLSHSAI 3134

  Fly   939 RVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHCIPNYNRIGQYLRKCTE 1003
            ..|:..|.|.|:.|.|.||.||.|.....||  :...|..|.....:.|...:..:|...|.|..
Human  3135 LSCEGRGVWKGEIPQCLPVFCGDPGIPAEGR--LSGKSFTYKSEVFFQCKSPFILVGSSRRVCQA 3197

  Fly  1004 DGAWSGKQPRC---ELATAEGQETSELG-----TGVGIGATVIVALLVIFGLIFLYRNKARPVKN 1060
            ||.|||.||.|   ...|.....|...|     .|..:|:||            .:|     .:.
Human  3198 DGTWSGIQPTCIDPAHNTCPDPGTPHFGIQNSSRGYEVGSTV------------FFR-----CRK 3245

  Fly  1061 TENVQAAETKDERNAAVMSYSTLEANNRMHMDNNPSA------------TFN-----TFHGG--- 1105
            ..::|.:.|:  ...|.:::|.::.....|....|..            ||.     |.|.|   
Human  3246 GYHIQGSTTR--TCLANLTWSGIQTECIPHACRQPETPAHADVRAIDLPTFGYTLVYTCHPGFFL 3308

  Fly  1106 AGGRSN---------GGGNPDANSNGERLNNNRSENIYDQIPNEQFYDAPYEMRTNDEVYEPEPV 1161
            |||..:         .|.:|...|.|                          :|..:|.....||
Human  3309 AGGSEHRTCKADMKWTGKSPVCKSKG--------------------------VREVNETVTKTPV 3347

  Fly  1162 ASNVITINGI 1171
            .|:|..:|.:
Human  3348 PSDVFFVNSL 3357

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwNP_001285146.1 CCP 58..112 CDD:153056 18/54 (33%)
FTP 113..261 CDD:128870 42/223 (19%)
CLECT 281..403 CDD:153057 13/122 (11%)
CCP 408..462 CDD:153056 16/60 (27%)
CCP 466..520 CDD:153056 21/58 (36%)
CCP 525..579 CDD:153056 18/53 (34%)
CCP 583..639 CDD:153056 19/56 (34%)
PHA02927 637..897 CDD:222943 79/327 (24%)
CCP 643..697 CDD:153056 15/60 (25%)
CCP 701..757 CDD:153056 23/114 (20%)
Sushi <799..836 CDD:278512 13/36 (36%)
Sushi 841..896 CDD:278512 17/56 (30%)
CCP 901..955 CDD:153056 14/53 (26%)
CCP 959..1015 CDD:153056 19/58 (33%)
CSMD1NP_150094.5 CUB 32..139 CDD:238001
CCP 145..202 CDD:214478
CUB 208..311 CDD:238001
CCP 349..407 CDD:153056
CUB 411..520 CDD:238001
CCP 527..581 CDD:153056
CUB 584..691 CDD:238001
CCP 697..755 CDD:153056
CUB 758..865 CDD:238001
CCP 873..926 CDD:153056
CUB 930..1038 CDD:238001
CCP 1045..1101 CDD:153056
CUB 1104..1211 CDD:238001
CCP 1217..1274 CDD:153056
CUB 1277..1385 CDD:238001
CCP 1391..1448 CDD:153056
CUB 1451..1556 CDD:238001
CCP 1564..1621 CDD:153056
CUB 1625..1732 CDD:238001
CCP 1741..1799 CDD:153056
CUB 1802..1907 CDD:238001
CCP 1915..1971 CDD:153056
CUB 1974..2081 CDD:238001
CCP 2087..2142 CDD:153056
CUB 2146..2252 CDD:238001
CCP 2258..2316 CDD:153056 18/55 (33%)
CUB 2323..2429 CDD:238001 18/109 (17%)
CCP <2452..2617 CDD:332582 51/287 (18%)
CCP 2619..2855 CDD:332582 78/246 (32%)
CCP 2859..2912 CDD:153056 10/52 (19%)
CCP <2933..3092 CDD:332582 50/181 (28%)
CCP 3032..3271 CDD:332582 68/261 (26%)
CCP 3275..3331 CDD:153056 11/55 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10337
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41663
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.910

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