DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and SELP

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_002996.2	Gene:	SELP / 6403	HGNCID:	10721	Length:	830	Species:	Homo sapiens

Alignment Length:	879	Identity:	219/879 - (24%)
Similarity:	341/879 - (38%)	Gaps:	152/879 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 CEV----ETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCYDFHI-TKGESFDKAQAICKQTGGDLV 307
            |::    :.|....|.:.:.|.....:..:........:.:|. ||..|::.::..|:....|||
Human     4 CQIAILYQRFQRVVFGISQLLCFSALISELTNQKEVAAWTYHYSTKAYSWNISRKYCQNRYTDLV 68

  Fly   308 H-------DFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVV---QKPTW 362
            .       |:......|..|            ..|||.:|    .::||.||.....   :...|
Human    69 AIQNKNEIDYLNKVLPYYSS------------YYWIGIRK----NNKTWTWVGTKKALTNEAENW 117

  Fly   363 GKDQPNNYNGEQNCV---VLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVMGKKF 424
            ..::|||....::||   :........|||..| |...|.:|..:  ||......:....:.
Human   118 ADNEPNNKRNNEDCVEIYIKSPSAPGKWNDEHC-LKKKHALCYTA--SCQDMSCSKQGECLE--- 176

  Fly   425 TLGEKIQYTCPKGHSLLGQTERECRLDGTWSGSSPTCKYV-DCG--SLPELKFGSIHMSEERTSF 486
            |:|   .|||.......|                |.|:|| :||  .||:....:........||
Human   177 TIG---NYTCSCYPGFYG----------------PECEYVRECGELELPQHVLMNCSHPLGNFSF 222

  Fly   487 GVVATYSCHENYTLIGNENRTCAMDG-WSGKQPECLVDWCPDPQ-PIAGGDVRFNDKRA---GST 546
            ....::.|.:.|.:.|.....|...| |:.|.|:||...||..: |..|.....:..:|   .|:
Human   223 NSQCSFHCTDGYQVNGPSKLECLASGIWTNKPPQCLAAQCPPLKIPERGNMTCLHSAKAFQHQSS 287

  Fly   547 ATYVCEPGYVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTT--TVNSVVKY 609
            .::.||.|:.|||..::.|...|.|::..|.|:.|.|.....|:.|....::..|  ...|..|:
Human   288 CSFSCEEGFALVGPEVVQCTASGVWTAPAPVCKAVQCQHLEAPSEGTMDCVHPLTAFAYGSSCKF 352

  Fly   610 ECDEDHWLDGQSELYCTREGKWSGEAPVCELVTCETPSVP-SGSF-------VIGYDYNVHSKIQ 666
            ||...:.:.|...|.|...|.||...|.||.::||....| .||.       ...||.|    ..
Human   353 ECQPGYRVRGLDMLRCIDSGHWSAPLPTCEAISCEPLESPVHGSMDCSPSLRAFQYDTN----CS 413

  Fly   667 YNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDCGTILPI----------PYGSHKYVTNTTYV 721
            :.|..|.::.|..::.|.:.|:|:|.||.|:.:.|.. ||:          |:|:.:|
Human   414 FRCAEGFMLRGADIVRCDNLGQWTAPAPVCQALQCQD-LPVPNEARVNCSHPFGAFRY------- 470

  Fly   722 GSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMYGRTLI 786
            .|...|:|::...|.|.....||.:..|:...|:|:.|.| .|.|:..       |..|   |.:
Human   471 QSVCSFTCNEGLLLVGASVLQCLATGNWNSVPPECQAIPC-TPLLSPQ-------NGTM---TCV 524

  Fly   787 RTSESSQNTAQTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECG---APEGIN 848
            :...||     :||  :..::.|:.||.:.|.....||.||:|:.:.|.|..::|.   |||
Human   525 QPLGSS-----SYK--STCQFICDEGYSLSGPERLDCTRSGRWTDSPPMCEAIKCPELFAPE--- 579

  Fly   849 NGKVVLATNATYY--GAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVV-CDTPNINENL 910
            .|.:..:.....:  |:...:.|:..|||.|.:...||..|.||...|.|..:. ..||.:....
Human   580 QGSLDCSDTRGEFNVGSTCHFSCDNGFKLEGPNNVECTTSGRWSATPPTCKGIASLPTPGVQCPA 644

  Fly   911 IVEAG---------PRAVGSVAT--FKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLA 964
            :...|         |...|...|  |.|..|..::|:.|..|:.:|:||..:|.||.|.|..
Human   645 LTTPGQGTMYCRHHPGTFGFNTTCYFGCNAGFTLIGDSTLSCRPSGQWTAVTPACRAVKCSE--- 706

  Fly   965 IENGRVIVVNDSTL-----YGGSAEYHCIPNYNRIGQYLRKCTEDGAWSGKQPRCELATAEGQET 1024
            :...:.|.:|.|.|     ||....:||:......|.....|.|:|.||...|.|:......||.
Human   707 LHVNKPIAMNCSNLWGNFSYGSICSFHCLEGQLLNGSAQTACQENGHWSTTVPTCQAGPLTIQEA 771

  Fly  1025 SELGTGVGIGATVIVALLVIFG--LIFLYRNKAR 1056
            ...     .|..|...:.:|.|  |:.|.|.:.|
Human   772 LTY-----FGGAVASTIGLIMGGTLLALLRKRFR 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870	3/16 (19%)
		CLECT	281..403	CDD:153057	32/135 (24%)
		CCP	408..462	CDD:153056	8/53 (15%)
		CCP	466..520	CDD:153056	14/56 (25%)
		CCP	525..579	CDD:153056	16/57 (28%)
		CCP	583..639	CDD:153056	15/57 (26%)
		PHA02927	637..897	CDD:222943	75/282 (27%)
		CCP	643..697	CDD:153056	17/61 (28%)
		CCP	701..757	CDD:153056	15/65 (23%)
		Sushi	<799..836	CDD:278512	12/36 (33%)
		Sushi	841..896	CDD:278512	17/59 (29%)
		CCP	901..955	CDD:153056	16/64 (25%)
		CCP	959..1015	CDD:153056	16/60 (27%)
SELP	NP_002996.2	CLECT_selectins_like	42..160	CDD:153062	32/134 (24%)
		EGF_CA	<168..195	CDD:238011	7/48 (15%)
		CCP	200..257	CDD:153056	14/56 (25%)
		CCP	262..320	CDD:153056	16/57 (28%)
		CCP	324..382	CDD:153056	15/57 (26%)
		CCP	386..444	CDD:153056	17/61 (28%)
		CCP	448..506	CDD:153056	15/65 (23%)
		PHA02927	505..761	CDD:222943	76/279 (27%)
		CCP	510..568	CDD:153056	20/75 (27%)
		CCP	572..630	CDD:153056	17/60 (28%)
		CCP	642..700	CDD:153056	14/57 (25%)
		CCP	704..762	CDD:153056	16/60 (27%)
		Endocytosis signal. /evidence=ECO:0000305	818..821
		Interaction with SNX17	821..830
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	239	1.000	Inparanoid score	I3356
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002067
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.050